gene

MMP7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MMP7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

36Outgoing

7Incoming

Summary

MMP7 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, implicated in. Associated with Als, Cancer, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MMP7
Full Name	Matrix Metalloproteinase 7
Aliases	Page for MMP7
Function	MMP7 (Matrix Metallopeptidase 7), also known as matrilysin, is a unique member of the MMP family characterized by its small size and specific substrate profile.
Primary Expression	Paneth cells and mucous membranes, where it generates antimicrobial peptides from precursors, providing innate immune protection
Pathways	oxidative stress response
Ensembl ID	ENSG00000137673
GeneCards	MMP7
Human Protein Atlas	MMP7
Extracellular Matrix Remodeling	MMP7 degrades elastin, casein, gelatin, and non-helical collagen. Unlike other MMPs, it does not degrade triple-helical collagen.
Antimicrobial Defense	MMP7 is expressed in Paneth cells and mucous membranes, where it generates antimicrobial peptides from precursors, providing innate immune protection.
Wound Healing	The protease promotes re-epithelialization and keratinocyte migration during tissue repair.
Associated Diseases	ALS, Fibrosis
Interactions	CD4, Proteins, Ras, App, COL6A1
KG Connections	43 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MMP7["<b>MMP7</b>"]
    Als{"Als"}
    MMP7 -->|"biomarker for"| Als
    Ms{"Ms"}
    MMP7 -->|"biomarker for"| Ms
    Cancer{"Cancer"}
    MMP7 -->|"biomarker for"| Cancer
    Tumor{"Tumor"}
    MMP7 -->|"biomarker for"| Tumor
    MMP1["MMP1"]
    MMP7 -->|"associated with"| MMP1
    CDC25B["CDC25B"]
    MMP7 -->|"associated with"| CDC25B
    CD8["CD8"]
    MMP7 -->|"biomarker for"| CD8
    CANCER["CANCER"]
    MMP7 -->|"biomarker for"| CANCER
    GBM["GBM"]
    MMP7 -->|"biomarker for"| GBM
    CDK4["CDK4"]
    MMP7 -->|"associated with"| CDK4
    UHRF1["UHRF1"]
    MMP7 -->|"associated with"| UHRF1
    neurodegeneration["neurodegeneration"]
    MMP7 -->|"implicated in"| neurodegeneration
    CD4["CD4"]
    CD4 -->|"biomarker for"| MMP7
    style MMP7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (36)

Target	Relation	Type	Str
Kidney Disease	biomarker_for	disease	0.80
Fibrosis	promotes	process	0.80
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Tumor	biomarker_for	disease	0.65
Als	therapeutic_target	disease	0.65
Fibrosis	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
MMP1	associated_with	gene	0.60
CDC25B	associated_with	gene	0.60
CD8	biomarker_for	gene	0.60
GBM	biomarker_for	gene	0.60
CDK4	associated_with	gene	0.60
UHRF1	associated_with	gene	0.60
CD4	activates	gene	0.60
CANCER	biomarker_for	gene	0.60
RNA	therapeutic_target	gene	0.60
Epithelial	therapeutic_target	cell_type	0.60
T Cell	therapeutic_target	cell_type	0.60
KRTAPS	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
AND	associated_with	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
Ras	activates	protein	0.60
App	activates	protein	0.60
oxidative stress response	participates_in	pathway	0.60
ALS	associated_with	disease	0.60
T cells	expressed_in	cell_type	0.60
T Cell	expressed_in	cell_type	0.55
FIBROSIS	activates	disease	0.50
Proteins	activates	protein	0.50

Incoming (7)

Source	Relation	Type	Str
Metformin	downregulates	drug	0.85
CD4	biomarker_for	gene	0.60
COL6A1	activates	gene	0.60
KRTAPS	associated_with	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
RNA	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MMP7

Understanding Entity Pages

Summary

Wiki Pages (5)

MMP7 - Matrix Metallopeptidase 7

MMP12 - Matrix Metallopeptidase 12

Arrowhead Pharmaceuticals