protein

CPLX2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CPLX2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

Summary

Complexin 2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	CPLX2PROTEIN
Full Name	Complexin-2
Protein Family	Complexin family (CPLX1-4)
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	14.5 kDa
UniProt ID	O75178
GeneCards	CPLX2PROTEIN
Human Protein Atlas	CPLX2PROTEIN
N-terminal domain	Binds to assembled SNARE complexes
Central α-helical domain	The spine that interacts with SNARE bundle
C-terminal domain	Membrane attachment via hydrophobic interactions
Associated Diseases	Alzheimer, neurodegeneration
Interactions	BDNF, DNM1L, ICAM1, PINK1, TFAM, TNF
KG Connections	15 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CPLX2PROTEIN — AlphaFold O75178 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Complexin-2 Protein

protein · 615 words

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Pathway Diagram

graph TD
    CPLX2PROTEIN["CPLX2PROTEIN"]
    microglia["microglia"]
    CPLX2PROTEIN -->|"binds"| microglia
    TREM2["TREM2"]
    TREM2 -->|"associated_with"| CPLX2PROTEIN
    neurodegeneration["neurodegeneration"]
    CPLX2PROTEIN -->|"implicated_in"| neurodegeneration
    style CPLX2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
microglia	binds	cell_type	0.80

Incoming (1)

Source	Relation	Type	Str
TREM2	associated_with	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CPLX2PROTEIN in their description or question text

No additional research found