gene

ICAM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ICAM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

416Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ICAM1 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with ALS, Als, Alzheimer. Connected to 220 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ICAM1
Full Name	Intercellular Adhesion Molecule 1
Chromosome	19p13.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	23 aa
UniProt ID	P05362
NCBI Gene ID	3383
Ensembl ID	ENSG00000090339
GeneCards	ICAM1
Human Protein Atlas	ICAM1
Official Name	Intercellular Adhesion Molecule 1
NCBI Reference	NM_000201
Integrin	Alternative Name
ITGAL/CD11a	LFA-1
ITGAM/CD11b	Mac-1
Associated Diseases	ALS, Alzheimer, Chronic Obstructive Pulmonary Disease, Fibrosis, Ms
Interactions	SPP1, TNF, TNFRSF1A, IL6, TLR4, MYD88
KG Connections	416 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ICAM1 — AlphaFold P05362 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ICAM1["ICAM1"] -->|"activates"| Inflammation["Inflammation"]
    ICAM1["ICAM1"] -->|"activates"| Anxiety["Anxiety"]
    ICAM1["ICAM1"] -->|"activates"| Als["Als"]
    ICAM1["ICAM1"] -->|"activates"| Tumor["Tumor"]
    ICAM1["ICAM1"] -->|"activates"| Depression["Depression"]
    ICAM1["ICAM1"] -->|"activates"| Ms["Ms"]
    CRY1["CRY1"] -->|"activates"| ICAM1["ICAM1"]
    BMAL1["BMAL1"] -->|"activates"| ICAM1["ICAM1"]
    ARNT["ARNT"] -->|"activates"| ICAM1["ICAM1"]
    TNF["TNF"] -->|"activates"| ICAM1["ICAM1"]
    style ICAM1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (312)

Target	Relation	Type	Str
Monocyte Adherence	promotes	process	0.85
podocyte detachment	mediates	phenotype	0.85
Chronic Obstructive Pulmonary Disease	associated_with	disease	0.80
monocyte migration	mediates	process	0.80
neuroinflammation	involved_in	process	0.80
oxidative stress response	participates_in	pathway	0.80
Multiple Sclerosis	implicated_in	disease	0.80
Inflammation	activates	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Atherosclerosis	therapeutic_target	disease	0.75
neuroinflammation	biomarker_for	process	0.72
CYTOKINES	therapeutic_target	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
INFLAMMATION	activates	gene	0.70
Anxiety	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Depression	activates	disease	0.65
Ms	activates	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Anxiety	contributes_to	disease	0.65
Depression	contributes_to	disease	0.65
Inflammation	contributes_to	disease	0.65
Tumor	contributes_to	disease	0.65
Stroke	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Stroke	activates	disease	0.65
Ischemia	activates	disease	0.65
Fibrosis	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Diabetes	activates	disease	0.65
ALS	activates	disease	0.65
Ulcerative Colitis	therapeutic_target	disease	0.65
Heart Failure	activates	disease	0.65
Cardiac	expressed_in	disease	0.65
Coronary Artery Disease	therapeutic_target	disease	0.65
Sepsis	therapeutic_target	disease	0.65

Incoming (104)

Source	Relation	Type	Str
AΒ1-42	alters	compound	0.80
SNCA	alters	gene	0.80
CRY1	activates	gene	0.60
BMAL1	activates	gene	0.60
ARNT	activates	gene	0.60
TNF	activates	gene	0.60
TNFRSF1A	activates	gene	0.60
OCLN	activates	gene	0.60
CXCL10	associated_with	gene	0.60
TNF	associated_with	gene	0.60
BAX	inhibits	gene	0.60
CXCL2	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
MMP9	associated_with	gene	0.60
VCAM1	associated_with	gene	0.60
RAGE	therapeutic_target	gene	0.60
SERPINE1	inhibits	gene	0.60
NOS2	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
KDR	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
ARNT	contributes_to	gene	0.60
BMAL1	contributes_to	gene	0.60
CRY1	contributes_to	gene	0.60
CXCL8	inhibits	gene	0.60
ANXA2	activates	gene	0.60
MAPK3	therapeutic_target	gene	0.60
IL1B	activates	gene	0.60
CD14	activates	gene	0.60
TREM2	activates	gene	0.60
C5AR1	associated_with	gene	0.60
SERPINA3	therapeutic_target	gene	0.60
IL6	associated_with	gene	0.60
TNF	therapeutic_target	gene	0.60
HSP70	associated_with	gene	0.60
IBA1	activates	entity	0.60
CXCL8	associated_with	gene	0.60
MMP3	associated_with	gene	0.60
TDP-43	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
PPAR	associated_with	gene	0.60
AKT	expressed_in	gene	0.60
APOE	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60
CCL20	associated_with	gene	0.60
FGF2	associated_with	gene	0.60
IL13	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ICAM1

Understanding Entity Pages

Summary

Wiki Pages (19)

ICAM1 - Intercellular Adhesion Molecule 1

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

Intercellular Adhesion Molecule-5 Protein

KIF3B — Kinesin Family Member 3B

VCAM1 - Vascular Cell Adhesion Molecule 1

PECAM1 - Platelet Endothelial Cell Adhesion Molecule 1

TUBB1 — Tubulin Beta 1

KDR Gene

PECAM1 Protein

VCAM1 Protein

ICAM1 Protein

IL1A — Interleukin 1 Alpha

gclc

NOS2 - Nitric Oxide Synthase 2

CPLX2 — Complexin 2

ICAM5 (Intercellular Adhesion Molecule 5)

JAM2 - Junctional Adhesion Molecule 2