Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DARS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DARS2 |
| Full Name | Mitochondrial Aspartyl-tRNA Synthetase |
| Chromosome | 12q24.1 |
| Protein Type | Synthetase |
| Function | is a critical mitochondrial aminoacyl-tRNA synthetase that plays an essential role in mitochondrial protein synthesis. |
| Subcellular Localization | mitochondria: |
| Molecular Weight | 73.8 kDa |
| Amino Acids | 50 aa |
| Pathways | Invasion, Metastasis |
| UniProt ID | Q7Z4W5 |
| NCBI Gene ID | 55157 |
| Ensembl ID | ENSG00000117682 |
| OMIM | 611105 |
| GeneCards | DARS2 |
| Human Protein Atlas | DARS2 |
| Associated Diseases | neurodegeneration |
| Interactions | MYC, PINK1, CDK4, ERK |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
DARS2(["DARS2"])
Tumor["Tumor"]
Carcinoma["Carcinoma"]
MYC(["MYC"])
Metastasis["Metastasis"]
Invasion["Invasion"]
ERK(["ERK"])
neurodegeneration["neurodegeneration"]
DARS2 -->|"activates"| Tumor
DARS2 -->|"activates"| Carcinoma
DARS2 -->|"activates"| MYC
DARS2 -->|"activates"| Metastasis
DARS2 -->|"activates"| Invasion
ERK -->|"activates"| DARS2
DARS2 -->|"implicated in"| neurodegeneration
style DARS2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Tumor | activates | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| MYC | activates | gene | 0.60 |
| cancer | regulates | disease | 0.60 |
| PINK1 | regulates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| Metastasis | activates | pathway | 0.60 |
| Invasion | activates | pathway | 0.60 |
| senescence | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||