protein

DARS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DARS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

9Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for DARS2 Protein

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🔬 Protein Info

Gene Symbol	DARS2
Chromosome	12q24.1
Protein Type	Synthetase
Function	is a critical mitochondrial aminoacyl-tRNA synthetase that plays an essential role in mitochondrial protein synthesis.
Molecular Weight	73.8 kDa
Amino Acids	50 aa
Pathways	Invasion, Metastasis
Ensembl ID	ENSG00000117682
GeneCards	DARS2
Human Protein Atlas	DARS2
Associated Diseases	neurodegeneration
Interactions	CDK4, ERK, MYC, PINK1
KG Connections	11 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DARS2 Protein

protein · 1185 words

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DARS2 Gene

gene · 757 words

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Pathway Diagram

flowchart TD
    DARS2(["DARS2"])
    Tumor["Tumor"]
    Carcinoma["Carcinoma"]
    MYC(["MYC"])
    Metastasis["Metastasis"]
    Invasion["Invasion"]
    ERK(["ERK"])
    neurodegeneration["neurodegeneration"]

    DARS2 -->|"activates"| Tumor
    DARS2 -->|"activates"| Carcinoma
    DARS2 -->|"activates"| MYC
    DARS2 -->|"activates"| Metastasis
    DARS2 -->|"activates"| Invasion
    ERK -->|"activates"| DARS2
    DARS2 -->|"implicated in"| neurodegeneration

    style DARS2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (9)

Target	Relation	Type	Str
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
PINK1	regulates	gene	0.60
PINK1	activates	gene	0.60
Metastasis	activates	pathway	0.60
Invasion	activates	pathway	0.60
MYC	activates	gene	0.60
senescence	participates_in	pathway	0.60
cancer	regulates	disease	0.60

Incoming (2)

Source	Relation	Type	Str
CDK4	activates	gene	0.60
ERK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DARS2 in their description or question text

No additional research found