gene

DLX5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLX5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

5Outgoing

8Incoming

0Experiments

0Debates

Summary

DLX5 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, implicated in, activates. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DLX5
Chromosome	7q22.1
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	32 kDa
Amino Acids	325 aa
Exons	3
GeneCards	DLX5
Human Protein Atlas	DLX5
Homeobox domain	60 amino acid DNA-binding motif
Conserved gene cluster	DLX5-DLX6 bidirectional promoter
Enhancer elements	Multiple CNS-specific enhancers
Epigenetic regulation	Bivalent histone marks in embryonic stem cells
Homeodomain	Helix-turn-helix DNA-binding motif (positions 136-195)
C-terminal regulatory domain	Interactions with co-factors
Associated Diseases	neurodegeneration
Interactions	AND, GENES
KG Connections	13 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DLX5 Gene

gene · 729 words

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DLX5 Protein

protein · 1118 words

→

Pathway Diagram

graph TD
    DLX5["DLX5"]
    Akt(["Akt"])
    DLX5 -->|"therapeutic target"| Akt
    Pi3K(["Pi3K"])
    DLX5 -->|"therapeutic target"| Pi3K
    AKT["AKT"]
    DLX5 -->|"therapeutic target"| AKT
    CASP3["CASP3"]
    DLX5 -->|"therapeutic target"| CASP3
    HMGCR["HMGCR"]
    DLX5 -->|"therapeutic target"| HMGCR
    neurodegeneration["neurodegeneration"]
    DLX5 -->|"implicated in"| neurodegeneration
    CASP3 -->|"therapeutic target"| DLX5
    PI3K["PI3K"]
    PI3K -->|"therapeutic target"| DLX5
    HMGCR -->|"therapeutic target"| DLX5
    GENES["GENES"]
    GENES -->|"activates"| DLX5
    PTGS2["PTGS2"]
    PTGS2 -->|"therapeutic target"| DLX5
    AKT -->|"therapeutic target"| DLX5
    style DLX5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
Akt	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
AKT	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60
HMGCR	therapeutic_target	gene	0.60

Incoming (8)

Source	Relation	Type	Str
PPAR	therapeutic_target	gene	0.60
AND	activates	gene	0.60
CASP3	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
HMGCR	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
GENES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DLX5 in their description or question text

No additional research found