gene

HMGCR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HMGCR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

815Connections

2Hypotheses

6Analyses

50Outgoing

50Incoming

0Experiments

17Debates

Summary

HMGCR is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, inhibits. Associated with AD, ALS, AMI. Connected to 244 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HMGCR
Full Name	3-Hydroxy-3-Methylglutaryl-CoA Reductase
Chromosome	5
Function	HMGCR plays a critical role in cholesterol metabolism, which is intimately connected to Alzheimer's disease pathogenesis through multiple mechanisms:
Pathways	Amyloid, Autophagy, Cholesterol, Cholesterol Metabolism, Lipid Metabolism
UniProt ID	[P04035](https://www.uniprot.org/uniprotkb/P04035/entry)
Ensembl ID	ENSG00000013113
GeneCards	HMGCR
Human Protein Atlas	HMGCR
Associated Diseases	AD, Als, Alzheimer, Alzheimer disease, Alzheimer's disease
Known Drugs/Compounds	25-Hydroxycholesterol, SIMVASTATIN, statins
Interactions	A2M, ABCA1, ACSL4, AGING, Akt, AKT
SciDEX Hypotheses	Membrane Lipid Composition Therapeutic Modulation Membrane Lipid Raft Reorganization Therapy
KG Connections	814 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HMGCR — 3-Hydroxy-3-Methylglutaryl-CoA Reductase

gene · 612 words

→

HMGCR Protein — HMG-CoA Reductase

protein · 559 words

→

Pathway Diagram

flowchart TD
    HMGCR["HMGCR
HMG-CoA Reductase
Rate-limiting enzyme"]
    
    Cholesterol["Cholesterol
Biosynthesis
Pathway"]
    Statins["Statin Therapy
HMGCR Inhibition"]
    
    APP["APP
Amyloid Precursor
Protein"]
    PSEN1["PSEN1
Presenilin-1
gamma-secretase component"]
    MAPT["MAPT
Tau Protein
Microtubule binding"]
    
    Inflammation["Neuroinflammation
IL1B-mediated
responses"]
    IL1B["IL1B
Interleukin-1beta
Pro-inflammatory"]
    
    Apoptosis["Apoptosis
Pathway
Cell death"]
    PARP1["PARP1
DNA repair
enzyme"]
    DAPK1["DAPK1
Death-associated
protein kinase"]
    
    Alzheimer["Alzheimer's
Disease"]
    ALS["ALS
Motor neuron
degeneration"]
    Dementia["Dementia
Cognitive decline"]
    Depression["Depression
Mood disorder"]
    
    HMGCR -->|"regulates"| Cholesterol
    HMGCR -->|"interacts_with"| APP
    HMGCR -->|"interacts_with"| PSEN1
    HMGCR -->|"interacts_with"| MAPT
    HMGCR -->|"inhibits"| Inflammation
    HMGCR -->|"interacts_with"| IL1B
    HMGCR -->|"modulates"| Apoptosis
    HMGCR -->|"interacts_with"| PARP1
    HMGCR -->|"interacts_with"| DAPK1
    
    Statins -->|"inhibits"| HMGCR
    
    APP -->|"contributes_to"| Alzheimer
    PSEN1 -->|"contributes_to"| Alzheimer
    MAPT -->|"contributes_to"| Alzheimer
    
    HMGCR -->|"associated_with"| Alzheimer
    HMGCR -->|"associated_with"| ALS
    HMGCR -->|"therapeutic_target"| Dementia
    HMGCR -->|"associated_with"| Depression
    
    Apoptosis -->|"leads_to"| ALS
    Inflammation -->|"contributes_to"| Alzheimer
    
    style HMGCR fill:#006494
    style Statins fill:#1b5e20
    style Cholesterol fill:#4a1a6b
    style Inflammation fill:#ef5350
    style Apoptosis fill:#ef5350
    style Alzheimer fill:#5d4400
    style ALS fill:#5d4400
    style Dementia fill:#5d4400
    style Depression fill:#5d4400
    style APP fill:#4a1a6b
    style PSEN1 fill:#4a1a6b
    style MAPT fill:#4a1a6b

Outgoing (486)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:HMGCR	data_in	dataset_row	0.00
HMGCR	encodes	protein	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
cholesterol_synthesis	activates	pathway	0.90
cholesterol_synthesis	regulates	pathway	0.90
cholesterol synthesis	upstream_of	process	0.90
multiple sclerosis	associated_with	disease	0.80
Amyloid-β	regulates	protein	0.80
excitotoxicity	inhibits	process	0.80
endothelial nitric oxide synthase	stimulates	protein	0.80
apolipoprotein E	regulates	protein	0.80
cerebral ischemic stroke	implicated_in	disease	0.80
matrix metalloproteinases	modulates	protein	0.80
pro-inflammatory/anti-inflammatory cytokines	balances	process	0.80
neurons	inhibits	cell_type	0.80
cerebral blood perfusion	increases	process	0.80
reactive oxygen and nitrogen species	inhibits	process	0.80
unfolded protein response	participates_in	pathway	0.80
lipid metabolism	participates_in	pathway	0.80
neural stem cells	regulates	cell_type	0.70
neurons	activates	cell_type	0.70
membrane lipid composition	modulates	mechanism	0.70
AKT	therapeutic_target	gene	0.70
oxidative stress response	participates_in	pathway	0.70
cholesterol_biosynthesis	regulates	biological_process	0.70
Cholesterol	activates	pathway	0.70
Carcinoma	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	regulates	disease	0.65
Inflammation	activates	disease	0.65
Dementia	interacts_with	disease	0.65
Migraine	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Autoimmune	regulates	disease	0.65
Cirrhosis	activates	disease	0.65
Ovarian Cancer	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Cardiovascular	inhibits	disease	0.65
Ms	activates	disease	0.65
Pyroptosis	activates	disease	0.65
Cancer	activates	disease	0.65
Ferroptosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65

Incoming (329)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:HMGCR	data_in	dataset_row	0.00
HMGCR	encodes	gene	0.00
ds-83b31ef18d49	data_in	dataset	1.00
TDP-43	binds	protein	1.00
TNF	upregulates	protein	0.90
h-a87702b6	targets_gene	hypothesis	0.90
statins	inhibits	compound	0.90
25-Hydroxycholesterol	modulates	compound	0.85
BECN1-HSPA5 complex	promotes	protein	0.83
statins	activates	compound	0.80
PI3K	therapeutic_target	gene	0.70
TNF	interacts_with	gene	0.70
IL6	interacts_with	gene	0.70
IL1B	interacts_with	gene	0.70
SREBP2	regulates	protein	0.70
SREBF2	activates	gene	0.70
CHOLESTEROL	destabilizes	phenotype	0.65
APOE4	activates	gene	0.65
NF-KB SIGNALING	activates	pathway	0.65
NF-KB SIGNALING	regulates	pathway	0.65
BRCA2	modifies	gene	0.65
LIPID PEROXIDATION	treats	phenotype	0.65
ACC	expressed_in	gene	0.60
MOTOR NEURONS	inhibits	gene	0.60
MIRNAS	inhibits	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
ATP	inhibits	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
HIF	activates	gene	0.60
DNA	activates	gene	0.60
GFP	activates	gene	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
ASTROCYTES	synergizes_with	cell_type	0.60
ASTROCYTE	targets	cell_type	0.60
CHOLESTEROL	targets	phenotype	0.60
AMPK	activates	gene	0.60
DMSO	activates	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
MITOCHONDRIA	expressed_in	gene	0.60
PYROPTOSIS	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
MICRORNAS	regulates	gene	0.60
ANXIETY	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CYP2E1	associated_with	gene	0.60
PER	interacts_with	gene	0.60
SREBP-2	regulates	protein	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Membrane Lipid Composition Therapeutic Modulation	0.455	neurodegeneration	How do host cell factors influence the c
Membrane Lipid Raft Reorganization Therapy	0.000	-	What determines the selectivity and effi

Mentioning Analyses (6)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (17)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning HMGCR in their description or question text

No additional research found

HMGCR

Understanding Entity Pages

Summary

Wiki Pages (2)

HMGCR — 3-Hydroxy-3-Methylglutaryl-CoA Reductase

HMGCR Protein — HMG-CoA Reductase

Pathway Diagram

Outgoing (486)

Incoming (329)

Targeting Hypotheses (2)

Mentioning Analyses (6)

Is APOE4's reduced lipid binding pathogenic or a compensatory evolutionary adapt

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

How do host cell factors influence the conformation and propagation properties o

CRISPR-based therapeutic approaches for neurodegenerative diseases

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Lipid raft composition changes in synaptic neurodegeneration

Experiments (0)

Related Papers (0)

Debates (17)

Second debate: Microglial TREM2-SYK Pathway Enhancement

Extended debate: CYP46A1 Overexpression Gene Therapy

Debate: LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferroptotic Primin

Debate: ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes via PUFA-PE P

Debate: LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vulnerability i

Debate: ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligodendrocytes

Hypothesis debate: Membrane Cholesterol Gradient Modulators

Should '40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Sele

Should 'ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matt

Hypothesis debate: Selective Acid Sphingomyelinase Modulation Therapy

Related Research