HMGCR

Understanding Entity Pages

This page aggregates everything SciDEX knows about HMGCR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

HMGCR is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, inhibits. Associated with AD, ALS, AMI. Connected to 244 entities in the SciDEX knowledge graph.

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flowchart TD
    HMGCR["HMGCR<br/>HMG-CoA Reductase<br/>Rate-limiting enzyme"]
    
    Cholesterol["Cholesterol<br/>Biosynthesis<br/>Pathway"]
    Statins["Statin Therapy<br/>HMGCR Inhibition"]
    
    APP["APP<br/>Amyloid Precursor<br/>Protein"]
    PSEN1["PSEN1<br/>Presenilin-1<br/>gamma-secretase component"]
    MAPT["MAPT<br/>Tau Protein<br/>Microtubule binding"]
    
    Inflammation["Neuroinflammation<br/>IL1B-mediated<br/>responses"]
    IL1B["IL1B<br/>Interleukin-1beta<br/>Pro-inflammatory"]
    
    Apoptosis["Apoptosis<br/>Pathway<br/>Cell death"]
    PARP1["PARP1<br/>DNA repair<br/>enzyme"]
    DAPK1["DAPK1<br/>Death-associated<br/>protein kinase"]
    
    Alzheimer["Alzheimer's<br/>Disease"]
    ALS["ALS<br/>Motor neuron<br/>degeneration"]
    Dementia["Dementia<br/>Cognitive decline"]
    Depression["Depression<br/>Mood disorder"]
    
    HMGCR --|"regulates"|--> Cholesterol
    HMGCR --|"interacts_with"|--> APP
    HMGCR --|"interacts_with"|--> PSEN1
    HMGCR --|"interacts_with"|--> MAPT
    HMGCR --|"inhibits"|--> Inflammation
    HMGCR --|"interacts_with"|--> IL1B
    HMGCR --|"modulates"|--> Apoptosis
    HMGCR --|"interacts_with"|--> PARP1
    HMGCR --|"interacts_with"|--> DAPK1
    
    Statins --|"inhibits"|--> HMGCR
    
    APP --|"contributes_to"|--> Alzheimer
    PSEN1 --|"contributes_to"|--> Alzheimer
    MAPT --|"contributes_to"|--> Alzheimer
    
    HMGCR --|"associated_with"|--> Alzheimer
    HMGCR --|"associated_with"|--> ALS
    HMGCR --|"therapeutic_target"|--> Dementia
    HMGCR --|"associated_with"|--> Depression
    
    Apoptosis --|"leads_to"|--> ALS
    Inflammation --|"contributes_to"|--> Alzheimer
    
    style HMGCR fill:#006494
    style Statins fill:#1b5e20
    style Cholesterol fill:#4a1a6b
    style Inflammation fill:#ef5350
    style Apoptosis fill:#ef5350
    style Alzheimer fill:#5d4400
    style ALS fill:#5d4400
    style Dementia fill:#5d4400
    style Depression fill:#5d4400
    style APP fill:#4a1a6b
    style PSEN1 fill:#4a1a6b
    style MAPT fill:#4a1a6b