protein

PPAR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPAR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1015Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Page for PPAR (Peroxisome Proliferator-Activated Receptor)

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🔬 Protein Info

Gene Symbol	PPAR
Full Name	PPAR (Peroxisome Proliferator-Activated Receptor)
Aliases	Peroxisome Proliferator-Activated Receptor
Protein Type	Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neurons, astrocytes, microglia, and oligodendrocytes, where they modulate critical processes including neuroinflammation, mit
Pathways	Apoptosis, Autophagy, Differentiation, Epigenetic, Lipid Metabolism
UniProt ID	Search UniProt
GeneCards	PPAR
Human Protein Atlas	PPAR
Associated Diseases	AD, ALS, AMI, ARDS, ARM
Known Drugs/Compounds	SDHHQ, kaempferol
Interactions	TNF, OCLN, MLCK, PINK1, NLRP3, LRRK2
KG Connections	1015 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PPAR — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    PPAR["PPAR"] -->|"activates"| Obesity["Obesity"]
    PPAR["PPAR"] -->|"activates"| Diabetes["Diabetes"]
    PPAR["PPAR"] -->|"protects against"| Neurodegeneration["Neurodegeneration"]
    PPAR["PPAR"] -->|"activates"| Inflammation["Inflammation"]
    PPAR["PPAR"] -->|"associated with"| ALS["ALS"]
    PPAR["PPAR"] -->|"associated with"| Inflammation["Inflammation"]
    PPAR["PPAR"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    PPAR["PPAR"] -->|"activates"| ALS["ALS"]
    PPAR["PPAR"] -->|"activates"| Tumor["Tumor"]
    PPAR["PPAR"] -->|"activates"| Parkinson["Parkinson"]
    PPAR["PPAR"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    PPAR["PPAR"] -->|"activates"| TNF["TNF"]
    style PPAR fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Obesity fill:#ef5350,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neurodegeneration fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style TNF fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (706)

Target	Relation	Type	Str
Diabetes	activates	disease	1.00
NRF2	activates	gene	0.90
AMPK	activates	gene	0.90
fatty acid metabolism	regulates	process	0.85
Obesity	activates	disease	0.85
Inflammation	activates	disease	0.85
Tumor	activates	disease	0.85
Als	regulates	disease	0.85
Als	therapeutic_target	disease	0.85
Cancer	activates	disease	0.85
Fatty Liver	activates	disease	0.85
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
SIRT1	activates	gene	0.80
Lipid Metabolism	activates	pathway	0.80
OXIDATIVE STRESS	activates	gene	0.80
CANCER	activates	gene	0.80
GENES	activates	gene	0.80
Oxidative Stress	activates	pathway	0.80
Parkinson	activates	disease	0.75
Als	activates	disease	0.75
Tumor	associated_with	disease	0.75
Diabetes	therapeutic_target	disease	0.75
PINK1	activates	gene	0.70
LRRK2	activates	gene	0.70
AKT	activates	gene	0.70
PI3K	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
PPAR-Γ	activates	gene	0.70
DJ-1	activates	gene	0.70
PARKINSON	activates	gene	0.70
Differentiation	activates	pathway	0.70
NF-ΚB	activates	gene	0.70
Wnt	activates	pathway	0.70
Cell Cycle	activates	pathway	0.70
Nf-Κb	activates	pathway	0.70
GENES	therapeutic_target	gene	0.70
unfolded protein response	participates_in	pathway	0.70
lipid metabolism	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
neural stem cells	expressed_in	cell_type	0.70
Neurodegeneration	protects_against	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Stroke	regulates	disease	0.65
Ms	regulates	disease	0.65
Ischemia	regulates	disease	0.65

Incoming (309)

Source	Relation	Type	Str
Huanglian-Hongqu herb pair	regulates	drug	0.90
SDHHQ	modulates	drug	0.85
kaempferol	activates	compound	0.80
PPAR-Γ	activates	gene	0.70
CLDN1	activates	gene	0.60
AQP4	activates	gene	0.60
PRKN	activates	gene	0.60
SNCA	activates	gene	0.60
TNF	activates	gene	0.60
OCLN	activates	gene	0.60
MLCK	inhibits	gene	0.60
NRF2	activates	gene	0.60
SLC7A11	activates	gene	0.60
OVERVIEW	protects_against	gene	0.60
GPX4	inhibits	gene	0.60
BAX	inhibits	gene	0.60
PI3K	therapeutic_target	gene	0.60
HMGCR	therapeutic_target	gene	0.60
MLCK	phosphorylates	entity	0.60
NLRP3	activates	entity	0.60
AKT	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
PPARG	activates	gene	0.60
ERK1	inhibits	gene	0.60
PPARA	activates	gene	0.60
EGFR	activates	gene	0.60
MAPK1	activates	gene	0.60
SLC2A1	activates	gene	0.60
IGF1	activates	gene	0.60
TFAM	activates	gene	0.60
NRF1	activates	gene	0.60
PARKIN	activates	gene	0.60
SIRT1	activates	gene	0.60
LRRK2	activates	gene	0.60
PINK1	activates	gene	0.60
BAX	therapeutic_target	gene	0.60
BCL2	therapeutic_target	gene	0.60
CASPASE3	therapeutic_target	gene	0.60
P38	contributes_to	gene	0.60
AKT	contributes_to	gene	0.60
TAU	contributes_to	gene	0.60
NRF2	regulates	gene	0.60
GPX4/SLC7A11	therapeutic_target	gene	0.60
ACSL4	therapeutic_target	gene	0.60
SCD1	inhibits	gene	0.60
MLKL	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60
FASN	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.619

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PPAR

Understanding Entity Pages

Summary

Wiki Pages (21)

PPAR (Peroxisome Proliferator-Activated Receptor)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Therapeutics

Microglial Cells — Cell Type Hierarchy

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

APOC4 — Apolipoprotein C-IV

omega-3-fatty-acids-neurodegeneration

COX20 Gene - Cytochrome c Oxidase Assembly Factor

Peroxisome Pathway in Neurodegeneration

metabolic-dysfunction-neurodegeneration

Lipid Metabolism Dysfunction Comparison — AD/PD/ALS/FTD/HD

Peroxisomal Dysfunction

Transcriptional Regulation in Neurodegeneration

Lipid Metabolism Dysregulation in Neurodegeneration

Mitochondria in Neurodegeneration

ad-prevention-vs-treatment

Neuroinflammation Microglia

FBXO7 — F-Box Protein 7

ALS Pipeline

Microglial Phagocytosis in Neurodegeneration