pathway

Pi3K

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Pi3K: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7192Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Pi3K is a biological pathway involved in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with Aging, Als, Alzheimer. Connected to 1075 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Pi3K
Key Genes/Proteins	AKT, ACTB, P2RY12, APOA1, ULK1, ATG5
Related Diseases	Glioblastoma Multiforme, Atherosclerosis
Linked Hypotheses	3 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Pi3K["Pi3K"] -->|"interacts"| Cholesterol["Cholesterol"]
    Pi3K["Pi3K"] -->|"interacts"| Mtor["Mtor"]
    Pi3K["Pi3K"] -->|"interacts"| Wnt["Wnt"]
    Pi3K["Pi3K"] -->|"interacts"| Mapk["Mapk"]
    Pi3K["Pi3K"] -->|"interacts"| Glycolysis["Glycolysis"]
    Pi3K["Pi3K"] -->|"interacts"| Tgf__["Tgf-Beta"]
    ACTB["ACTB"] -.->|"inhibits"| Pi3K["Pi3K"]
    P2RY12["P2RY12"] -.->|"inhibits"| Pi3K["Pi3K"]
    APOA1["APOA1"] -.->|"inhibits"| Pi3K["Pi3K"]
    ULK1["ULK1"] -.->|"inhibits"| Pi3K["Pi3K"]
    style Pi3K fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (3667)

Target	Relation	Type	Str
AKT	activates	protein	0.95
Glioblastoma Multiforme	upregulates	disease	0.90
Atherosclerosis	biomarker_for	disease	0.60
Cholesterol	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Wnt	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Glycolysis	interacts_with	pathway	0.55
Tgf-Β	interacts_with	pathway	0.55
Complement	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Ferroptosis	interacts_with	pathway	0.55
Dna Methylation	interacts_with	pathway	0.55
Proteasome	interacts_with	pathway	0.55
Toll-Like Receptor	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Angiogenesis	interacts_with	pathway	0.55
Epigenetic	interacts_with	pathway	0.55
Immune Response	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Mitochondrial Function	interacts_with	pathway	0.55
Phagocytosis	interacts_with	pathway	0.55
Insulin Signaling	interacts_with	pathway	0.55
Jak-Stat	interacts_with	pathway	0.55
Synaptic Plasticity	interacts_with	pathway	0.55
Notch	interacts_with	pathway	0.55
Inflammasome	interacts_with	pathway	0.55
Oxidative Stress	interacts_with	pathway	0.55
Inflammasome	therapeutic_target	pathway	0.55
Toll-Like Receptor	therapeutic_target	pathway	0.55
Mapk	biomarker_for	pathway	0.55
Pi3K/Akt	biomarker_for	pathway	0.55
Epigenetic	biomarker_for	pathway	0.55
P2RY12	activates	gene	0.50
Cholesterol	activates	pathway	0.50
mTOR	activates	entity	0.50
RAPAMYCIN	activates	concept	0.50
APOE	activates	gene	0.50
Autophagy	activates	process	0.50
atherosclerosis	activates	disease	0.50
TFEB	activates	protein	0.50
EGFR	activates	gene	0.50
EIF2A	activates	protein	0.50
STING1	activates	protein	0.50
RICTOR	activates	gene	0.50
EIF2AK3	activates	gene	0.50
DDIT3	activates	gene	0.50

Incoming (3525)

Source	Relation	Type	Str
ACTB	inhibits	gene	0.60
P2RY12	inhibits	gene	0.60
APOA1	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
EIF4EBP1	inhibits	gene	0.60
LC3	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
ABCG1	inhibits	gene	0.60
SQSTM1	inhibits	gene	0.60
ABCA1	inhibits	gene	0.60
APOE	inhibits	gene	0.60
LOX	inhibits	gene	0.60
OPTN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR	0.451	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Trem2-dependent Insl3 regulation via Dap12-Syk-PI3K pathway: A new pathogenic me [PMID:41038403]	Ye S, Wu C, Huang S, Fan H, Zhang Z et a	Genomics	2025	0

Pi3K

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

PD Combination Therapy Matrix

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

NTF4 Protein

TREM2 Mechanism Hub

GSK-3β in Neurodegeneration

Growth Factor Therapies

Autophagy Mechanisms

Tau Spreading Mechanism

ncam2

Neurotrophin Signaling Pathways in Neurodegeneration

amyloid-beta-metalloproteinases

TREM2 Microglial Signaling Pathway in Neurodegeneration