Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DREBRIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DBN1 |
| Full Name | Drebrin |
| Chromosome | 17q21.33. |
| Function | Dbn1 — Drebrin is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| GeneCards | DBN1 |
| Human Protein Atlas | DBN1 |
| Actin cytoskeleton | The dynamic protein filament network drebrin organizes |
| Dendritic spines | Postsynaptic structures where drebrin is enriched |
| Cofilin | ADF-family protein regulating actin dynamics alongside drebrin |
| Alzheimer's disease | Primary neurodegenerative condition associated with drebrin loss |
| Synaptic plasticity | Neuronal adaptation process dependent on drebrin function |
| ADF/cofilin proteins | Related actin regulatory molecules |
| Interactions | PRESENILIN, NEURODEGENERATION, ALZHEIMER, AND, NEURON, ALZHEIMER'S DISEASE |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DREBRIN["<b>DREBRIN</b>"]
Alzheimer{"Alzheimer"}
DREBRIN -.->|"inhibits"| Alzheimer
Als{"Als"}
DREBRIN -.->|"inhibits"| Als
Neurodegeneration{"Neurodegeneration"}
DREBRIN -.->|"inhibits"| Neurodegeneration
ALS{"ALS"}
DREBRIN -.->|"inhibits"| ALS
PRESENILIN(["PRESENILIN"])
DREBRIN -.->|"inhibits"| PRESENILIN
Synaptic_Plasticity["Synaptic Plasticity"]
DREBRIN -->|"interacts_with"| Synaptic_Plasticity
ALZHEIMER(["ALZHEIMER"])
ALZHEIMER -.->|"inhibits"| DREBRIN
SYNAPSE(["SYNAPSE"])
SYNAPSE -.->|"inhibits"| DREBRIN
style DREBRIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Neurodegeneration | inhibits | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Nmda Receptor | regulates | protein | 0.60 |
| PRESENILIN | inhibits | gene | 0.60 |
| Synaptic Plasticity | interacts_with | pathway | 0.60 |
| Neuron | interacts_with | cell_type | 0.60 |
| NEURODEGENERATION | inhibits | gene | 0.60 |
| ALZHEIMER | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| NEURON | interacts_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| Actin | interacts_with | protein | 0.60 |
| Ca1 | expressed_in | brain_region | 0.55 |
| Hippocampus | expressed_in | brain_region | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| SYNAPSE | inhibits | concept | 0.50 |
| NMDA | interacts_with | protein | 0.50 |
| SYNAPSE | interacts_with | concept | 0.50 |
| GLUTAMATE | interacts_with | concept | 0.50 |
| NMDA | associated_with | protein | 0.50 |
| NMDA | regulates | protein | 0.50 |
| SYNAPSE | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER | inhibits | gene | 0.60 |
| SYNAPSE | inhibits | gene | 0.60 |
| PRESENILIN | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||