gene

EGLN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGLN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

13Outgoing

3Incoming

0Experiments

0Debates

Summary

EGLN1 encodes PHD2, the key oxygen sensor regulating HIF-alpha stability. Variants cause polycythemia and are implicated in Alzheimer's and Parkinson's disease through hypoxia response pathways.

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🧬 Gene Info

Gene Symbol	EGLN1
Full Name	Egl-9 Family Prolyl Hydroxylase 1
Chromosome	1q42.12
Protein Type	Transcription Factor
Function	regulating HIF-alpha stability
Amino Acids	426 aa
Pathways	NF-κB pathway, Notch signaling
UniProt ID	Q9Y2H5
NCBI Gene ID	54583
Ensembl ID	ENSG00000127837
OMIM	609424
GeneCards	EGLN1
Human Protein Atlas	EGLN1
Associated Diseases	Cancer
Interactions	CANCER, GENES, RNA
KG Connections	16 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EGLN1 — AlphaFold Q9Y2H5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EGLN1 — Egl-9 Family Prolyl Hydroxylase 1

gene · 1645 words

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Pathway Diagram

graph TD
    EGLN1["EGLN1"]
    Ms{"Ms"}
    EGLN1 -->|"interacts with"| Ms
    Cancer{"Cancer"}
    EGLN1 -->|"activates"| Cancer
    Tumor{"Tumor"}
    EGLN1 -->|"interacts with"| Tumor
    neurodegeneration["neurodegeneration"]
    EGLN1 -->|"implicated in"| neurodegeneration
    CANCER["CANCER"]
    CANCER -->|"activates"| EGLN1
    style EGLN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
Tumor	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Cancer	associated_with	disease	0.65
GENES	associated_with	gene	0.60
RNA	regulates	gene	0.60
CANCER	associated_with	gene	0.60
COLORECTAL CANCER	interacts_with	disease	0.50
Microbiota	regulates	process	0.50
cancer	interacts_with	disease	0.50
Gut Microbiota	regulates	process	0.50
GENES	interacts_with	gene	0.50
RNA	interacts_with	gene	0.50

Incoming (3)

Source	Relation	Type	Str
RNA	regulates	gene	0.60
CANCER	activates	gene	0.60
CANCER	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EGLN1 in their description or question text

No additional research found