process

Microbiota

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Microbiota: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

695Connections
1Hypotheses
0Analyses
50Outgoing
50Incoming

No summary available yet. View on Wiki →

🧬 Biological Process Info
NameMicrobiota
Key Genes/ProteinsINFLAMMATION, ALZHEIMER, GENES, MICROGLIA
Related DiseasesAls, Inflammation, Alzheimer
Linked Hypotheses1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Alzheimer's Disease

disease · 5265 words

Blood-Brain Barrier Dysfunction in Neurodegeneration

mechanism · 4726 words

Mitophagy Pathway in Neurodegeneration

mechanism · 4637 words

rankings

general · 4519 words

Blood-Brain Barrier Biology and Crossing Strategies

mechanism · 4474 words

Pathway Diagram

graph TD
    Microbiota["<b>Microbiota</b>"]
    Gut_Brain_Axis["Gut-Brain Axis"]
    Microbiota -->|"regulates"| Gut_Brain_Axis
    Immune_System["Immune System"]
    Microbiota -->|"interacts_with"| Immune_System
    Vagus_Nerve["Vagus Nerve"]
    Microbiota -->|"interacts_with"| Vagus_Nerve
    Enteric_Nervous_System["Enteric Nervous System"]
    Microbiota -->|"interacts_with"| Enteric_Nervous_System
    Microglia["Microglia"]
    Microbiota -->|"activates"| Microglia
    Als{"Als"}
    Als -->|"activates"| Microbiota
    INFLAMMATION(["INFLAMMATION"])
    INFLAMMATION -->|"activates"| Microbiota
    Inflammation{"Inflammation"}
    Inflammation -->|"activates"| Microbiota
    style Microbiota fill:#1a3a4a,stroke:#90a4ae,stroke-width:3px,color:#e0e0e0

Outgoing (86)

TargetRelationTypeStr
Gut-Brain Axisregulatespathway0.95
Gut-Brain Axiscomponent_ofpathway0.95
Glaucomacontributes_todisease0.95
Immune Systeminteracts_withpathway0.90
Vagus Nerveinteracts_withpathway0.90

Incoming (609)

SourceRelationTypeStr
Alsactivatesdisease1.00
INFLAMMATIONactivatesgene1.00
Inflammationactivatesdisease1.00
INFLAMMATIONregulatesgene1.00
Inflammationregulatesdisease1.00

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Microbiota-Microglia Axis Modulation 0.476 neurodegeneration Neuroinflammation and microglial priming

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Biochemistry, Histamine. [PMID:32491722] Patel RH, Rahimi N 2026 0
Ferroptosis and Cuproptosis in Cancer and Neurodegeneration: A Comprehensive Rev [PMID:41897286] ["Tolbatov Iogann", "Marrone Alessandro" Biomolecules 2026 0
Cell death in multiple sclerosis. [PMID:40926029] Guan S, Zhu H, Zhang M, Shi FD, Yan B Cell death and differentiation 2026 0
Astrocytic mGluR5-dependent calcium hyperactivity promotes amyloid-β pathology a [PMID:40377015] Yang T, Zhang D, Huang H, Liu F, Wu J et Brain 2026 0
Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized [PMID:40747850] Saadmaan G, Dalmasso MC, Maria M, Lehtis Brain 2026 0
Reference proteins to improve Core 1 and Core 2 Alzheimer's disease CSF and plas [PMID:41051312] Karlsson L, Janelidze S, Barthélemy NR, Brain 2026 0
Imposter in the brain: aetiological, clinical and neuroimaging characteristics o [PMID:41059767] Watanabe H, Whitwell JL, Bhaskaran JG, L Brain 2026 0
Post-mortem evidence of pathogenic angiogenesis and abnormal vascular function i [PMID:41124599] Asby DJ, Fisher RA, Jackson J, Love S, M Brain 2026 0
A cause and protective treatment for acute and progressive disability and grey m [PMID:41396858] Aguzzi EA, Desai RA, Yang Z, Davies AL, Brain 2026 0
OMG! A proteomic determinant of neurodegenerative resiliency. [PMID:41491993] Duggan MR, Oh HS, Frank P, Gomez GT, Zwe Mol Neurodegener 2026 0
Calycosin ameliorates high-altitude pulmonary edema by regulating macrophage pol [PMID:41534756] Chen Q, Jia N, Zhang X, Liu J, Shen Z et J Ethnopharmacol 2026 0
Gut Dysbiosis and Microbiota-Derived Metabolites in Neurodegenerative Diseases: [PMID:41683467] Czaj PV, Szewczyk-Golec K, Nuszkiewicz J Molecules 2026 0
Conjugated Oligoelectrolytes as Optical Probes. [PMID:41757731] Chan SJW, Zhu JY, Bazan GC Acc Chem Res 2026 0
Bile acid-microbiota interactions in multiple sclerosis: From experimental model [PMID:41806463] Atasever Ü J Neuroimmunol 2026 0
Upconversion-Mediated Phototherapy for Psoriasis Treatment. [PMID:41818318] Ji X, Lin Z, Ding N, Huang W, Ji J et al ACS Appl Bio Mater 2026 0
S-Scheme Shapes Heterojunction Photocatalysis. [PMID:41838418] Sayed M, Zhang L, García H, Yu H, Yu J Acc Chem Res 2026 0
The IL-23/IL-17 axis in Behçet's syndrome pathogenesis: from immunological persp [PMID:41884836] Naffaa ME, Hassan F, Omar M, Abacar K, M Front Immunol 2026 0
Glial Plasticity and Dysfunction: Mechanistic Insights and Therapeutic Opportuni [PMID:41906403] Correale J J Neurochem 2026 0
Inhibitory receptor agonists: Emerging strategies in immune modulation. [PMID:41915422] Adam KR, Suhail A, Kuchroo VK, Vignali D J Exp Med 2026 0
Neurodegeneration and Homelessness: A Bidirectional Relationship Shaping Health [PMID:41918504] Stouffer ACF, Kumar SL Yale J Biol Med 2026 0