Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Microbiota: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Microbiota |
| Key Genes/Proteins | INFLAMMATION, ALZHEIMER, GENES, MICROGLIA |
| Related Diseases | Als, Inflammation, Alzheimer |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
Microbiota["<b>Microbiota</b>"]
Gut_Brain_Axis["Gut-Brain Axis"]
Microbiota -->|"regulates"| Gut_Brain_Axis
Immune_System["Immune System"]
Microbiota -->|"interacts_with"| Immune_System
Vagus_Nerve["Vagus Nerve"]
Microbiota -->|"interacts_with"| Vagus_Nerve
Enteric_Nervous_System["Enteric Nervous System"]
Microbiota -->|"interacts_with"| Enteric_Nervous_System
Microglia["Microglia"]
Microbiota -->|"activates"| Microglia
Als{"Als"}
Als -->|"activates"| Microbiota
INFLAMMATION(["INFLAMMATION"])
INFLAMMATION -->|"activates"| Microbiota
Inflammation{"Inflammation"}
Inflammation -->|"activates"| Microbiota
style Microbiota fill:#1a3a4a,stroke:#90a4ae,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Gut-Brain Axis | regulates | pathway | 0.95 |
| Gut-Brain Axis | component_of | pathway | 0.95 |
| Glaucoma | contributes_to | disease | 0.95 |
| Immune System | interacts_with | pathway | 0.90 |
| Vagus Nerve | interacts_with | pathway | 0.90 |
| Enteric Nervous System | interacts_with | pathway | 0.90 |
| Butyrate | associated_with | compound | 0.90 |
| Microglia | activates | cell_type | 0.85 |
| Autism | associated_with | disease | 0.80 |
| Anxiety | associated_with | disease | 0.80 |
| Schizophrenia | associated_with | disease | 0.80 |
| Parkinson's Disease | associated_with | disease | 0.80 |
| Alzheimer's Disease | associated_with | disease | 0.80 |
| Obesity | associated_with | disease | 0.80 |
| Gut Microbiota | regulates | process | 0.50 |
| Gut Microbiota | activates | process | 0.50 |
| Gut Microbiota | associated_with | process | 0.50 |
| Dysbiosis | interacts_with | disease | 0.50 |
| Gut Microbiota | interacts_with | process | 0.50 |
| Dysbiosis | associated_with | disease | 0.50 |
| Cognitive Impairment | inhibits | phenotype | 0.50 |
| Gut Microbiota | inhibits | process | 0.50 |
| Dysbiosis | causes | disease | 0.50 |
| Gut Microbiota | causes | process | 0.50 |
| Dysbiosis | inhibits | disease | 0.50 |
| SYNUCLEIN | activates | concept | 0.50 |
| Proteins | activates | protein | 0.50 |
| α-SYNUCLEIN | activates | concept | 0.50 |
| SYNUCLEIN | associated_with | concept | 0.50 |
| α-SYNUCLEIN | associated_with | concept | 0.50 |
| Pain | inhibits | disease | 0.50 |
| Pain | regulates | disease | 0.50 |
| Dysbiosis | regulates | disease | 0.50 |
| Dysbiosis | expressed_in | disease | 0.50 |
| Pancreatic Cancer | associated_with | disease | 0.50 |
| CENTRAL NERVOUS SYSTEM | interacts_with | concept | 0.50 |
| Dysbiosis | activates | disease | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| CENTRAL NERVOUS SYSTEM | associated_with | concept | 0.50 |
| GLUTAMATE | associated_with | concept | 0.50 |
| EXCITOTOXICITY | associated_with | concept | 0.50 |
| EXTRACELLULAR VESICLES | associated_with | concept | 0.50 |
| INSULIN | inhibits | concept | 0.50 |
| Sarcopenia | associated_with | disease | 0.50 |
| Gastric Cancer | associated_with | disease | 0.50 |
| Gut Microbiota | expressed_in | process | 0.50 |
| GENE EXPRESSION | expressed_in | concept | 0.50 |
| STEM CELLS | associated_with | concept | 0.50 |
| Cognitive Impairment | activates | phenotype | 0.50 |
| INSULIN | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| ALZHEIMER | regulates | gene | 1.00 |
| Alzheimer | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Als | implicated_in | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| Inflammation | implicated_in | disease | 1.00 |
| NEUROINFLAMMATION | regulates | gene | 1.00 |
| Neuroinflammation | regulates | disease | 1.00 |
| ALZHEIMER'S DISEASE | regulates | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| INFLAMMATION | inhibits | gene | 0.90 |
| Inflammation | inhibits | disease | 0.90 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.90 |
| NF-ΚB | inhibits | gene | 0.90 |
| GUT-BRAIN AXIS | activates | gene | 0.90 |
| IL-6 | activates | gene | 0.90 |
| Obesity | activates | disease | 0.90 |
| Als | treats | disease | 0.90 |
| AUTOPHAGY | regulates | gene | 0.90 |
| TNF | activates | gene | 0.90 |
| TNF-Α | activates | gene | 0.90 |
| Aging | regulates | disease | 0.90 |
| CANCER | activates | gene | 0.90 |
| Cancer | activates | disease | 0.90 |
| Inflammatory Bowel Disease | activates | disease | 0.90 |
| Inflammatory Bowel Disease | therapeutic_target | disease | 0.80 |
| CYTOKINES | inhibits | gene | 0.80 |
| Inflammatory Bowel Disease | regulates | disease | 0.80 |
| ROS | regulates | gene | 0.80 |
| INSULIN RESISTANCE | regulates | gene | 0.80 |
| Insulin Resistance | regulates | disease | 0.80 |
| BDNF | activates | gene | 0.80 |
| AGING | regulates | gene | 0.80 |
| PARKINSON'S DISEASE | activates | gene | 0.80 |
| INFLAMMATION | treats | gene | 0.80 |
| Inflammation | treats | disease | 0.80 |
| NEUROINFLAMMATION | implicated_in | gene | 0.80 |
| Neuroinflammation | implicated_in | disease | 0.80 |
| INFLAMMATION | implicated_in | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microbiota-Microglia Axis Modulation | 0.476 | neurodegeneration | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Biochemistry, Histamine. [PMID:32491722] | Patel RH, Rahimi N | 2026 | 0 | |
| Ferroptosis and Cuproptosis in Cancer and Neurodegeneration: A Comprehensive Rev [PMID:41897286] | ["Tolbatov Iogann", "Marrone Alessandro" | Biomolecules | 2026 | 0 |
| Cell death in multiple sclerosis. [PMID:40926029] | Guan S, Zhu H, Zhang M, Shi FD, Yan B | Cell death and differentiation | 2026 | 0 |
| Astrocytic mGluR5-dependent calcium hyperactivity promotes amyloid-β pathology a [PMID:40377015] | Yang T, Zhang D, Huang H, Liu F, Wu J et | Brain | 2026 | 0 |
| Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized [PMID:40747850] | Saadmaan G, Dalmasso MC, Maria M, Lehtis | Brain | 2026 | 0 |
| Reference proteins to improve Core 1 and Core 2 Alzheimer's disease CSF and plas [PMID:41051312] | Karlsson L, Janelidze S, Barthélemy NR, | Brain | 2026 | 0 |
| Imposter in the brain: aetiological, clinical and neuroimaging characteristics o [PMID:41059767] | Watanabe H, Whitwell JL, Bhaskaran JG, L | Brain | 2026 | 0 |
| Post-mortem evidence of pathogenic angiogenesis and abnormal vascular function i [PMID:41124599] | Asby DJ, Fisher RA, Jackson J, Love S, M | Brain | 2026 | 0 |
| A cause and protective treatment for acute and progressive disability and grey m [PMID:41396858] | Aguzzi EA, Desai RA, Yang Z, Davies AL, | Brain | 2026 | 0 |
| OMG! A proteomic determinant of neurodegenerative resiliency. [PMID:41491993] | Duggan MR, Oh HS, Frank P, Gomez GT, Zwe | Mol Neurodegener | 2026 | 0 |
| Calycosin ameliorates high-altitude pulmonary edema by regulating macrophage pol [PMID:41534756] | Chen Q, Jia N, Zhang X, Liu J, Shen Z et | J Ethnopharmacol | 2026 | 0 |
| Gut Dysbiosis and Microbiota-Derived Metabolites in Neurodegenerative Diseases: [PMID:41683467] | Czaj PV, Szewczyk-Golec K, Nuszkiewicz J | Molecules | 2026 | 0 |
| Conjugated Oligoelectrolytes as Optical Probes. [PMID:41757731] | Chan SJW, Zhu JY, Bazan GC | Acc Chem Res | 2026 | 0 |
| Bile acid-microbiota interactions in multiple sclerosis: From experimental model [PMID:41806463] | Atasever Ü | J Neuroimmunol | 2026 | 0 |
| Upconversion-Mediated Phototherapy for Psoriasis Treatment. [PMID:41818318] | Ji X, Lin Z, Ding N, Huang W, Ji J et al | ACS Appl Bio Mater | 2026 | 0 |
| S-Scheme Shapes Heterojunction Photocatalysis. [PMID:41838418] | Sayed M, Zhang L, García H, Yu H, Yu J | Acc Chem Res | 2026 | 0 |
| The IL-23/IL-17 axis in Behçet's syndrome pathogenesis: from immunological persp [PMID:41884836] | Naffaa ME, Hassan F, Omar M, Abacar K, M | Front Immunol | 2026 | 0 |
| Glial Plasticity and Dysfunction: Mechanistic Insights and Therapeutic Opportuni [PMID:41906403] | Correale J | J Neurochem | 2026 | 0 |
| Inhibitory receptor agonists: Emerging strategies in immune modulation. [PMID:41915422] | Adam KR, Suhail A, Kuchroo VK, Vignali D | J Exp Med | 2026 | 0 |
| Neurodegeneration and Homelessness: A Bidirectional Relationship Shaping Health [PMID:41918504] | Stouffer ACF, Kumar SL | Yale J Biol Med | 2026 | 0 |