protein

VPS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections
0Hypotheses
0Analyses
16Outgoing
19Incoming

Summary

Page for VPS4 Protein

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🔬 Protein Info
Gene SymbolVPS4
FunctionVPS4 (Vacuolar Protein Sorting 4 Homolog) is an AAA+ ATPase that functions in the final stages of multivesicular body (MVB) sorting and autophagy
Primary Expressionneuronal tissues
Amino Acids437 aa
UniProt IDVPS4A
GeneCardsVPS4
Human Protein AtlasVPS4
ApproachStatus
VPS4 activatorsResearch
ESCRT modulatorsPreclinical
Gene therapyResearch
Associated Diseasesneurodegeneration
InteractionsCHMP2B, CHMP4B, CHMP7, VPS4A, ALS, Ras
KG Connections35 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

VPS4 Protein

protein · 678 words

Alpha-Synuclein ESCRT-III Inhibition Mechanism

mechanism · 3574 words

Exosome Biogenesis in Neurodegeneration

mechanism · 3104 words

Extracellular Vesicle-Mediated Synuclein Propagation Hypothesis in Parkinson's Disease

hypothesis · 2963 words

chmp6

gene · 2954 words

VPS35/Retromer Pathway in Parkinson's Disease

mechanism · 2946 words

Pathway Diagram

flowchart TD
    N0["VPS4"]
    N1["Als"]
    N0 -->|"activates"| N1
    N2["ALS"]
    N0 -->|"activates"| N2
    N3["CHMP2B"]
    N0 -->|"interacts with"| N3
    N4["CHMP4B"]
    N0 -->|"interacts with"| N4
    N5["Neuron"]
    N0 -->|"activates"| N5
    N6["CHMP7"]
    N0 -->|"interacts with"| N6
    N7["Ras"]
    N0 -->|"activates"| N7
    N8["App"]
    N0 -->|"interacts with"| N8
    N4 -->|"interacts with"| N0
    N3 -->|"interacts with"| N0
    N9["AND"]
    N9 -->|"interacts with"| N0
    N6 -->|"interacts with"| N0
    N0 -->|"expressed in"| N5
    N10["Proteins"]
    N0 -->|"interacts with"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 gene
    class N6 gene
    class N7 protein
    class N8 protein
    class N9 gene
    class N10 protein

Outgoing (16)

TargetRelationTypeStr
Alsactivatesdisease0.65
CHMP2Binteracts_withgene0.60
CHMP4Binteracts_withgene0.60
CHMP7interacts_withgene0.60
ALSactivatesgene0.60

Incoming (19)

SourceRelationTypeStr
CHMP4Binteracts_withgene0.60
CHMP2Binteracts_withgene0.60
CHMP7interacts_withgene0.60
CHMP7expressed_ingene0.60
CHMP7associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found