Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VPS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | VPS4 |
| Function | VPS4 (Vacuolar Protein Sorting 4 Homolog) is an AAA+ ATPase that functions in the final stages of multivesicular body (MVB) sorting and autophagy |
| Primary Expression | neuronal tissues |
| Amino Acids | 437 aa |
| UniProt ID | VPS4A |
| GeneCards | VPS4 |
| Human Protein Atlas | VPS4 |
| Approach | Status |
| VPS4 activators | Research |
| ESCRT modulators | Preclinical |
| Gene therapy | Research |
| Associated Diseases | neurodegeneration |
| Interactions | CHMP2B, CHMP4B, CHMP7, VPS4A, ALS, Ras |
| KG Connections | 35 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["VPS4"]
N1["Als"]
N0 -->|"activates"| N1
N2["ALS"]
N0 -->|"activates"| N2
N3["CHMP2B"]
N0 -->|"interacts with"| N3
N4["CHMP4B"]
N0 -->|"interacts with"| N4
N5["Neuron"]
N0 -->|"activates"| N5
N6["CHMP7"]
N0 -->|"interacts with"| N6
N7["Ras"]
N0 -->|"activates"| N7
N8["App"]
N0 -->|"interacts with"| N8
N4 -->|"interacts with"| N0
N3 -->|"interacts with"| N0
N9["AND"]
N9 -->|"interacts with"| N0
N6 -->|"interacts with"| N0
N0 -->|"expressed in"| N5
N10["Proteins"]
N0 -->|"interacts with"| N10
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 gene
class N3 gene
class N4 gene
class N6 gene
class N7 protein
class N8 protein
class N9 gene
class N10 protein| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| CHMP2B | interacts_with | gene | 0.60 |
| CHMP4B | interacts_with | gene | 0.60 |
| CHMP7 | interacts_with | gene | 0.60 |
| ALS | activates | gene | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| Ras | activates | protein | 0.60 |
| App | interacts_with | protein | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| VPS4A | interacts_with | gene | 0.55 |
| VPS4A | inhibits | gene | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| Alzheimer's disease | inhibits | disease | 0.55 |
| VPS4A | co_expressed_with | gene | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CHMP4B | interacts_with | gene | 0.60 |
| CHMP2B | interacts_with | gene | 0.60 |
| CHMP7 | interacts_with | gene | 0.60 |
| CHMP7 | expressed_in | gene | 0.60 |
| CHMP7 | associated_with | gene | 0.60 |
| APP | activates | gene | 0.60 |
| CHMP6 | activates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| ALS | expressed_in | gene | 0.60 |
| CHMP2B | associated_with | gene | 0.55 |
| CHMP4B | targets | gene | 0.55 |
| ESCRT-III | interacts_with | gene | 0.55 |
| ATP | regulates | gene | 0.55 |
| CHMP4B | activates | gene | 0.50 |
| CHMP2B | activates | gene | 0.50 |
| CHMP7 | activates | gene | 0.50 |
| CHMP7 | inhibits | gene | 0.50 |
| GSDMD | co_expressed_with | protein | 0.50 |
| MLKL | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||