CHMP3

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHMP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

ESCRT-III core component involved in membrane remodeling, autophagy, and lysosomal degradation - implicated in neurodegeneration

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graph TD
    CHMP3["<b>CHMP3</b>"]
    Dementia{"Dementia"}
    CHMP3 -->|"regulates"| Dementia
    Schizophrenia{"Schizophrenia"}
    CHMP3 -->|"regulates"| Schizophrenia
    Alzheimer{"Alzheimer"}
    CHMP3 -->|"regulates"| Alzheimer
    Multiple_Sclerosis{"Multiple Sclerosis"}
    CHMP3 -->|"regulates"| Multiple_Sclerosis
    Als{"Als"}
    CHMP3 -->|"regulates"| Als
    Cancer{"Cancer"}
    CHMP3 -->|"regulates"| Cancer
    Ms{"Ms"}
    CHMP3 -->|"regulates"| Ms
    PDE4C["PDE4C"]
    CHMP3 -->|"regulates"| PDE4C
    BAG1["BAG1"]
    CHMP3 -->|"regulates"| BAG1
    VTI1B["VTI1B"]
    CHMP3 -->|"regulates"| VTI1B
    EIF4G1["EIF4G1"]
    CHMP3 -->|"activates"| EIF4G1
    NOX1["NOX1"]
    CHMP3 -->|"regulates"| NOX1
    NBN["NBN"]
    NBN -->|"regulates"| CHMP3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| CHMP3
    SGK3["SGK3"]
    SGK3 -->|"regulates"| CHMP3
    TNF["TNF"]
    TNF -->|"regulates"| CHMP3
    CANCER["CANCER"]
    CANCER -->|"regulates"| CHMP3
    SLC24A2["SLC24A2"]
    SLC24A2 -->|"regulates"| CHMP3
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"regulates"| CHMP3
    DNAJC2["DNAJC2"]
    DNAJC2 -->|"regulates"| CHMP3
    style CHMP3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0