CHMP2A

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHMP2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CHMP2A (Charged Multivesicular Body Protein 2A) - ESCRT-III complex component involved in endosomal sorting, autophagy, and neurodegeneration

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graph TD
    CHMP2A["<b>CHMP2A</b>"]
    Alzheimer{"Alzheimer"}
    CHMP2A -->|"activates"| Alzheimer
    Dementia{"Dementia"}
    CHMP2A -->|"activates"| Dementia
    Als{"Als"}
    CHMP2A -->|"activates"| Als
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    CHMP2A -->|"activates"| Frontotemporal_Dementia
    Ftd{"Ftd"}
    CHMP2A -->|"activates"| Ftd
    ALS{"ALS"}
    CHMP2A -->|"activates"| ALS
    CHMP2B["CHMP2B"]
    CHMP2A -->|"activates"| CHMP2B
    CHMP6["CHMP6"]
    CHMP2A -->|"activates"| CHMP6
    Protein_Aggregation(["Protein Aggregation"])
    CHMP2A -->|"activates"| Protein_Aggregation
    neurodegeneration["neurodegeneration"]
    CHMP2A -->|"implicated in"| neurodegeneration
    CHMP6 -->|"activates"| CHMP2A
    CHMP2B -->|"activates"| CHMP2A
    GENES["GENES"]
    GENES -->|"activates"| CHMP2A
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| CHMP2A
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| CHMP2A
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"activates"| CHMP2A
    TAU["TAU"]
    TAU -->|"activates"| CHMP2A
    AND["AND"]
    AND -->|"activates"| CHMP2A
    style CHMP2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0