cell_type

DAM microglia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DAM microglia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

163Connections

1Hypotheses

0Analyses

19Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	DAM microglia
Also Known As	DAM, Activated microglia, AD-associated microglia, ARM (activated response microglia)
Key Pathways	TREM2/DAP12 signaling, PI3K/AKT/mTOR (downstream of TREM2), Phagocytosis (Abeta/tau), Lipid metabolism upregulation, Complement activation
Associated Diseases	Alzheimer's disease (primary), Frontotemporal dementia, ALS, Multiple sclerosis, Parkinson's disease
Related Genes	TREM2, DNA, PINK1
Linked Hypotheses	147 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DAM_microglia["DAM microglia"] -->|"active in"| senescence["senescence"]
    style senescence fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| oxidative_stress_response["oxidative stress response"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| mitochondrial_function["mitochondrial function"]
    style mitochondrial_function fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| autophagy_pathway["autophagy pathway"]
    style autophagy_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| complement_cascade["complement cascade"]
    style complement_cascade fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    DAM_microglia["DAM microglia"] -->|"active in"| NAD__metabolism["NAD+ metabolism"]
    style NAD__metabolism fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    TREM2["TREM2"] -->|"expressed in"| DAM_microglia["DAM microglia"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DNA["DNA"] -->|"expressed in"| DAM_microglia["DAM microglia"]
    style DNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PINK1["PINK1"] -->|"expressed in"| DAM_microglia["DAM microglia"]
    style PINK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    C3["C3"] -->|"expressed in"| DAM_microglia["DAM microglia"]
    style C3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    APOE4["APOE4"] -->|"expressed in"| DAM_microglia["DAM microglia"]
    style APOE4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style DAM_microglia fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (19)

Target	Relation	Type	Str
senescence	active_in	pathway	0.85
oxidative stress response	active_in	pathway	0.85
unfolded protein response	active_in	pathway	0.85
mitochondrial function	active_in	pathway	0.85
autophagy pathway	active_in	pathway	0.85
complement cascade	active_in	pathway	0.85
NAD+ metabolism	active_in	pathway	0.85
epigenetic regulation	active_in	pathway	0.85
ubiquitin-proteasome	active_in	pathway	0.85
insulin signaling	active_in	pathway	0.75
lipid metabolism	active_in	pathway	0.75
purinergic signaling	active_in	pathway	0.75
sphingolipid metabolism	active_in	pathway	0.75
pyroptosis	active_in	pathway	0.75
NF-kB signaling	active_in	pathway	0.65
circadian regulation	active_in	pathway	0.65
ferroptosis	active_in	pathway	0.55
neurotrophin signaling	active_in	pathway	0.55
blood-brain barrier	active_in	pathway	0.55

Incoming (144)

Source	Relation	Type	Str
TREM2	expressed_in	gene	0.85
DNA	expressed_in	gene	0.85
PINK1	expressed_in	gene	0.85
C3	expressed_in	gene	0.85
APOE4	expressed_in	gene	0.85
APOE	expressed_in	gene	0.85
TNF	expressed_in	gene	0.85
GFAP	expressed_in	gene	0.85
NAD	expressed_in	gene	0.85
TDP-43	expressed_in	gene	0.85
RNA	expressed_in	gene	0.85
ROS	expressed_in	gene	0.75
ATP	expressed_in	gene	0.75
P2RY12	expressed_in	gene	0.75
ADAM10	expressed_in	gene	0.75
APOE3	expressed_in	gene	0.75
ALS	expressed_in	gene	0.75
NLRP3	expressed_in	gene	0.75
AQP4	expressed_in	gene	0.75
IL-6	expressed_in	gene	0.75
CD68	expressed_in	gene	0.65
P2X7	expressed_in	gene	0.65
SQSTM1	expressed_in	gene	0.65
LAMP1	expressed_in	gene	0.65
ADAM17	expressed_in	gene	0.65
C1QA	expressed_in	gene	0.65
YKL-40	expressed_in	gene	0.65
PARP1	expressed_in	gene	0.65
H2AX	expressed_in	gene	0.65
TFEB	expressed_in	gene	0.65
SOD1	expressed_in	gene	0.65
AMPK	expressed_in	gene	0.65
CX3CR1	expressed_in	gene	0.65
TMEM119	expressed_in	gene	0.65
APP	expressed_in	gene	0.65
PTEN	expressed_in	gene	0.65
S100B	expressed_in	gene	0.65
ACSL4	expressed_in	gene	0.55
GSH	expressed_in	gene	0.55
SLC7A11	expressed_in	gene	0.55
GPX4	expressed_in	gene	0.55
TFRC	expressed_in	gene	0.55
FTH1	expressed_in	gene	0.55
SNAP-25	expressed_in	gene	0.55
G3BP1	expressed_in	gene	0.55
CR1	expressed_in	gene	0.55
C5	expressed_in	gene	0.55
OPTN	expressed_in	gene	0.55
LDL	expressed_in	gene	0.55
HSP60	expressed_in	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cell-Type Specific TREM2 Upregulation in DAM Microglia	0.519	Alzheimer's Disease	SEA-AD Gene Expression Profiling — Allen

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797]	Zhou Y, Song WM, Andhey PS, Swain A, Lev	Nat Med	2020	1
Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Rec [PMID:41890852]	["Ramirez G", "Hernandez D", "Teal A", "	Research square	2026	0
Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402]	Güven G, Gezegen H, Şahin E, Samancı B,	Acta neurologica Belgica	2026	0
AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973]	Cho S, Zhu R, Kuncewicz K, Duan H, Gabr	Bioorg Med Chem Lett	2026	0
ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody dis [PMID:41490759]	Ishizu H, Hasegawa T, Shimizu T, Yamamot	Bone	2026	0
Oxaliplatin-artesunate conjugate intensifies suppression on colorectal cancer by [PMID:41520444]	Tan Y, Yang T, Jiang S, Li S, Cai L et a	J Inorg Biochem	2026	0
Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750]	Yang X, Zhao Y, Liu W, Feng J, Wu X et a	J Ethnopharmacol	2026	0
Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Func [PMID:41643896]	Chen G, Wang Z, Zhao C, Wang C, Li Y et	Am J Pathol	2026	0
Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180]	Yang FG, Yang H, Han SW, Wang JT, Gao W	Ageing Res Rev	2026	0
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026	0
Triggering Receptor Expressed on Myeloid Cells-2 Regulates Innate Lymphoid Cell [PMID:41928407]	Shen HC, Chen NJ, Sun CY, Yu WK, Su VY e	Kaohsiung J Med Sci	2026	0
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026	0
Hierarchical Targeting of TREM2(+) Myeloid Cells via Acid-Triggered OMVs Reprogr [PMID:41945876]	Chen F, Xue Y, Ma X, Chen L, Shao Z et a	Adv Sci (Weinh)	2026	0
Correction to "A Strategy Involving Microporous Microneedles Integrated with CAR [PMID:41952643]	Unknown	Advanced materials (Deerfield	2026	0
Glycoursodeoxycholic acid regulates peritoneal monocytic myeloid-derived suppres [PMID:41955910]	Wang R, Wang B, Li B, Zhang J, Li Y et a	J Autoimmun	2026	0
A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated [PMID:41957412]	Villani A, Wittmann J, Wyss T, Mallona I	Commun Biol	2026	0
Dual Role of Microglial TREM2 in Neuronal Degeneration and Regeneration After Ax [PMID:41963086]	Pottorf TS, Lane EL, Haley-Johnson Z, Uk	J Neurosci	2026	0
TREM2-mediated microglial phagocytosis of inhibitory synapses contributes to pro [PMID:41965330]	Wang X, Zhou H, Zhai Y, Zhang Y, Cheng Y	Cell Death Discov	2026	0
Population-scale burden analysis of rare damaging coding variants identifies nov [PMID:41867223]	Le Guen Y, Peña-Tauber A, Pulgrossi RC,	medRxiv : the preprint server	2026	0
TREM2 as a possible link between Alzheimer's disease and diabetes mellitus. [PMID:41862118]	Chen W, Huang N, Huang W, Wang M, Luo Y,	Experimental neurology	2026	0

DAM microglia

Understanding Entity Pages

Wiki Pages (20)

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Nanomedicine Approaches to Alzheimer's Disease

Metal Homeostasis Dysfunction Comparison Across Neurodegenerative Diseases

PRX005

msa-pathophysiology-disease-mechanisms

Calcium Signaling Dysregulation in Alzheimer's Disease

AMPA Receptor Neurons

TREM2 Signaling in Neurodegeneration

Golgi Apparatus Stress Comparison Across Neurodegenerative Diseases

Microglial Phagocytosis in Neurodegeneration

Microglia Activation Mechanism

Neuroinflammation Pathway

brain-computer-interface

trem2-therapeutics

Microglia

Brain Pericytes in Neurodegeneration

Microglia and neuroinflammation in Alzheimer's Disease

Brain-Computer Interface Technologies