protein

FYNPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FYNPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Fyn — Proto Oncogene Tyrosine Protein Kinase Fyn is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	FYNPROTEIN
Chromosome	6q21.
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neurons, oligodendrocytes, and astrocytes, where it regulates myelination, synaptic plasticity, and [NMDA
Subcellular Localization	through palmitoylation cycles, trafficking between the Golgi apparatus, plasma m
Molecular Weight	59 kDa
GeneCards	FYNPROTEIN
Human Protein Atlas	FYNPROTEIN
Unique domain (residues 1-85)	Contains Fyn-specific sequences that mediate unique protein interactions, including binding to myelin proteins
SH3 domain (residues 85-143)	Binds proline-rich motifs; participates in autoinhibitory conformation
SH2 domain (residues 150-225)	Binds phosphotyrosine residues on regulatory proteins
C-terminal tail	Tyr531 (human) is phosphorylated by CSK for autoinhibition
Process extension	Promotes oligodendrocyte process outgrowth and wrapping around axons
Fyn knockout phenotype	Mice lacking Fyn show hypomyelination, tremors, and motor coordination deficits (Umemori et al., 1994)[@umemori1994]
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Interactions	Actin, AD, ADRB2, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX Hypotheses	FYN-Mediated Extracellular Vesicle Release Inhibit
KG Connections	443 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Fyn — Proto-Oncogene Tyrosine-Protein Kinase Fyn

protein · 1168 words

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Pathway Diagram

graph TD
    FYNPROTEIN["FYNPROTEIN"]
    neurodegeneration["neurodegeneration"]
    FYNPROTEIN -->|"implicated_in"| neurodegeneration
    style FYNPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning FYNPROTEIN in their description or question text

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