Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GASDERMIN E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GASDERMIN E |
| Molecular Weight | 55.4 kDa |
| Amino Acids | 496 aa |
| Pathways | Pyroptosis |
| Interactions | GASDERMIN, GSDME, CASPASE-3 |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GASDERMIN_E("GASDERMIN E")
cancer{"cancer"}
GASDERMIN_E -->|"activates"| cancer
TUMOR{"TUMOR"}
GASDERMIN_E -->|"activates"| TUMOR
CELL_DEATH["CELL DEATH"]
GASDERMIN_E -->|"activates"| CELL_DEATH
BREAST_CANCER{"BREAST CANCER"}
GASDERMIN_E -->|"activates"| BREAST_CANCER
METASTASIS["METASTASIS"]
GASDERMIN_E -->|"activates"| METASTASIS
GASDERMIN["GASDERMIN"]
GASDERMIN_E -->|"activates"| GASDERMIN
Reactive_Oxygen_Species["Reactive Oxygen Species"]
GASDERMIN_E -->|"activates"| Reactive_Oxygen_Species
apoptosis["apoptosis"]
GASDERMIN_E -->|"expressed_in"| apoptosis
Pyroptosis(["Pyroptosis"])
GASDERMIN_E -->|"expressed_in"| Pyroptosis
GASDERMIN_E -->|"expressed_in"| GASDERMIN
GSDME["GSDME"]
GSDME -->|"activates"| GASDERMIN_E
CASPASE_3("CASPASE-3")
CASPASE_3 -->|"activates"| GASDERMIN_E
GSDME -->|"expressed_in"| GASDERMIN_E| Target | Relation | Type | Str |
|---|---|---|---|
| cancer | activates | disease | 0.50 |
| TUMOR | activates | disease | 0.50 |
| CELL DEATH | activates | concept | 0.50 |
| BREAST CANCER | activates | disease | 0.50 |
| GASDERMIN | activates | gene | 0.50 |
| Reactive Oxygen Species | activates | process | 0.50 |
| apoptosis | expressed_in | process | 0.50 |
| Pyroptosis | expressed_in | pathway | 0.50 |
| GASDERMIN | expressed_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||