protein

GASDERMIN E

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GASDERMIN E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections
0Hypotheses
0Analyses
9Outgoing
3Incoming

Summary

Page for Gasdermin E Protein

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🔬 Protein Info
Gene SymbolGASDERMIN E
Molecular Weight55.4 kDa
Amino Acids496 aa
PathwaysPyroptosis
InteractionsGASDERMIN, GSDME, CASPASE-3
KG Connections12 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (10)

Knowledge base pages for this entity

Caspase-3 Protein

protein · 2770 words

Pyroptosis

mechanism · 2592 words

Necroptosis in Alzheimer's Disease

mechanism · 2534 words

Pyroptosis in Neurodegeneration

mechanism · 2342 words

GSDME — Gasdermin E

gene · 1996 words

Pathway Diagram

graph TD
    GASDERMIN_E("GASDERMIN E")
    cancer{"cancer"}
    GASDERMIN_E -->|"activates"| cancer
    TUMOR{"TUMOR"}
    GASDERMIN_E -->|"activates"| TUMOR
    CELL_DEATH["CELL DEATH"]
    GASDERMIN_E -->|"activates"| CELL_DEATH
    BREAST_CANCER{"BREAST CANCER"}
    GASDERMIN_E -->|"activates"| BREAST_CANCER
    METASTASIS["METASTASIS"]
    GASDERMIN_E -->|"activates"| METASTASIS
    GASDERMIN["GASDERMIN"]
    GASDERMIN_E -->|"activates"| GASDERMIN
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    GASDERMIN_E -->|"activates"| Reactive_Oxygen_Species
    apoptosis["apoptosis"]
    GASDERMIN_E -->|"expressed_in"| apoptosis
    Pyroptosis(["Pyroptosis"])
    GASDERMIN_E -->|"expressed_in"| Pyroptosis
    GASDERMIN_E -->|"expressed_in"| GASDERMIN
    GSDME["GSDME"]
    GSDME -->|"activates"| GASDERMIN_E
    CASPASE_3("CASPASE-3")
    CASPASE_3 -->|"activates"| GASDERMIN_E
    GSDME -->|"expressed_in"| GASDERMIN_E

Outgoing (9)

TargetRelationTypeStr
canceractivatesdisease0.50
TUMORactivatesdisease0.50
CELL DEATHactivatesconcept0.50
BREAST CANCERactivatesdisease0.50
GASDERMINactivatesgene0.50

Incoming (3)

SourceRelationTypeStr
GSDMEactivatesgene0.50
CASPASE-3activatesprotein0.50
GSDMEexpressed_ingene0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found