Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TUMOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | AGING, AKT, AKT1, ALZHEIMER'S DISEASE, AMYLOID, APOE, APOPTOSIS, APP |
| KG Connections | 1177 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
TUMOR["TUMOR"]
UBIQUITIN(["UBIQUITIN"])
TUMOR -->|"causes"| UBIQUITIN
ULK1(["ULK1"])
TUMOR -->|"causes"| ULK1
VEGF(["VEGF"])
TUMOR -->|"activates"| VEGF
TP53(["TP53"])
TP53 -->|"associated_with"| TUMOR
MAGI2(["MAGI2"])
MAGI2 -->|"associated_with"| TUMOR
INSULIN_RESISTANCE["INSULIN RESISTANCE"]
INSULIN_RESISTANCE -->|"associated_with"| TUMOR
ER_STRESS["ER STRESS"]
ER_STRESS -->|"associated_with"| TUMOR
style TUMOR fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Oxidative Stress | associated_with | pathway | 1.00 |
| Lung Cancer | associated_with | disease | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Apoptosis | associated_with | pathway | 1.00 |
| Glycolysis | associated_with | pathway | 1.00 |
| Carcinoma | associated_with | disease | 1.00 |
| Diabetes | therapeutic_target | disease | 1.00 |
| Phagocytosis | activates | pathway | 1.00 |
| Senescence | associated_with | disease | 1.00 |
| Prostate Cancer | associated_with | disease | 1.00 |
| Infection | associated_with | disease | 1.00 |
| Infection | therapeutic_target | disease | 1.00 |
| Immune Checkpoint | inhibits | pathway | 1.00 |
| Als | associated_with | disease | 1.00 |
| Immune Response | regulates | pathway | 1.00 |
| Autoimmune | therapeutic_target | disease | 1.00 |
| Prostate Cancer | activates | disease | 1.00 |
| Cardiovascular | therapeutic_target | disease | 1.00 |
| Ovarian Cancer | therapeutic_target | disease | 1.00 |
| Stem Cell | activates | pathway | 1.00 |
| Carcinoma | expressed_in | disease | 1.00 |
| Epithelial-Mesenchymal Transition | activates | pathway | 1.00 |
| Lymphoma | therapeutic_target | disease | 1.00 |
| Proteasome | therapeutic_target | pathway | 1.00 |
| Angiogenesis | activates | pathway | 1.00 |
| Lung Cancer | therapeutic_target | disease | 1.00 |
| Autophagy | regulates | pathway | 1.00 |
| Leukemia | therapeutic_target | disease | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Infection | regulates | disease | 1.00 |
| Glycolysis | therapeutic_target | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Oxidative Phosphorylation | therapeutic_target | pathway | 1.00 |
| Microrna | therapeutic_target | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Wnt | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Epigenetic | inhibits | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Cell Cycle | inhibits | pathway | 1.00 |
| Mtor | inhibits | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Als | inhibits | disease | 1.00 |
| Metastasis | causes | pathway | 1.00 |
| Checkpoint Inhibitor | therapeutic_target | pathway | 1.00 |
| Autophagy | inhibits | pathway | 1.00 |
| Chemoresistance | therapeutic_target | pathway | 1.00 |
| Mtor | regulates | pathway | 1.00 |
| Senescence | activates | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NF-ΚB | activates | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| CANCER | interacts_with | gene | 1.00 |
| PINK1 | activates | gene | 1.00 |
| IL-6 | activates | gene | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| DNA | biomarker_for | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| FERROPTOSIS | inhibits | gene | 1.00 |
| PI3K | inhibits | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| ERK | inhibits | gene | 1.00 |
| MYC | inhibits | gene | 1.00 |
| AKT | inhibits | gene | 1.00 |
| P62 | inhibits | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| STAT3 | therapeutic_target | gene | 1.00 |
| MYC | regulates | gene | 1.00 |
| BAX | therapeutic_target | gene | 1.00 |
| BCL-2 | therapeutic_target | gene | 1.00 |
| TLR4 | inhibits | gene | 1.00 |
| GENES | regulates | gene | 1.00 |
| AMPK | therapeutic_target | gene | 1.00 |
| ERK | therapeutic_target | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| JUN | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| SIRT1 | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| SLC7A11 | activates | gene | 1.00 |
| ERK | activates | gene | 1.00 |
| TNF | expressed_in | gene | 1.00 |
| LC3 | activates | gene | 1.00 |
| AKT | associated_with | gene | 1.00 |
| MICRORNAS | expressed_in | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| LC3 | inhibits | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| BRAF | therapeutic_target | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| KRAS | inhibits | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| SQSTM1 | activates | gene | 1.00 |
| UBIQUITIN | activates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CyclinD1-Tagged Partial Cellular Reprogramming via Modified | 0.530 | neurodegeneration | - |
| Tumor-derived extracellular vesicles as TREM2 ligands | 0.490 | neurodegeneration | Does the cancer-cystatin-C-TREM2 pathway |
| Epigenetic Silencing of Tumor Suppressor Genes in Cancer Pro | 0.438 | - | - |
| Direct C1q Binding Enables FcγR-Independent Complement Activ | 0.148 | molecular-biology | Does Alectinib truly bind C1q directly w |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TUMOR in their description or question text
No additional research found