gene

GASDERMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GASDERMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

571Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	GSDM family
Full Name	Gasdermin family
Aliases	GSDMA, GSDMB, GSDMC, GSDMD, GSDME
Function	Pore-forming proteins executing pyroptosis. GSDMD is cleaved by inflammatory caspases to form membrane pores.
Primary Expression	Macrophages, monocytes, microglia, neurons
Gene Type	Protein-coding gene family
Pathways	Pyroptosis, Inflammasome signaling, NLRP3 pathway
Associated Diseases	ALS, Alzheimer, Infection, Inflammation, Ms
Interactions	TNF, NEUROINFLAMMATION, PYROPTOSIS, AND, ASC, NEURON
KG Connections	569 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GASDERMIN["GASDERMIN"] -.->|"inhibits"| Inflammation["Inflammation"]
    GASDERMIN["GASDERMIN"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    GASDERMIN["GASDERMIN"] -->|"associated"| Inflammation_1["Inflammation"]
    GASDERMIN["GASDERMIN"] -->|"activates"| Stroke["Stroke"]
    GASDERMIN["GASDERMIN"] -->|"activates"| Inflammation_2["Inflammation"]
    GASDERMIN["GASDERMIN"] -->|"associated"| Infection["Infection"]
    CANCER["CANCER"] -.->|"inhibits"| GASDERMIN["GASDERMIN"]
    CELL_DEATH["CELL DEATH"] -->|"activates"| GASDERMIN["GASDERMIN"]
    CELL_DEATH_3["CELL DEATH"] -->|"causes"| GASDERMIN["GASDERMIN"]
    APOPTOSIS["APOPTOSIS"] -->|"degrades"| GASDERMIN["GASDERMIN"]
    style GASDERMIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (356)

Target	Relation	Type	Str
Inflammation	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Stroke	activates	disease	0.65
Inflammation	activates	disease	0.65
Infection	associated_with	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Infection	activates	disease	0.65
Als	associated_with	disease	0.65
Infection	regulates	disease	0.65
Als	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Autoimmune	regulates	disease	0.65
Melanoma	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Sepsis	activates	disease	0.65
NLRP3	activates	gene	0.65
NLRP3	degrades	gene	0.65
TEMPORAL LOBE	degrades	brain_region	0.65
MLKL	mediates	gene	0.65
Inflammation	causes	disease	0.65
Parkinson	causes	disease	0.65
Neuroinflammation	causes	disease	0.65
Ms	causes	disease	0.65
Alzheimer	causes	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Cancer	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Dementia	activates	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Stroke	regulates	disease	0.65

Incoming (215)

Source	Relation	Type	Str
CANCER	inhibits	disease	0.60
INFLAMMATION	inhibits	gene	0.60
TAK1	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
AND	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
ROS	inhibits	gene	0.60
MYD88	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
TRAF6	inhibits	gene	0.60
INFLAMMATION	associated_with	gene	0.60
NLRP3	activates	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
STROKE	activates	gene	0.60
AND	associated_with	gene	0.60
MICROGLIA	activates	gene	0.60
BRAIN INJURY	activates	gene	0.60
GENES	activates	gene	0.60
STING	activates	gene	0.60
GSDMD	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
AND	activates	gene	0.60
CANCER	activates	gene	0.60
GSDME	activates	gene	0.60
INFLAMMATION	regulates	gene	0.60
PYROPTOSIS	regulates	gene	0.60
AND	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
CANCER	regulates	gene	0.60
GSDMD	regulates	gene	0.60
PYROPTOSIS	activates	gene	0.60
OVERVIEW	regulates	gene	0.60
CYTOKINES	activates	gene	0.60
GSDMD	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
NLRP3	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AMYLOID	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
OVERVIEW	activates	gene	0.60
HMGB1	regulates	gene	0.60
DNA	activates	gene	0.60
ZBP1	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GASDERMIN

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

neuroinflammation

nlrc5-protein

Pannexin 1 and P2X7 Receptor Signaling in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Ferroptosis in Neurodegeneration

Neuroinflammation Microglia

NLRP3 Inflammasome Activation Pathway in Neurodegeneration

Neuroinflammation in Alzheimer's Disease

DNA Sensing Pathways in Neurodegeneration

Apoptosis in Neurodegeneration

Neuroinflammation and Microglia Pathway

ASC (PYCARD)

Neuroinflammation Comparison — AD/PD/ALS/FTD/HD

nlrp3-inflammasome

Ferroptosis

Caspase-3 Protein

IL-1α Protein