disease

BREAST CANCER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BREAST CANCER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1134Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	AKT, MCOLN1, AKT1, PTEN, PIK3CA, SLC16A1, RHOT1, PRMT5
Therapeutic Agents	CISPLATIN
KG Connections	293 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    BREAST_CANCER["BREAST CANCER"] -.->|"inhibits"| CELL_PROLIFERATION["CELL PROLIFERATION"]
    style CELL_PROLIFERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -.->|"inhibits"| CDK4["CDK4"]
    style CDK4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -.->|"inhibits"| LONG_NON_CODING_RNA["LONG NON-CODING RNA"]
    style LONG_NON_CODING_RNA fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -.->|"inhibits"| FERROPTOSIS["FERROPTOSIS"]
    style FERROPTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -->|"activates"| PI3K["PI3K"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -->|"activates"| AKT["AKT"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BREAST_CANCER["BREAST CANCER"] -->|"activates"| ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"]
    style ENDOTHELIAL_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CTDNA["CTDNA"] -->|"biomarker for"| BREAST_CANCER["BREAST CANCER"]
    style CTDNA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FERROPTOSIS_1["FERROPTOSIS"] -->|"associated"| BREAST_CANCER["BREAST CANCER"]
    style FERROPTOSIS_1 fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    METASTASIS["METASTASIS"] -->|"regulates"| BREAST_CANCER["BREAST CANCER"]
    style METASTASIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    AKT_2["AKT"] -->|"causes"| BREAST_CANCER["BREAST CANCER"]
    style AKT_2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    APP["APP"] -.->|"inhibits"| BREAST_CANCER["BREAST CANCER"]
    style APP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style BREAST_CANCER fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (397)

Target	Relation	Type	Str
CELL PROLIFERATION	inhibits	process	0.50
CDK4	inhibits	gene	0.50
LONG NON-CODING RNA	inhibits	process	0.50
Chemoresistance	causes	pathway	0.50
Chemoresistance	associated_with	pathway	0.50
Gastric Cancer	associated_with	disease	0.50
Melanoma	associated_with	disease	0.50
HER2	activates	concept	0.50
HER2	inhibits	concept	0.50
GENE EXPRESSION	interacts_with	concept	0.50
Reactive Oxygen Species	regulates	process	0.50
Microrna	associated_with	pathway	0.50
GASDERMIN	activates	gene	0.50
Reactive Oxygen Species	activates	process	0.50
Prostate Cancer	activates	disease	0.50
Lung Cancer	associated_with	disease	0.50
Proteins	interacts_with	protein	0.50
PI3K/AKT/mTOR	causes	pathway	0.50
HER2	expressed_in	concept	0.50
HER2	associated_with	concept	0.50
PI3K/AKT/mTOR	inhibits	pathway	0.50
CELL SURVIVAL	associated_with	concept	0.50
PI3K/AKT/mTOR	associated_with	pathway	0.50
Drug Resistance	activates	pathway	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
HER2	causes	concept	0.50
Microbiota	associated_with	process	0.50
Gut Microbiota	associated_with	process	0.50
Tumor Microenvironment	activates	process	0.50
SRPK1	associated_with	concept	0.50
SRPK1	regulates	concept	0.50
SRPK1	expressed_in	concept	0.50
CX43	associated_with	concept	0.50
Lung Cancer	interacts_with	disease	0.50
Invasion	associated_with	pathway	0.50
Invasion	activates	pathway	0.50
Epithelial-Mesenchymal Transition	activates	process	0.50
PPARG	associated_with	gene	0.50
NICOTINAMIDE	associated_with	drug	0.50
RIBOCICLIB	associated_with	drug	0.50
CTSD	associated_with	gene	0.50
RAPAMYCIN	associated_with	drug	0.45
SIROLIMUS	associated_with	drug	0.45
PALBOCICLIB	associated_with	drug	0.45
CISPLATIN	associated_with	drug	0.45
MTOR PATHWAY	associated_with	pathway	0.45
MDM2	associated_with	gene	0.45
JNK	associated_with	gene	0.45
LUTEOLIN	associated_with	drug	0.45
MMP9	associated_with	gene	0.45

Incoming (737)

Source	Relation	Type	Str
CTDNA	biomarker_for	entity	0.80
OBESITY	increases_risk	disease	0.65
EGFR	regulates	gene	0.65
JNK	regulates	gene	0.65
CISPLATIN	treats	drug	0.65
NEURONS	activates	cell_type	0.65
OBESITY	exacerbates	disease	0.65
MTOR PATHWAY	inhibits	pathway	0.65
LUTEOLIN	inhibits	drug	0.65
NICOTINAMIDE	inhibits	drug	0.65
ARID1A	causes	gene	0.65
ARID1A	sensitizes_to	gene	0.65
RIBOCICLIB	inhibits	drug	0.65
CANCER	depleted_in	disease	0.55
cancer	associated_with	disease	0.50
cancer	causes	disease	0.50
PHGDH	causes	concept	0.50
PRMT1	causes	concept	0.50
Autophagy	associated_with	process	0.50
MCOLN1	associated_with	gene	0.50
Glioma	associated_with	disease	0.50
cancer	activates	disease	0.50
ENDOTHELIAL	activates	concept	0.50
ferroptosis	activates	phenotype	0.50
HIPPO	activates	concept	0.50
UFM1	activates	gene	0.50
TUMOR	activates	disease	0.50
C-JUN	activates	protein	0.50
apoptosis	activates	process	0.50
cancer	inhibits	disease	0.50
Stem Cell	inhibits	cell_type	0.50
CD44	inhibits	gene	0.50
cancer	regulates	disease	0.50
Stem Cell	regulates	cell_type	0.50
cancer	expressed_in	disease	0.50
cancer	interacts_with	disease	0.50
Dna Repair	regulates	pathway	0.50
oxidative stress	activates	phenotype	0.50
DNA DAMAGE	activates	concept	0.50
TUMOR	associated_with	disease	0.50
DEPDC5	inhibits	gene	0.50
GSDME	activates	gene	0.50
CASPASE-3	activates	protein	0.50
Pyroptosis	activates	pathway	0.50
GASDERMIN E	activates	protein	0.50
CELL DEATH	activates	concept	0.50
GSDME	inhibits	gene	0.50
MMP9	inhibits	gene	0.50
mTOR	inhibits	entity	0.50
Pi3K	activates	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BREAST CANCER

Understanding Entity Pages

Wiki Pages (20)

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