| Gene Symbol | GSDME |
| Full Name | GSDME — Gasdermin E |
| Aliases | Gasdermin E/DFNA5 |
| Chromosome | 7p15.3 |
| Protein Type | Gene |
| Function | Caspase-3 cleavage: Unlike GSDMD, GSDME is cleaved by executioner caspase-3 |
| Primary Expression | cochlea, brain, and other tissues |
| Molecular Weight | 55 kDa |
| Amino Acids | 496 aa |
| Exons | 12 |
| Pathways | Pyroptosis |
| UniProt ID | [O60443](https://www.uniprot.org/uniprotkb/O60443) |
| NCBI Gene ID | Search NCBI |
| GeneCards | GSDME |
| Human Protein Atlas | GSDME |
| Associated Diseases | Amyotrophic Lateral Sclerosis, Axon Loss, Cancer, Frontotemporal Dementia, Melanoma, Pyroptosis |
| Known Drugs/Compounds | Celastrol, XHP |
| Interactions | STAT3, CD8, STING, DRP1, UBIQUITIN, SIRT1 |
| KG Connections | 263 knowledge graph edges |
| Databases | GeneCardsHPASTRING |