protein

GNAI3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNAI3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	GNAI3PROTEIN
Chromosome	1p31.3.
Protein Family	Gαi/o/t family
Function	is a member of the Gαi family of heterotrimeric G proteins encoded by the GNAI3 gene on chromosome 1p31.
Primary Expression	Ubiquitous; highest in brain, heart, spleen
Subcellular Localization	Plasma membrane, cytoplasm, Golgi apparatus
Molecular Weight	40.4 kDa (354 amino acids)
Amino Acids	354 aa
UniProt ID	P08754
GeneCards	GNAI3PROTEIN
Human Protein Atlas	GNAI3PROTEIN
Gene	GNAI3
PDB	1Y3A, 4G5O, 6CRK
Adenylyl cyclase	Inhibition
GIRK channels	Activation
Associated Diseases	Als, Ms
Interactions	AKT, AKT1, GNB1, AMPD2, ATG5, MAVS
KG Connections	57 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GNAI3PROTEIN — AlphaFold P08754 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GNAI3 (G Protein Alpha i3)

protein · 1171 words

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Pathway Diagram

graph TD
    GNAI3PROTEIN["GNAI3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GNAI3PROTEIN -->|"implicated_in"| neurodegeneration
    style GNAI3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity