Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GRIK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GRIK3 |
| Full Name | Glutamate Ionotropic Kainate Type Subunit 3 |
| Aliases | Page for GRIK3, Page for GRIK3 Protein |
| Chromosome | 1p36 |
| Protein Family | Ionotropic glutamate receptor (kainate) |
| Protein Type | Receptor |
| Function | GRIK3 encodes the GluR7 kainate receptor subunit: |
| Primary Expression | the brain and plays roles in synaptic transmission, neuronal excitability, and information processing |
| Molecular Weight | ~100 kDa |
| Amino Acids | 890 aa |
| UniProt ID | Q16478 |
| NCBI Gene ID | 2899 |
| Ensembl ID | ENSG00000136243 |
| OMIM | 138245 |
| GeneCards | GRIK3 |
| Human Protein Atlas | GRIK3 |
| Associated Diseases | neurodegeneration |
| Interactions | SRC, GRID2, PDGFRA, ERK, CANCER, NEURON |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GRIK3["<b>GRIK3</b>"]
Cancer{"Cancer"}
GRIK3 -->|"activates"| Cancer
Tumor{"Tumor"}
GRIK3 -->|"activates"| Tumor
ERK["ERK"]
GRIK3 -->|"activates"| ERK
SRC["SRC"]
GRIK3 -->|"activates"| SRC
GRID2["GRID2"]
GRIK3 -->|"activates"| GRID2
PDGFRA["PDGFRA"]
GRIK3 -->|"inhibits"| PDGFRA
CANCER["CANCER"]
GRIK3 -->|"activates"| CANCER
AND["AND"]
GRIK3 -->|"activates"| AND
neurodegeneration["neurodegeneration"]
GRIK3 -->|"implicated in"| neurodegeneration
GRID2 -->|"activates"| GRIK3
NEURON["NEURON"]
NEURON -->|"activates"| GRIK3
ERK -->|"activates"| GRIK3
RAS["RAS"]
RAS -->|"activates"| GRIK3
style GRIK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||