gene

PDGFRA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDGFRA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

105Connections
1Hypotheses
0Analyses
50Outgoing
33Incoming

Summary

Page for PDGFRA - Platelet Derived Growth Factor Receptor Alpha

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🧬 Gene Info
Gene SymbolPDGFRA
Full NamePDGFRA - Platelet Derived Growth Factor Receptor Alpha
AliasesPage for PDGFRA
Chromosome4q12
Protein TypeGene
FunctionPDGFRA signaling regulates cell proliferation, migration, and survival during development and tissue repair [@uniprot]:
Primary Expressionmesenchymal cells including fibroblasts, smooth muscle cells, and glial progenitors [@references]
Molecular Weight180 kDa
Amino Acids1086 aa
Exons23
PathwaysAkt, Differentiation, MAPK signaling, ubiquitin-proteasome
NCBI Gene IDSearch NCBI
GeneCardsPDGFRA
Human Protein AtlasPDGFRA
Associated DiseasesALS, Cancer, Carcinoma, Glioma, Tumor
InteractionsPDGFRB, IL6R, AKT, EPHA2, GBM, PDGFA
SciDEX HypothesesOPC differentiation blockade contributes to white
KG Connections105 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

PDGFRA - Platelet Derived Growth Factor Receptor Alpha

gene · 630 words

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

mechanism · 3583 words

Oligodendrocyte Precursor Differentiation Failure in Neurodegeneration

mechanism · 2577 words

Oligodendrocyte-Myelin Dysfunction Hypothesis in Parkinson's Disease

hypothesis · 2351 words

PTPRF Protein

protein · 2147 words

Gliogenesis in Neurodegeneration

mechanism · 2034 words

Pathway Diagram

graph TD
    PDGFRA["<b>PDGFRA</b>"]
    Ms{"Ms"}
    PDGFRA -->|"interacts with"| Ms
    Als{"Als"}
    PDGFRA -->|"regulates"| Als
    Cancer{"Cancer"}
    PDGFRA -->|"activates"| Cancer
    Tumor{"Tumor"}
    PDGFRA -->|"activates"| Tumor
    PDGFRA -->|"associated with"| Cancer
    Carcinoma{"Carcinoma"}
    PDGFRA -->|"associated with"| Carcinoma
    PDGFRA -->|"inhibits"| Ms
    Glioblastoma{"Glioblastoma"}
    PDGFRA -->|"therapeutic target"| Glioblastoma
    ALS{"ALS"}
    PDGFRA -->|"regulates"| ALS
    PDGFRB["PDGFRB"]
    PDGFRA -->|"interacts with"| PDGFRB
    P53["P53"]
    PDGFRA -->|"regulates"| P53
    THBS2["THBS2"]
    PDGFRA -->|"associated with"| THBS2
    GLI1["GLI1"]
    GLI1 -->|"regulates"| PDGFRA
    PDGFRB -->|"interacts with"| PDGFRA
    P53 -->|"regulates"| PDGFRA
    GRIK3["GRIK3"]
    GRIK3 -->|"inhibits"| PDGFRA
    ERK["ERK"]
    ERK -->|"inhibits"| PDGFRA
    SRC["SRC"]
    SRC -->|"activates"| PDGFRA
    GRID2["GRID2"]
    GRID2 -->|"inhibits"| PDGFRA
    THBS2 -->|"regulates"| PDGFRA
    NEURON["NEURON"]
    NEURON -->|"activates"| PDGFRA
    RAS["RAS"]
    RAS -->|"inhibits"| PDGFRA
    CANCER["CANCER"]
    CANCER -->|"activates"| PDGFRA
    AND["AND"]
    AND -->|"inhibits"| PDGFRA
    style PDGFRA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (72)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
Tumoractivatesdisease0.75
Msinteracts_withdisease0.65
Alsregulatesdisease0.65
Canceractivatesdisease0.65

Incoming (33)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
h_seaad_004targets_genehypothesis0.90
GLI1regulatesgene0.60
PDGFRBinteracts_withgene0.60
GRIK3inhibitsgene0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
OPC differentiation blockade contributes to white matter deg 0.495 Alzheimer's disease SEA-AD Single-Cell Analysis: Cell-Type V

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Cancer-Associated Fibroblasts Promote Imatinib Resistance in Gastrointestinal St [PMID:41270149] Li C, Teng T, Lin X, Sun X, Yi T et al. Cancer Res 2026 0
A cellular epigenetic classification system for glioblastoma. [PMID:41499453] Silverbush D, Jürgensen L, Freeburg NF, Neuro Oncol 2026 0
Gastrointestinal Stromal Tumors: Molecular Mechanisms of Drug Resistance and Adv [PMID:41724491] Jingnuo D, Huachuan Z, Da Z, Zhi D, Yan J Gastroenterol Hepatol 2026 0
P16(+) Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated [PMID:41766526] Yan L, Zheng J, Lu Z, Zhu A, Ye M et al. Circulation 2026 0
Multi-omics reveals heterogeneity and functional populations of oligodendrocyte [PMID:41771834] Ye D, Zhou H, Qu S, Wang Z, Zhang F et a Cell Death Discov 2026 0
Comparison of gene fusion detection algorithms reveals frequently overlooked dri [PMID:41935182] Tamura Z, Saito Y, Kogure Y, Oshikawa-Ku NPJ Precis Oncol 2026 0
Single-cell transcriptome analysis indicated that immune-related programmed cell [PMID:41946148] Sun J, Jing L, Zhu X, Yang H, Sun Y et a Transl Oncol 2026 0
Lipid emulsion modulates myogenic and collagen-related gene expression in skelet [PMID:41955312] Li X, Alaniz SM, Louey S, Deavila JM, Jo Exp Physiol 2026 0