protein

FERROPORTIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FERROPORTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

87Connections
0Hypotheses
0Analyses
50Outgoing
26Incoming

Summary

FERROPORTIN is a protein involved in neurodegeneration research. Key relationships include: regulates, transports, expressed in. Associated with Alzheimer, Cancer, Neurodegeneration. Connected to 31 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolFERROPORTIN
Chromosome2q32.2
FunctionFerroportin serves as the cellular iron export channel
Subcellular LocalizationPlasma membrane, Endosomes
Molecular Weight70 kDa
Amino Acids571 aa
PathwaysAlpha-Synuclein, Ferroptosis
UniProt ID[Q9NP59](https://www.uniprot.org/uniprot/Q9NP59)
GeneCardsFERROPORTIN
Human Protein AtlasFERROPORTIN
Associated Diseasesneurodegeneration
InteractionsDJ-1, AND, HEPCIDIN, TRANSFERRIN
KG Connections80 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Ferroportin (SLC40A1)

protein · 909 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

deferiprone-neurodegeneration

therapeutic · 4392 words

Ferroptosis in Alzheimer's Disease

mechanism · 4194 words

metal-ion-synuclein-mitochondria-axis-parkinsons

general · 4097 words

Metal Homeostasis Dysfunction Comparison Across Neurodegenerative Diseases

mechanism · 3711 words

Pathway Diagram

graph TD
    FERROPORTIN["<b>FERROPORTIN</b>"]
    Cancer{"Cancer"}
    FERROPORTIN -->|"regulates"| Cancer
    Tumor{"Tumor"}
    FERROPORTIN -->|"regulates"| Tumor
    Alzheimer{"Alzheimer"}
    FERROPORTIN -->|"regulates"| Alzheimer
    Parkinson{"Parkinson"}
    FERROPORTIN -->|"regulates"| Parkinson
    Neurodegeneration{"Neurodegeneration"}
    FERROPORTIN -->|"regulates"| Neurodegeneration
    TFR1["TFR1"]
    FERROPORTIN -->|"transports"| TFR1
    DMT1["DMT1"]
    FERROPORTIN -->|"transports"| DMT1
    CANCER["CANCER"]
    FERROPORTIN -->|"regulates"| CANCER
    JUN["JUN"]
    FERROPORTIN -->|"regulates"| JUN
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    FERROPORTIN -->|"regulates"| NEURODEGENERATIVE_DISEASES
    ALZHEIMER["ALZHEIMER"]
    FERROPORTIN -->|"regulates"| ALZHEIMER
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    FERROPORTIN -->|"regulates"| PARKINSON_S_DISEASE
    TFR1 -->|"regulates"| FERROPORTIN
    n_6_OHDA["6-OHDA"]
    n_6_OHDA -->|"regulates"| FERROPORTIN
    TFR1 -->|"transports"| FERROPORTIN
    AND["AND"]
    AND -->|"transports"| FERROPORTIN
    DMT1 -->|"transports"| FERROPORTIN
    ALZHEIMER -->|"regulates"| FERROPORTIN
    AND -->|"regulates"| FERROPORTIN
    NEURODEGENERATIVE_DISEASES -->|"regulates"| FERROPORTIN
    JUN -->|"regulates"| FERROPORTIN
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"regulates"| FERROPORTIN
    AND -->|"activates"| FERROPORTIN
    DJ_1["DJ-1"]
    DJ_1 -->|"activates"| FERROPORTIN
    style FERROPORTIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (58)

TargetRelationTypeStr
IRON METABOLISMinvolved_inentity0.90
Iron Metabolismregulatesprocess0.80
Cancerregulatesdisease0.65
Tumorregulatesdisease0.65
Alzheimerregulatesdisease0.65

Incoming (29)

SourceRelationTypeStr
HEPCIDINregulatesentity0.95
TFR1regulatesgene0.60
TFR1transportsgene0.60
DMT1transportsgene0.60
JUNregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found