Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FERROPORTIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FERROPORTIN is a protein involved in neurodegeneration research. Key relationships include: regulates, transports, expressed in. Associated with Alzheimer, Cancer, Neurodegeneration. Connected to 31 entities in the SciDEX knowledge graph.
| Gene Symbol | FERROPORTIN |
| Chromosome | 2q32.2 |
| Function | Ferroportin serves as the cellular iron export channel |
| Subcellular Localization | Plasma membrane, Endosomes |
| Molecular Weight | 70 kDa |
| Amino Acids | 571 aa |
| Pathways | Alpha-Synuclein, Ferroptosis |
| UniProt ID | [Q9NP59](https://www.uniprot.org/uniprot/Q9NP59) |
| GeneCards | FERROPORTIN |
| Human Protein Atlas | FERROPORTIN |
| Associated Diseases | neurodegeneration |
| Interactions | DJ-1, AND, HEPCIDIN, TRANSFERRIN |
| KG Connections | 80 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
FERROPORTIN["<b>FERROPORTIN</b>"]
Cancer{"Cancer"}
FERROPORTIN -->|"regulates"| Cancer
Tumor{"Tumor"}
FERROPORTIN -->|"regulates"| Tumor
Alzheimer{"Alzheimer"}
FERROPORTIN -->|"regulates"| Alzheimer
Parkinson{"Parkinson"}
FERROPORTIN -->|"regulates"| Parkinson
Neurodegeneration{"Neurodegeneration"}
FERROPORTIN -->|"regulates"| Neurodegeneration
TFR1["TFR1"]
FERROPORTIN -->|"transports"| TFR1
DMT1["DMT1"]
FERROPORTIN -->|"transports"| DMT1
CANCER["CANCER"]
FERROPORTIN -->|"regulates"| CANCER
JUN["JUN"]
FERROPORTIN -->|"regulates"| JUN
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
FERROPORTIN -->|"regulates"| NEURODEGENERATIVE_DISEASES
ALZHEIMER["ALZHEIMER"]
FERROPORTIN -->|"regulates"| ALZHEIMER
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
FERROPORTIN -->|"regulates"| PARKINSON_S_DISEASE
TFR1 -->|"regulates"| FERROPORTIN
n_6_OHDA["6-OHDA"]
n_6_OHDA -->|"regulates"| FERROPORTIN
TFR1 -->|"transports"| FERROPORTIN
AND["AND"]
AND -->|"transports"| FERROPORTIN
DMT1 -->|"transports"| FERROPORTIN
ALZHEIMER -->|"regulates"| FERROPORTIN
AND -->|"regulates"| FERROPORTIN
NEURODEGENERATIVE_DISEASES -->|"regulates"| FERROPORTIN
JUN -->|"regulates"| FERROPORTIN
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
ALPHA_SYNUCLEIN -->|"regulates"| FERROPORTIN
AND -->|"activates"| FERROPORTIN
DJ_1["DJ-1"]
DJ_1 -->|"activates"| FERROPORTIN
style FERROPORTIN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| IRON METABOLISM | involved_in | entity | 0.90 |
| Iron Metabolism | regulates | process | 0.80 |
| Cancer | regulates | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| TFR1 | transports | gene | 0.60 |
| DMT1 | transports | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| TFR1 | associated_with | entity | 0.60 |
| TFR1 | regulates | gene | 0.60 |
| DMT1 | associated_with | gene | 0.60 |
| MAP2 | regulates | gene | 0.60 |
| Ferritin | regulates | protein | 0.60 |
| Transferrin | transports | protein | 0.60 |
| Hemoglobin | regulates | protein | 0.60 |
| Transferrin | regulates | protein | 0.60 |
| Rb | regulates | protein | 0.60 |
| APOE | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| NEURODEGENERATION | regulates | gene | 0.60 |
| DJ-1 | activates | gene | 0.60 |
| ALPHA-SYNUCLEIN | regulates | gene | 0.60 |
| Alpha-Synuclein | regulates | pathway | 0.60 |
| AND | transports | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| 6-OHDA | regulates | gene | 0.60 |
| Macrophage | associated_with | cell_type | 0.60 |
| Neuron | regulates | cell_type | 0.60 |
| CYTOKINES | regulates | gene | 0.60 |
| HIF | regulates | gene | 0.60 |
| FERROPTOSIS | regulates | gene | 0.60 |
| Ferroptosis | regulates | pathway | 0.60 |
| Macrophage | transports | cell_type | 0.60 |
| Hepatocyte | transports | cell_type | 0.60 |
| ROS | regulates | gene | 0.60 |
| Aβ | regulates | protein | 0.60 |
| Cytokine | regulates | protein | 0.60 |
| Macrophage | expressed_in | cell_type | 0.55 |
| Substantia Nigra | expressed_in | brain_region | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| MACROPHAGES | associated_with | concept | 0.50 |
| HEPATOCYTES | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HEPCIDIN | regulates | entity | 0.95 |
| TFR1 | regulates | gene | 0.60 |
| TFR1 | transports | gene | 0.60 |
| DMT1 | transports | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| DMT1 | associated_with | entity | 0.60 |
| GPX4 | regulates | gene | 0.60 |
| APOE | regulates | gene | 0.60 |
| NRF2 | regulates | gene | 0.60 |
| NCOA4 | regulates | gene | 0.60 |
| 6-OHDA | regulates | gene | 0.60 |
| ALZHEIMER | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| ALPHA-SYNUCLEIN | regulates | gene | 0.60 |
| DJ-1 | activates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| NEURODEGENERATION | regulates | gene | 0.60 |
| ROS | regulates | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| CYTOKINES | regulates | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| TFR1 | associated_with | gene | 0.50 |
| MAP2 | regulates | gene | 0.50 |
| TRANSFERRIN | associated_with | protein | 0.50 |
| TRANSFERRIN | interacts_with | protein | 0.50 |
| TRANSFERRIN | regulates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||