concept

IRON METABOLISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRON METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

10Outgoing

26Incoming

0Experiments

0Debates

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Pathway Diagram

graph TD
    IRON_METABOLISM["IRON METABOLISM"]
    IRON_METABOLISM -->|"modulates"| Ferroptosis_Sensitivity["Ferroptosis Sensitivity"]
    IRON_METABOLISM -->|"involved_in"| Cancer["Cancer"]
    IRON_METABOLISM -->|"involved_in"| Ferroptosis["Ferroptosis"]
    IRON_METABOLISM -->|"involved_in"| Bovine_Mastitis["Bovine Mastitis"]
    IRON_METABOLISM -->|"regulates"| ferroptosis["ferroptosis"]
    IRON_METABOLISM -->|"regulates"| substantia_nigra_hyperechogeni["substantia nigra hyperechogenicity"]
    Mitochondria["Mitochondria"] -->|"involved_in"| IRON_METABOLISM
    TFR1["TFR1"] -->|"regulates"| IRON_METABOLISM
    TRANSFERRIN["TRANSFERRIN"] -->|"involved_in"| IRON_METABOLISM
    TRANSFERRIN_RECEPTOR_1["TRANSFERRIN RECEPTOR 1"] -->|"involved_in"| IRON_METABOLISM
    HEPCIDIN["HEPCIDIN"] -->|"regulates"| IRON_METABOLISM
    Hepcidin_Ferroportin_Axis["Hepcidin-Ferroportin Axis"] -->|"regulates"| IRON_METABOLISM
    FERROPORTIN["FERROPORTIN"] -->|"involved_in"| IRON_METABOLISM
    TRANSFERRIN_RECEPTOR_2["TRANSFERRIN RECEPTOR 2"] -->|"involved_in"| IRON_METABOLISM

Outgoing (10)

Target	Relation	Type	Str
Ferroptosis Sensitivity	modulates	phenotype	0.90
Oxidative Stress	associated_with	process	0.90
HEMOGLOBIN	associated_with	protein	0.88
Cancer	involved_in	disease	0.85
Ferroptosis	involved_in	process	0.85
Bovine Mastitis	involved_in	disease	0.80
Staphylococcus aureus infection	involved_in	disease	0.80
Glucose Metabolism	interacts_with	process	0.75
ferroptosis	regulates	process	0.70
substantia nigra hyperechogenicity	regulates	biomarker_for	0.70

Incoming (26)

Source	Relation	Type	Str
HBB	involved_in	protein	0.95
HAMP	regulates	protein	0.95
Mitochondria	involved_in	cell_type	0.95
TRANSFERRIN	involved_in	entity	0.95
TRANSFERRIN RECEPTOR 1	involved_in	entity	0.95
HEPCIDIN	regulates	entity	0.95
HEPATOCYTE	involved_in	entity	0.90
FERROPORTIN	involved_in	entity	0.90
TRANSFERRIN RECEPTOR 2	involved_in	entity	0.90
MACROPHAGE	involved_in	entity	0.90
Hepcidin-Ferroportin Axis	regulates	pathway	0.90
DMT1	involved_in	entity	0.90
FERRITIN	involved_in	entity	0.90
TFRC	involved_in	gene	0.90
TFRC	regulates	gene	0.90
TP53	regulates	gene	0.88
Ferritin	involved_in	protein	0.88
NCOA4	regulates	gene	0.85
NCOA4	involved_in	gene	0.85
Ferritin Degradation	involved_in	process	0.85
HEMOCHROMATOSIS PROTEIN	involved_in	entity	0.85
NFE2L2	regulates	gene	0.85
LCN2	regulates	protein	0.80
FERROPORTIN	regulates	protein	0.80
MAPT	involved_in	gene	0.70
ferroptosis	regulates	process	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity