concept

HEPATOCYTES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEPATOCYTES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

186Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	HEPATOCYTES
Key Genes/Proteins	FOXO1, JAK2, BRD4
Related Diseases	INFLAMMATION, OXIDATIVE STRESS, FATTY ACID OXIDATION, FIBROSIS
Related Pathways	NLRP3 INFLAMMASOME

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HEPATOCYTES["HEPATOCYTES"]
    HEPATOCYTES -->|"activates"| INFLAMMATION["INFLAMMATION"]
    HEPATOCYTES -->|"activates"| ISCHEMIA["ISCHEMIA"]
    HEPATOCYTES -->|"activates"| NAFLD["NAFLD"]
    HEPATOCYTES -->|"activates"| KEAP1["KEAP1"]
    HEPATOCYTES -->|"activates"| P62["P62"]
    HEPATOCYTES -->|"transports"| MACROPHAGES["MACROPHAGES"]
    HEPATOCYTES -->|"activates"| TNF["TNF"]
    HEPATOCYTES -->|"activates"| OBESITY["OBESITY"]
    FOXO1["FOXO1"] -->|"expressed in"| HEPATOCYTES
    IL30["IL30"] -->|"expressed in"| HEPATOCYTES
    LDLR["LDLR"] -->|"expressed in"| HEPATOCYTES
    Metformin["Metformin"] -->|"expressed in"| HEPATOCYTES
    FIBROSIS["FIBROSIS"] -->|"activates"| HEPATOCYTES
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| HEPATOCYTES
    APOPTOSIS["APOPTOSIS"] -->|"causes"| HEPATOCYTES

Outgoing (64)

Target	Relation	Type	Str
FOXO1	treats	gene	0.65
INFLAMMATION	interacts_with	phenotype	0.65
JAK2	causes	gene	0.65
METFORMIN	treats	drug	0.65
NLRP3 INFLAMMASOME	protects_against	pathway	0.65
NLRP3 INFLAMMASOME	activates	pathway	0.65
NLRP3 INFLAMMASOME	inhibits	pathway	0.65
NLRP3 INFLAMMASOME	targets	pathway	0.65
JAK2	phosphorylates	gene	0.65
BRD4	activates	gene	0.65
BRD4	targets	gene	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
FATTY ACID OXIDATION	inhibits	phenotype	0.65
INFLAMMATION	activates	process	0.50
ISCHEMIA	activates	disease	0.50
NAFLD	activates	disease	0.50
KEAP1	activates	gene	0.50
P62	activates	gene	0.50
LIPID RAFT	associated_with	organelle	0.50
DENDRITIC CELLS	interacts_with	concept	0.50
NASH	associated_with	disease	0.45
MACROPHAGES	transports	cell_type	0.35
TNF	activates	gene	0.35
OBESITY	activates	disease	0.35
ROS	implicated_in	protein	0.35
NK CELLS	implicated_in	cell_type	0.35
MACROPHAGES	implicated_in	cell_type	0.35
MONOCYTES	implicated_in	cell_type	0.35
INFLAMMATION	associated_with	process	0.35
METFORMIN	interacts_with	drug	0.35
METASTASIS	activates	process	0.35
ORGANOIDS	interacts_with	cell_type	0.35
TNF	implicated_in	gene	0.35
MACROPHAGES	causes	cell_type	0.35
INFLAMMATION	inhibits	process	0.35
TLR4	activates	gene	0.35
METFORMIN	therapeutic_target	drug	0.35
SQSTM1	activates	gene	0.35
NRF2	activates	gene	0.35
PI3K	interacts_with	gene	0.35
LIPID METABOLISM	regulates	process	0.35
INFLAMMATION	regulates	process	0.35
MITOPHAGY	protects_against	process	0.35
OPTN	protects_against	gene	0.35
IL-18	implicated_in	gene	0.35
MTOR SIGNALING	activates	process	0.35
MAPK	activates	gene	0.35
MAPK SIGNALING	inhibits	process	0.35
MITOPHAGY	activates	process	0.35
ROS	activates	protein	0.35

Incoming (122)

Source	Relation	Type	Str
APAP	causes_damage_to	compound	0.90
FIBROSIS	activates	disease	0.65
OPTN	exacerbates	gene	0.65
BRD4	inhibits	gene	0.65
BRD4	treats	gene	0.65
UBIQUITIN	regulates	protein	0.65
NLRP3 INFLAMMASOME	causes	pathway	0.65
NEURON	targets	cell_type	0.60
FERROPTOSIS	activates	process	0.50
APOPTOSIS	causes	process	0.50
AGING	interacts_with	process	0.50
SEMAGLUTIDE	associated_with	drug	0.50
TFR1	associated_with	gene	0.50
DMT1	associated_with	gene	0.50
TRANSFERRIN	associated_with	protein	0.50
FERROPORTIN	associated_with	protein	0.50
MACROPHAGES	associated_with	concept	0.50
HEPCIDIN	activates	protein	0.50
TGF-Β1	inhibits	protein	0.50
CCL4	activates	gene	0.50
TGF-Β1	activates	protein	0.50
ISCHEMIA	activates	disease	0.50
ALOX12	activates	concept	0.50
inflammation	activates	pathway	0.50
Hepatitis	activates	disease	0.50
OBESITY	activates	disease	0.50
Infection	activates	disease	0.50
Fatty Liver	activates	disease	0.50
CYTOKINES	interacts_with	concept	0.50
MACROPHAGES	interacts_with	concept	0.50
ENDOTHELIAL	interacts_with	concept	0.50
Reactive Oxygen Species	interacts_with	process	0.50
MONOCYTES	interacts_with	concept	0.50
CELL DEATH	activates	concept	0.50
inflammation	associated_with	pathway	0.50
CELL DEATH	associated_with	concept	0.50
METFORMIN	activates	concept	0.50
RAB27A	activates	protein	0.50
ENDOTHELIAL	associated_with	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
CARCINOMA	associated_with	disease	0.50
TUMOR	associated_with	disease	0.50
inflammation	inhibits	pathway	0.50
TLR4	activates	gene	0.50
MYD88	activates	gene	0.50
TLR9	activates	gene	0.50
Toll-Like Receptor	activates	pathway	0.50
METFORMIN	associated_with	concept	0.50
SQSTM1	activates	gene	0.50
KEAP1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HEPATOCYTES

Understanding Entity Pages

Wiki Pages (20)

NPM1 Gene

APOC4 — Apolipoprotein C-IV

Niemann-Pick Disease Type C (NPC)

KARS1

RPL30 — Ribosomal Protein L30 in Neurodegeneration

COX20 Gene - Cytochrome c Oxidase Assembly Factor

CNTF Signaling Pathway in Neurodegeneration

Alpha-Synuclein ESCRT-III Inhibition Mechanism

Mitophagy Pathway in Neurodegeneration

Longevity and Rejuvenation Therapies Landscape

YME1L1 Gene

IL28B (Interleukin 28B)

GPT - Alanine Transaminase (ALT)

Alzheimer's Disease Synaptic Repair and Neuroprotection Companies

Receptor-Mediated Transcytosis (RMT)

FOXO4 — Forkhead Box O4

Liver-Brain Neurodegeneration Axis

ATP13A2 — ATPase Cation Transporting 13A2