protein

HEXBPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HEXBPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

Summary

Hexosaminidase B (Hex B) Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	HEXBPROTEIN
Protein Family	Glycoside hydrolase family 20
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	Lysosome
Molecular Weight	~110 kDa (homodimer)
Amino Acids	556 aa
UniProt ID	P07604
GeneCards	HEXBPROTEIN
Human Protein Atlas	HEXBPROTEIN
infobox	[@shyer2003]
Hexosaminidase B (Hex B)	[@matsuoka2006]
Gene	HEXB
PDB Structures	2YJJ, 5G0M
Asialo-GM2	Lactosylceramide + GalNAc
Globoside	Lactosylceramide
Associated Diseases	ALS, Sandhoff Disease, disease, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	MTOR, TSC2, Rb, SALL1, TMEM119, LC3
KG Connections	98 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HEXBPROTEIN — AlphaFold P07604 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Hexosaminidase B (Hex B) Protein

protein · 810 words

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Pathway Diagram

graph TD
    HEXBPROTEIN["HEXBPROTEIN"]
    neurodegeneration["neurodegeneration"]
    HEXBPROTEIN -->|"implicated_in"| neurodegeneration
    style HEXBPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found