gene

HGSNAT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HGSNAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

9Outgoing

5Incoming

0Experiments

0Debates

Summary

Heparan-Alpha-Glucosaminide N-Acetyltransferase - a lysosomal enzyme involved in heparan sulfate catabolism

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🧬 Gene Info

Gene Symbol	HGSNAT
Full Name	Heparan-Alpha-Glucosaminide N-Acetyltransferase
Aliases	Page for HGSNAT Protein
Protein Type	Enzyme
Function	is a transmembrane enzyme located in the lysosomal membrane that catalyzes the N-acetylation of the terminal alpha-glucosamine residue of heparan sulfate.
Molecular Weight	72 kDa
Amino Acids	603 aa
Ensembl ID	ENSG00000145192
GeneCards	HGSNAT
Human Protein Atlas	HGSNAT
Associated Diseases	Als, Anxiety, Inflammation, Neurodegeneration, Neuroinflammation
KG Connections	14 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HGSNAT Gene

gene · 1752 words

→

HGSNAT Protein - Heparan-Alpha-Glucosaminide N-Acetyltransferase

protein · 619 words

→

Pathway Diagram

graph TD
    HGSNAT["HGSNAT"]
    Als{"Als"}
    HGSNAT -->|"causes"| Als
    Neuroinflammation{"Neuroinflammation"}
    HGSNAT -->|"causes"| Neuroinflammation
    Inflammation{"Inflammation"}
    HGSNAT -->|"causes"| Inflammation
    Anxiety{"Anxiety"}
    HGSNAT -->|"causes"| Anxiety
    Neurodegeneration{"Neurodegeneration"}
    HGSNAT -->|"causes"| Neurodegeneration
    MITOCHONDRIAL_DYSFUNCTION(["MITOCHONDRIAL DYSFUNCTION"])
    HGSNAT -->|"causes"| MITOCHONDRIAL_DYSFUNCTION
    NEURODEGENERATION(["NEURODEGENERATION"])
    NEURODEGENERATION -->|"causes"| HGSNAT
    TAU(["TAU"])
    TAU -->|"causes"| HGSNAT
    ACETYL_COA(["ACETYL-COA"])
    ACETYL_COA -->|"causes"| HGSNAT
    ANXIETY(["ANXIETY"])
    ANXIETY -->|"causes"| HGSNAT
    style HGSNAT fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (9)

Target	Relation	Type	Str
Neurodegeneration	causes	disease	0.65
Als	causes	disease	0.65
Neuroinflammation	causes	disease	0.65
Inflammation	causes	disease	0.65
Anxiety	causes	disease	0.65
MITOCHONDRIA	causes	gene	0.60
NEUROINFLAMMATION	causes	gene	0.60
MICROGLIA	causes	gene	0.60
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.60

Incoming (5)

Source	Relation	Type	Str
NEURODEGENERATION	causes	gene	0.60
ACETYL-COA	causes	gene	0.60
ANXIETY	causes	gene	0.60
AMYLOID	causes	gene	0.60
TAU	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HGSNAT in their description or question text

No additional research found