Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ACETYL-COA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ACETYL-COA is a concept in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 391 entities in the SciDEX knowledge graph.
| Name | ACETYL-COA |
| Key Genes/Proteins | STAT3, AUTOPHAGY, CANCER, MICROGLIA, ATP |
| Related Diseases | Cancer, Tumor, Als, Inflammation, Obesity |
| Related Pathways | Autophagy |
Knowledge base pages for this entity
graph TD
ACETYL_COA["ACETYL-COA"]
ACETYL_COA -->|"activates"| STAT3["STAT3"]
ACETYL_COA -->|"activates"| histone_acetylation["histone acetylation"]
ACETYL_COA -->|"activates"| Tumor["Tumor"]
ACETYL_COA -->|"activates"| Ms["Ms"]
ACETYL_COA -->|"activates"| Als["Als"]
ACETYL_COA -->|"inhibits"| Cardiovascular["Cardiovascular"]
ACETYL_COA -->|"inhibits"| Atherosclerosis["Atherosclerosis"]
ACETYL_COA -->|"interacts"| Alzheimer["Alzheimer"]
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ACETYL_COA
AMPK["AMPK"] -->|"activates"| ACETYL_COA
BNIP3["BNIP3"] -->|"activates"| ACETYL_COA
BCL2["BCL2"] -->|"activates"| ACETYL_COA
GLI1["GLI1"] -->|"activates"| ACETYL_COA
ATG["ATG"] -->|"activates"| ACETYL_COA
BECN1["BECN1"] -->|"activates"| ACETYL_COA
ATG7["ATG7"] -->|"activates"| ACETYL_COA
PIK3C3["PIK3C3"] -->|"activates"| ACETYL_COA
MITOPHAGY["MITOPHAGY"] -->|"activates"| ACETYL_COA| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | inhibits | disease | 0.95 |
| Cancer | activates | disease | 0.95 |
| STAT3 | activates | gene | 0.90 |
| Tumor | activates | disease | 0.85 |
| Als | activates | disease | 0.85 |
| Tumor | inhibits | disease | 0.85 |
| Inflammation | activates | disease | 0.85 |
| Obesity | activates | disease | 0.85 |
| Autophagy | activates | pathway | 0.80 |
| AUTOPHAGY | activates | gene | 0.80 |
| CANCER | activates | gene | 0.80 |
| MICROGLIA | activates | gene | 0.80 |
| ATP | activates | gene | 0.80 |
| Als | regulates | disease | 0.75 |
| Lung Cancer | inhibits | disease | 0.75 |
| Tumor | therapeutic_target | disease | 0.75 |
| Als | therapeutic_target | disease | 0.75 |
| Mitophagy | activates | pathway | 0.70 |
| Lipid Metabolism | associated_with | pathway | 0.70 |
| Epigenetic | regulates | pathway | 0.70 |
| Glycolysis | activates | pathway | 0.70 |
| AUTOPHAGY | regulates | gene | 0.70 |
| Autophagy | regulates | pathway | 0.70 |
| AMPK | activates | gene | 0.70 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.70 |
| MITOCHONDRIA | activates | gene | 0.70 |
| Oxidative Phosphorylation | activates | pathway | 0.70 |
| CANCER | inhibits | gene | 0.70 |
| Mtor | inhibits | pathway | 0.70 |
| GENES | activates | gene | 0.70 |
| Angiogenesis | inhibits | pathway | 0.70 |
| Invasion | inhibits | pathway | 0.70 |
| Ms | activates | disease | 0.65 |
| Cardiovascular | inhibits | disease | 0.65 |
| Atherosclerosis | inhibits | disease | 0.65 |
| Alzheimer | interacts_with | disease | 0.65 |
| Aging | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Huntington | interacts_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MITOPHAGY | activates | gene | 0.70 |
| CANCER | inhibits | gene | 0.70 |
| SIRT1 | activates | gene | 0.70 |
| AUTOPHAGY | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| BNIP3 | activates | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| GLI1 | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| ATG7 | activates | gene | 0.60 |
| PIK3C3 | activates | gene | 0.60 |
| YWHAG | activates | gene | 0.60 |
| RICTOR | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| ENDOG | activates | gene | 0.60 |
| MTORC1 | activates | gene | 0.60 |
| BIP | activates | gene | 0.60 |
| IRE1A | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| TSC2 | activates | gene | 0.60 |
| EIF2AK3 | activates | gene | 0.60 |
| GSK3B | activates | gene | 0.60 |
| ERN1 | activates | gene | 0.60 |
| HSPA5 | activates | gene | 0.60 |
| APOE | inhibits | gene | 0.60 |
| LDLR | inhibits | gene | 0.60 |
| AGING | interacts_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | interacts_with | gene | 0.60 |
| SIRT3 | regulates | gene | 0.60 |
| PGC1A | interacts_with | gene | 0.60 |
| ATP5F1 | interacts_with | gene | 0.60 |
| P53 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| HUNTINGTON'S DISEASE | interacts_with | gene | 0.60 |
| CLOCK | interacts_with | gene | 0.60 |
| SDHB | interacts_with | gene | 0.60 |
| PPARG | interacts_with | gene | 0.60 |
| PARK7 | interacts_with | gene | 0.60 |
| AMPK | interacts_with | gene | 0.60 |
| BACE1 | interacts_with | gene | 0.60 |
| APOE3 | regulates | gene | 0.60 |
| MIRNAS | contributes_to | gene | 0.60 |
| APOE4 | regulates | gene | 0.60 |
| ASTROCYTES | regulates | gene | 0.60 |
| APOE | contributes_to | gene | 0.60 |
| MICRORNAS | contributes_to | gene | 0.60 |
| PDK1 | associated_with | gene | 0.60 |
| VHL | inhibits | gene | 0.60 |
| COMPLEMENT | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||