protein

IGF1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

Insulin Like Growth Factor 1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	IGF1PROTEIN
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	</th><td>Extracellular, Cell Surface</td></tr>
GeneCards	IGF1PROTEIN
Human Protein Atlas	IGF1PROTEIN
B Domain (residues 1-25)	Core binding region
C Domain (residues 26-33)	Connecting peptide (cleaved in mature form)
A Domain (residues 42-62)	Receptor binding region
D Domain (residues 63-70)	C-terminal extension
Reduced CSF IGF1	Levels are decreased in AD patients, correlating with cognitive decline
Impaired Signaling	Post-receptor signaling defects reduce downstream neuroprotective effects
Amyloid Interaction	Aβ oligomers interfere with IGF1 receptor function
[Tau](/proteins/tau) Pathology	Hyperphosphorylated tau disrupts IGF1 signaling cascades
Therapeutic Potential	IGF1 administration improves cognitive function in AD mouse models
Dopaminergic Protection	IGF1 protects substantia nigra neurons from 6-OHDA and MPTP toxicity
Associated Diseases	ALS, Alzheimer, Ms
Known Drugs/Compounds	rapamycin
Interactions	ACHE, AGING, AKT, AKT1, ALZHEIMER, AMPK
KG Connections	528 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Insulin-Like Growth Factor 1 Protein

protein · 916 words

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Pathway Diagram

graph TD
    IGF1PROTEIN["IGF1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    IGF1PROTEIN -->|"implicated_in"| neurodegeneration
    style IGF1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IGF1PROTEIN in their description or question text

No additional research found