| Gene Symbol | IGF1PROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | </th><td>Extracellular, Cell Surface</td></tr> |
| GeneCards | IGF1PROTEIN |
| Human Protein Atlas | IGF1PROTEIN |
| B Domain (residues 1-25) | Core binding region |
| C Domain (residues 26-33) | Connecting peptide (cleaved in mature form) |
| A Domain (residues 42-62) | Receptor binding region |
| D Domain (residues 63-70) | C-terminal extension |
| Reduced CSF IGF1 | Levels are decreased in AD patients, correlating with cognitive decline |
| Impaired Signaling | Post-receptor signaling defects reduce downstream neuroprotective effects |
| Amyloid Interaction | Aβ oligomers interfere with IGF1 receptor function |
| [Tau](/proteins/tau) Pathology | Hyperphosphorylated tau disrupts IGF1 signaling cascades |
| Therapeutic Potential | IGF1 administration improves cognitive function in AD mouse models |
| Dopaminergic Protection | IGF1 protects substantia nigra neurons from 6-OHDA and MPTP toxicity |
| Associated Diseases | ALS, Alzheimer, Ms |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACHE, AGING, AKT, AKT1, ALZHEIMER, AMPK |
| KG Connections | 528 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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