concept

IRF4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

37Outgoing

7Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	IRF4
Key Genes/Proteins	NF-κB, MYC
Related Diseases	Multiple Myeloma
Related Pathways	Autoregulatory Circuit

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IRF4["IRF4"]
    IRF4 -->|"involved_in"| Lymphocyte_Activation["Lymphocyte Activation"]
    IRF4 -->|"involved_in"| Immunoglobulin_Secretion["Immunoglobulin Secretion"]
    IRF4 -->|"involved_in"| Plasma_Cell_Generation["Plasma Cell Generation"]
    IRF4 -->|"expressed in"| Myeloma_Cell_Lines["Myeloma Cell Lines"]
    IRF4 -->|"upregulates"| MYC["MYC"]
    IRF4 -->|"component_of"| Autoregulatory_Circuit["Autoregulatory Circuit"]
    IRF4 -->|"activates"| Immunoglobulin_Secreting_Plasm["Immunoglobulin-Secreting Plasma Cells"]
    NF__B["NF-kappaB"] -->|"activates"| IRF4
    MYC -->|"upregulates"| IRF4
    CANCER["CANCER"] -->|"activates"| IRF4
    JUN["JUN"] -->|"activates"| IRF4

Outgoing (37)

Target	Relation	Type	Str
Multiple Myeloma	associated_with	disease	0.98
Lymphocyte Activation	involved_in	process	0.95
Immunoglobulin Secretion	involved_in	process	0.95
Plasma Cell Generation	involved_in	process	0.95
Multiple Myeloma	therapeutic_target	disease	0.95
Multiple Myeloma	implicated_in	disease	0.95
Myeloma Cell Lines	expressed_in	cell_type	0.93
MYC	upregulates	gene	0.92
Autoregulatory Circuit	component_of	mechanism	0.90
Lymphocyte Activation	regulates	process	0.90
Immunoglobulin-Secreting Plasma Cells	activates	cell_type	0.90
Plasma Cell	regulates	cell_type	0.90
plasma cell	expressed_in	cell_type	0.90
Gene Expression Profiling	biomarker_for	biomarker	0.88
Immunoglobulin Secretion	regulates	process	0.85
Multiple Myeloma	contributes_to	disease	0.85
gene expression	regulates	process	0.85
multiple myeloma	required_for	disease	0.80
Cancer	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Addiction	associated_with	disease	0.65
GENES	activates	gene	0.60
MYC	activates	gene	0.60
RNA	inhibits	gene	0.60
JUN	activates	gene	0.60
AND	activates	gene	0.60
CANCER	activates	gene	0.60
Immune Response	activates	pathway	0.60
MYC	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
B Cell	therapeutic_target	cell_type	0.60
Interferon	activates	protein	0.60
Tau	therapeutic_target	protein	0.60
Fus	activates	protein	0.60
MYC	targets	gene	0.60
MYC	associated_with	gene	0.60
B Cell	expressed_in	cell_type	0.55

Incoming (7)

Source	Relation	Type	Str
NF-κB	activates	protein	0.95
MYC	upregulates	gene	0.92
MYC	binds	protein	0.85
CANCER	activates	gene	0.60
JUN	activates	gene	0.60
JUN	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IRF4

Understanding Entity Pages

Wiki Pages (7)

SPI1 Gene - PU.1

PP2B Protein (Calcineurin)

PRDM1 Gene

Microglial Polarization

IL23A Gene