Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Innate Immune Activation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Innate Immune Activation |
| Key Genes/Proteins | HMGB1 |
| Related Diseases | Alzheimer Disease, Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia |
| Related Pathways | Mitoxyperiosis |
Knowledge base pages for this entity
graph TD
Innate_Immune_Activation["Innate Immune Activation"] -->|"causes"| Mitoxyperiosis["Mitoxyperiosis"]
style Mitoxyperiosis fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Innate_Immune_Activation["Innate Immune Activation"] -->|"contributes to"| Alzheimer_Disease["Alzheimer Disease"]
style Alzheimer_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Innate_Immune_Activation["Innate Immune Activation"] -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Innate_Immune_Activation["Innate Immune Activation"] -->|"contributes to"| Parkinson_s_Disease["Parkinson's Disease"]
style Parkinson_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Innate_Immune_Activation["Innate Immune Activation"] -->|"contributes to"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
style Amyotrophic_Lateral_Sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Innate_Immune_Activation["Innate Immune Activation"] -->|"contributes to"| Frontotemporal_Dementia["Frontotemporal Dementia"]
style Frontotemporal_Dementia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Innate_Immune_Activation["Innate Immune Activation"] -->|"contributes to"| ALS["ALS"]
style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Pattern_Recognition_Receptors["Pattern Recognition Receptors"] -->|"activates"| Innate_Immune_Activation["Innate Immune Activation"]
style Pattern_Recognition_Receptors fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Pattern_Recognition_Receptor["Pattern Recognition Receptor"] -->|"activates"| Innate_Immune_Activation["Innate Immune Activation"]
style Pattern_Recognition_Receptor fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
SNCA["SNCA"] -->|"activates"| Innate_Immune_Activation["Innate Immune Activation"]
style SNCA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Mitochondrial_DNA_Release["Mitochondrial DNA Release"] -->|"contributes to"| Innate_Immune_Activation["Innate Immune Activation"]
style Mitochondrial_DNA_Release fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
STING1["STING1"] -->|"activates"| Innate_Immune_Activation["Innate Immune Activation"]
style STING1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
style Innate_Immune_Activation fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Mitoxyperiosis | causes | mechanism | 0.95 |
| Alzheimer Disease | contributes_to | disease | 0.90 |
| Alzheimer's Disease | contributes_to | disease | 0.90 |
| Parkinson's Disease | contributes_to | disease | 0.90 |
| Amyotrophic Lateral Sclerosis | contributes_to | disease | 0.90 |
| Frontotemporal Dementia | contributes_to | disease | 0.90 |
| Alzheimer'S Disease | contributes_to | disease | 0.90 |
| Parkinson'S Disease | contributes_to | disease | 0.90 |
| ALS | contributes_to | disease | 0.90 |
| Dementia | contributes_to | disease | 0.90 |
| Alzheimer'S Disease | associated_with | disease | 0.90 |
| Parkinson'S Disease | associated_with | disease | 0.90 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 0.90 |
| Frontotemporal Dementia | associated_with | disease | 0.90 |
| Synaptic Disbalance | causes | phenotype | 0.82 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Pattern Recognition Receptors | activates | receptor | 0.95 |
| Pattern Recognition Receptor | activates | receptor | 0.95 |
| HMGB1 | activates | protein | 0.95 |
| SNCA | activates | protein | 0.90 |
| Mitochondrial DNA Release | contributes_to | process | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||