JAG2

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Jagged 2 - critical Notch ligand in neurodevelopment, synaptic plasticity, and neurodegenerative disease pathways

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flowchart TD
    N0["JAG2"]
    N1["Als"]
    N0 -->|"expressed in"| N1
    N2["Neurodegeneration"]
    N0 -->|"associated with"| N2
    N3["ALS"]
    N0 -->|"expressed in"| N3
    N4["SPTLC1"]
    N0 -->|"associated with"| N4
    N5["KCNJ6"]
    N0 -->|"expressed in"| N5
    N6["STRAP"]
    N0 -->|"associated with"| N6
    N7["Ras"]
    N0 -->|"expressed in"| N7
    N8["NEURODEGENERATION"]
    N8 -->|"associated with"| N0
    N9["GENES"]
    N9 -->|"expressed in"| N0
    N5 -->|"expressed in"| N0
    N4 -->|"associated with"| N0
    N6 -->|"associated with"| N0
    N10["AND"]
    N10 -->|"associated with"| N0
    N11["RAS"]
    N11 -->|"expressed in"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 protein
    class N8 gene
    class N9 gene
    class N10 gene
    class N11 gene