gene 2,167 words KG: NOTCH2 2026-03-27
kind:genesection:genesstate:published
Contents

NOTCH2 — Notch Receptor 2

🧬 Gene Info
Gene SymbolNOTCH2
Full NameNotch Receptor 2
Chromosome1p11
Protein TypeReceptor
Functionencodes a highly conserved transmembrane protein that serves as a critical regulator of cell fate decisions, tissue homeostasis, and developmental processes throughout the nervous and vascular syst...
Primary ExpressionCerebral cortex, Hippocampus, Vascular smooth muscle
Molecular Weight265 kDa
PathwaysPathway: An Overview, NOTCH, Notch, Notch Signaling
UniProt IDQ12983
NCBI Gene ID4853
Ensembl IDENSG00000134250
OMIM600275
GeneCardsNOTCH2
Human Protein AtlasNOTCH2
Associated DiseasesDiabetes, Glioblastoma
InteractionsLRP1, DLL4, NFKBIE, CDKN2A, SMARCA4, GJA1
KG Connections212 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

See Also (15)

Packard Center for ALS Research
institution · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: regulates
CD44 - Cell Surface Glycoprotein
gene · KG edge: therapeutic_target
CD19 Gene
gene · KG edge: therapeutic_target
BRG1 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

NOTCH2 inhibits LRP1
NOTCH2 inhibits DLL4
NOTCH2 therapeutic_target EP300
NOTCH2 therapeutic_target CTNNB1
NOTCH2 therapeutic_target NEUROD1
NOTCH2 therapeutic_target MYC
NOTCH2 therapeutic_target VEGFA
NOTCH2 therapeutic_target ABCB1
NOTCH2 therapeutic_target FOXM1
NOTCH2 therapeutic_target LEF1