Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KCNA1 encodes Kv1.1, a voltage-gated potassium channel critical for neuronal excitability, repolarization, and synaptic transmission
| Gene Symbol | KCNA1 |
| Full Name | Potassium Voltage-Gated Channel Subfamily A Member 1 |
| Chromosome | 12p13.32 |
| Function | is a tetramer of four α-subunits, which can form homomeric (Kv1. |
| Subcellular Localization | In the central nervous system, Kv1.1 is strategically positioned: |
| UniProt ID | P09488 |
| NCBI Gene ID | 3736 |
| Ensembl ID | ENSG00000111245 |
| OMIM | 176260 |
| GeneCards | KCNA1 |
| Human Protein Atlas | KCNA1 |
| Protein Name | Kv1.1 (Potassium voltage-gated channel subfamily A member 1) |
| Region | Function |
| Axonal Initial Segment (AIS) | Regulates action potential initiation |
| Nodes of Ranvier | Ensures saltatory conduction |
| Associated Diseases | Als, Epilepsy |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNA1["KCNA1"]
Als{"Als"}
KCNA1 -->|"causes"| Als
Epilepsy{"Epilepsy"}
KCNA1 -->|"causes"| Epilepsy
FGF14["FGF14"]
KCNA1 -->|"causes"| FGF14
Neuron["Neuron"]
KCNA1 -->|"causes"| Neuron
Purkinje["Purkinje"]
KCNA1 -->|"causes"| Purkinje
Fibroblast["Fibroblast"]
KCNA1 -->|"causes"| Fibroblast
Fgf("Fgf")
KCNA1 -->|"causes"| Fgf
CACNA1A["CACNA1A"]
CACNA1A -->|"causes"| KCNA1
SLC1A3["SLC1A3"]
SLC1A3 -->|"causes"| KCNA1
EPILEPSY["EPILEPSY"]
EPILEPSY -->|"causes"| KCNA1
neurodegeneration["neurodegeneration"]
KCNA1 -->|"implicated_in"| neurodegenerationHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||