protein

SLC1A3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC1A3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

40Outgoing

15Incoming

Summary

SLC1A3 is a protein involved in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Alzheimer. Connected to 12 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	SLC1A3
Full Name	Solute Carrier Family 1 Member 3
Chromosome	5p13.2
Protein Type	Transporter
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	astrocytes and plays a critical role in maintaining extracellular glutamate homeostasis in the central nervous system by clearing glutamate from the s
Molecular Weight	59 kDa
Pathways	climbing fiber innervation, glutamate clearance, glutamate transport, synaptic wrapping
UniProt ID	P43003
NCBI Gene ID	6507
Ensembl ID	ENSG00000081189
OMIM	600116
GeneCards	SLC1A3
Human Protein Atlas	SLC1A3
Previous Names	EAAT1, GLAST
Associated Diseases	Als, Alzheimer's disease, auditory function, spinocerebellar ataxia
Known Drugs/Compounds	arundic acid
Interactions	APP, KCNJ10, ALZHEIMER, ALZHEIMER'S DISEASE, PHAGOCYTOSIS, ALS
KG Connections	55 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC1A3 — AlphaFold P43003 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC1A3["<b>SLC1A3</b>"]
    Alzheimer{"Alzheimer"}
    SLC1A3 -->|"activates"| Alzheimer
    ALZHEIMER(["ALZHEIMER"])
    SLC1A3 -->|"activates"| ALZHEIMER
    ALZHEIMER_S_DISEASE(["ALZHEIMER'S DISEASE"])
    SLC1A3 -->|"activates"| ALZHEIMER_S_DISEASE
    PHAGOCYTOSIS(["PHAGOCYTOSIS"])
    SLC1A3 -->|"activates"| PHAGOCYTOSIS
    APP(["APP"])
    SLC1A3 -->|"activates"| APP
    Phagocytosis["Phagocytosis"]
    SLC1A3 -->|"activates"| Phagocytosis
    NLRP3(["NLRP3"])
    NLRP3 -->|"activates"| SLC1A3
    APP_PS1(["APP/PS1"])
    APP_PS1 -->|"activates"| SLC1A3
    ASC(["ASC"])
    ASC -->|"activates"| SLC1A3
    arundic_acid["arundic acid"]
    arundic_acid -->|"activates"| SLC1A3
    style SLC1A3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (40)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
Huntington	activates	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	causes	disease	0.65
APP	activates	gene	0.60
synaptic wrapping	involved_in	process	0.60
glutamate transport	involved_in	process	0.60
Bergmann glia	expressed_in	cell_type	0.60
climbing fiber innervation	involved_in	process	0.60
auditory function	associated_with	phenotype	0.60
synaptic pathology	associated_with	process	0.60
spinocerebellar ataxia	implicated_in	disease	0.60
glutamate clearance	involved_in	process	0.60
excitotoxicity	protects_against	process	0.60
therapeutic_target	therapeutic_target	process	0.60
KCNJ10	activates	gene	0.60
KCNA1	causes	gene	0.60
FGF14	causes	gene	0.60
Purkinje	causes	cell_type	0.60
ALZHEIMER	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
Phagocytosis	activates	pathway	0.60
Epigenetic	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
EAAT4	co_expressed_with	protein	0.60
Alzheimer's disease	implicated_in	disease	0.60
Neuron	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
ALS	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
APP/PS1	activates	gene	0.60
Sod1	activates	protein	0.60
EPILEPSY	causes	gene	0.60
Neuron	causes	cell_type	0.60
Fibroblast	causes	cell_type	0.60
Fgf	causes	protein	0.60

Incoming (15)

Source	Relation	Type	Str
NLRP3	activates	gene	0.60
ASC	activates	gene	0.60
arundic acid	activates	compound	0.60
GFAP	regulates	gene	0.60
MMP24	modulates	gene	0.60
KCNJ10	activates	gene	0.60
CACNA1A	causes	gene	0.60
NLRP3	co_discussed	gene	0.60
APP	associated_with	gene	0.60
APP/PS1	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ALS	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLC1A3

Understanding Entity Pages

Summary

Wiki Pages (21)

slc1a3 Gene

Astrocytes

Tripartite Synapse

OSMR Gene

Glutamatergic Signaling Pathway

Kir4.1 Potassium Channel (KCNJ10)

SLC6A1 Gene

Astrocyte Dysfunction: AD vs PD vs ALS vs FTD vs HD Comparison

KCNJ10 Gene

Glutamate Transport

KCNA1 Gene

Pontine Nuclei

Radial Glia in Neurodegeneration

Single Cell Genomics in Neurodegeneration

Glutamate Signaling Pathway

Astroglia (Astrocytes)

Astrocyte Iron Metabolism and Alpha-Synuclein Pathology in Parkinson's Disease

Bergmann Glia

Ataxin-8 Protein