gene

FGF14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

64Connections

0Hypotheses

0Analyses

41Outgoing

23Incoming

Summary

Gene profile: FGF14 - neuronal FGF family member with critical roles in cerebellar function, synaptic plasticity, and neuronal survival. Mutations cause spinocerebellar ataxia type 27 (SCA27) and are implicated in Alzheimer's and Parkinson's disease pathogenesis.

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🧬 Gene Info

Gene Symbol	FGF14
Full Name	Fibroblast Growth Factor 14
Aliases	SCA27
Chromosome	13q34
Function	is a member of the FGF family with predominant expression in neuronal tissues, particularly in the cerebellum and hippocampus.
Primary Expression	regions connected to substantia nigra
Subcellular Localization	the nuclear compartment
Gene Type	Protein coding
Pathways	Neuroprotection, Synaptic Plasticity, synaptic plasticity
UniProt ID	P15533
NCBI Gene ID	2254
GeneCards	FGF14
Human Protein Atlas	FGF14
Alternative Names	FGF14, FHF-2, FGF14A
Mechanism	Effect
Associated Diseases	Als, Alzheimer, Epilepsy
Interactions	APP, GRIN2A, NLGN1, RORA, KCNIP4, NRXN1
KG Connections	64 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FGF14 — AlphaFold P15533 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FGF14["<b>FGF14</b>"]
    Alzheimer["Alzheimer"]
    FGF14 -->|"activates"| Alzheimer
    GRIN2A["GRIN2A"]
    FGF14 -->|"activates"| GRIN2A
    NLGN1["NLGN1"]
    FGF14 -->|"activates"| NLGN1
    SYNAPSE["SYNAPSE"]
    FGF14 -->|"activates"| SYNAPSE
    Synaptic_Plasticity["Synaptic Plasticity"]
    FGF14 -->|"activates"| Synaptic_Plasticity
    Neuron["Neuron"]
    FGF14 -->|"activates"| Neuron
    RORA["RORA"]
    FGF14 -->|"activates"| RORA
    KCNIP4["KCNIP4"]
    FGF14 -->|"activates"| KCNIP4
    NRXN1["NRXN1"]
    FGF14 -->|"activates"| NRXN1
    NRXN1["NRXN1"]
    NRXN1 -->|"activates"| FGF14
    RORB["RORB"]
    RORB -->|"activates"| FGF14
    KCNIP4["KCNIP4"]
    KCNIP4 -->|"activates"| FGF14
    APP["APP"]
    APP -->|"activates"| FGF14
    NCAM2["NCAM2"]
    NCAM2 -->|"activates"| FGF14
    RORA["RORA"]
    RORA -->|"activates"| FGF14
    SYNAPSE["SYNAPSE"]
    SYNAPSE -->|"activates"| FGF14
    GENES["GENES"]
    GENES -->|"activates"| FGF14
    GRIN2A["GRIN2A"]
    GRIN2A -->|"activates"| FGF14
    AND["AND"]
    AND -->|"activates"| FGF14
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| FGF14
    Prefrontal_Cortex["Prefrontal Cortex"]
    FGF14 -->|"expressed in"| Prefrontal_Cortex
    Cortex["Cortex"]
    FGF14 -->|"expressed in"| Cortex
    Neuron["Neuron"]
    FGF14 -->|"expressed in"| Neuron
    APP["APP"]
    FGF14 -->|"activates"| APP
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| FGF14
    GENES["GENES"]
    GENES -->|"interacts with"| FGF14
    neurodegeneration["neurodegeneration"]
    FGF14 -->|"implicated in"| neurodegeneration

Outgoing (41)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
Als	causes	disease	0.65
Epilepsy	causes	disease	0.65
GRIN2A	activates	gene	0.60
NLGN1	activates	gene	0.60
RORA	activates	gene	0.60
KCNIP4	activates	gene	0.60
NRXN1	activates	gene	0.60
RORB	activates	gene	0.60
Rb	activates	protein	0.60
Purkinje	causes	cell_type	0.60
NPTX1	implicated_in	gene	0.60
PLD3	implicated_in	gene	0.60
PUM1	implicated_in	gene	0.60
STUB1	implicated_in	gene	0.60
PLD3	regulates	gene	0.60
YY1	regulates	gene	0.60
PLD3	interacts_with	gene	0.60
SREBF2	interacts_with	gene	0.60
YY1	interacts_with	gene	0.60
SYNAPSE	activates	gene	0.60
Synaptic Plasticity	activates	pathway	0.60
Neuron	activates	cell_type	0.60
ALZHEIMER	activates	gene	0.60
Actin	activates	protein	0.60
Fgf	activates	protein	0.60
Neuron	causes	cell_type	0.60
Fibroblast	causes	cell_type	0.60
Fgf	causes	protein	0.60
synaptic plasticity	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
Alzheimer	associated_with	disease	0.60
Prefrontal Cortex	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
APP	activates	gene	0.50
NCAM2	activates	gene	0.50
GRIN2A	co_expressed_with	gene	0.50
KCNIP4	co_expressed_with	gene	0.50
NEURONS	activates	concept	0.50
Neuroprotection	activates	process	0.50

Incoming (23)

Source	Relation	Type	Str
NRXN1	activates	gene	0.60
RORB	activates	gene	0.60
KCNIP4	activates	gene	0.60
APP	activates	gene	0.60
NCAM2	activates	gene	0.60
RORA	activates	gene	0.60
GRIN2A	activates	gene	0.60
CACNA1A	causes	gene	0.60
SLC1A3	causes	gene	0.60
KCNA1	causes	gene	0.60
DAB1	implicated_in	gene	0.60
APP	regulates	gene	0.60
AKT3	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
EGR1	interacts_with	gene	0.60
SYNAPSE	activates	gene	0.60
GENES	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
EPILEPSY	causes	gene	0.60
late	activates	disease	0.50
ALZHEIMER	activates	gene	0.50
GENES	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FGF14

Understanding Entity Pages

Summary

Wiki Pages (12)

FGF14 — Fibroblast Growth Factor 14

FGF10 — Fibroblast Growth Factor 10

spinocerebellar-ataxia

Fibroblast Growth Factor Signaling in Neurodegeneration

RORB Gene

KCNA1 Gene

Mark R. Cookson

FGF13 — Fibroblast Growth Factor 13

KCNIP4

FGF22 — Fibroblast Growth Factor 22