Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CACNA1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CACNA1A is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Ms. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | CACNA1A |
| Full Name | Calcium Voltage-Gated Channel Subunit Alpha1 A |
| Aliases | Calcium Channel Alpha-1A Subunit |
| Chromosome | 19p13.13 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | cerebellar Purkinje cells and hippocampal neurons, where it mediates: |
| UniProt ID | O00555 |
| NCBI Gene ID | 773 |
| Ensembl ID | ENSG00000141837 |
| OMIM | 601011 |
| GeneCards | CACNA1A |
| Human Protein Atlas | CACNA1A |
| Brain Region | Expression Level |
| Cerebellum | Very High (Purkinje cells) |
| [Hippocampus](/brain-regions/hippocampus) | High (CA3, dentate gyrus) |
| Associated Diseases | Als, Ms |
| Known Drugs/Compounds | GW201 |
| Interactions | CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H |
| KG Connections | 68 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CACNA1A["<b>CACNA1A</b>"]
Als{"Als"}
CACNA1A -->|"associated with"| Als
Ms{"Ms"}
CACNA1A -->|"associated with"| Ms
CHAT["CHAT"]
CACNA1A -->|"associated with"| CHAT
FERMT2["FERMT2"]
CACNA1A -->|"associated with"| FERMT2
OPTN["OPTN"]
CACNA1A -->|"associated with"| OPTN
GENES["GENES"]
CACNA1A -->|"associated with"| GENES
ABCA1["ABCA1"]
CACNA1A -->|"associated with"| ABCA1
DPM2["DPM2"]
CACNA1A -->|"associated with"| DPM2
TBK1["TBK1"]
CACNA1A -->|"associated with"| TBK1
neurodegeneration["neurodegeneration"]
CACNA1A -->|"implicated in"| neurodegeneration
ATXN2["ATXN2"]
ATXN2 -->|"associated with"| CACNA1A
NORMAL_TENSION_GLAUCOMA["NORMAL TENSION GLAUCOMA"]
NORMAL_TENSION_GLAUCOMA -->|"associated with"| CACNA1A
CHAT -->|"associated with"| CACNA1A
ABCA1 -->|"associated with"| CACNA1A
style CACNA1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Als | causes | disease | 0.65 |
| CHAT | associated_with | gene | 0.60 |
| FERMT2 | associated_with | gene | 0.60 |
| OPTN | associated_with | gene | 0.60 |
| ABCA1 | associated_with | gene | 0.60 |
| DPM2 | associated_with | gene | 0.60 |
| TBK1 | associated_with | gene | 0.60 |
| CCS | contributes_to | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| CACNA2D2 | associated_with | gene | 0.60 |
| CACNA1F | associated_with | gene | 0.60 |
| CACNA1I | associated_with | gene | 0.60 |
| CACNA2D1 | associated_with | gene | 0.60 |
| CACNA1E | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| CACNA1D | associated_with | gene | 0.60 |
| CACNA1G | associated_with | gene | 0.60 |
| SLC1A3 | causes | gene | 0.60 |
| KCNA1 | causes | gene | 0.60 |
| FGF14 | causes | gene | 0.60 |
| Purkinje | causes | cell_type | 0.60 |
| CACNA1D | interacts_with | gene | 0.60 |
| CACNA1E | interacts_with | gene | 0.60 |
| CACNA1F | interacts_with | gene | 0.60 |
| CACNA1G | interacts_with | gene | 0.60 |
| CACNA1H | interacts_with | gene | 0.60 |
| CACNA1I | interacts_with | gene | 0.60 |
| CACNA2D1 | interacts_with | gene | 0.60 |
| CACNA2D2 | interacts_with | gene | 0.60 |
| SCA3 | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| EPILEPSY | causes | gene | 0.60 |
| Neuron | causes | cell_type | 0.60 |
| Fibroblast | causes | cell_type | 0.60 |
| Fgf | causes | protein | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| CACNA1C | interacts_with | gene | 0.50 |
| CACNA1C | co_expressed_with | gene | 0.50 |
| CACNA1D | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GW201 | modulates | compound | 0.85 |
| ATXN2 | associated_with | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| ABCA1 | associated_with | gene | 0.60 |
| CACNA1G | associated_with | gene | 0.60 |
| CACNA1E | associated_with | gene | 0.60 |
| CACNA2D1 | associated_with | gene | 0.60 |
| GAIN | contributes_to | gene | 0.60 |
| CACNA1F | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| CACNA1I | associated_with | gene | 0.60 |
| CACNA1D | associated_with | gene | 0.60 |
| CCS | contributes_to | gene | 0.60 |
| CACNA2D2 | associated_with | gene | 0.60 |
| ACO2 | regulates | gene | 0.60 |
| NORMAL TENSION GLAUCOMA | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| CACNA1D | interacts_with | gene | 0.50 |
| CACNA2D2 | interacts_with | gene | 0.50 |
| CACNA1I | interacts_with | gene | 0.50 |
| CACNA2D1 | interacts_with | gene | 0.50 |
| CACNA1E | interacts_with | protein | 0.50 |
| CACNA1H | interacts_with | protein | 0.50 |
| CACNA1G | interacts_with | protein | 0.50 |
| cacna1f | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||