gene

CACNA1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections
0Hypotheses
0Analyses
42Outgoing
26Incoming

Summary

CACNA1A is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCACNA1A
Full NameCalcium Voltage-Gated Channel Subunit Alpha1 A
AliasesCalcium Channel Alpha-1A Subunit
Chromosome19p13.13
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressioncerebellar Purkinje cells and hippocampal neurons, where it mediates:
UniProt IDO00555
NCBI Gene ID773
Ensembl IDENSG00000141837
OMIM601011
GeneCardsCACNA1A
Human Protein AtlasCACNA1A
Brain RegionExpression Level
CerebellumVery High (Purkinje cells)
[Hippocampus](/brain-regions/hippocampus)High (CA3, dentate gyrus)
Associated DiseasesAls, Ms
Known Drugs/CompoundsGW201
InteractionsCACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H
KG Connections68 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CACNA1A — AlphaFold O00555 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CACNA1A — Calcium Channel Alpha-1A Subunit

gene · 745 words

calcium-dysregulation-comparison

mechanism · 6468 words

Cerebellar Function

mechanism · 4485 words

Ion Channel Dysfunction in Huntington's Disease

mechanism · 3782 words

Climbing Fiber Inputs

cell · 3564 words

Calcium Dysregulation in Neurodegeneration

mechanism · 3529 words

Pathway Diagram

graph TD
    CACNA1A["<b>CACNA1A</b>"]
    Als{"Als"}
    CACNA1A -->|"associated with"| Als
    Ms{"Ms"}
    CACNA1A -->|"associated with"| Ms
    CHAT["CHAT"]
    CACNA1A -->|"associated with"| CHAT
    FERMT2["FERMT2"]
    CACNA1A -->|"associated with"| FERMT2
    OPTN["OPTN"]
    CACNA1A -->|"associated with"| OPTN
    GENES["GENES"]
    CACNA1A -->|"associated with"| GENES
    ABCA1["ABCA1"]
    CACNA1A -->|"associated with"| ABCA1
    DPM2["DPM2"]
    CACNA1A -->|"associated with"| DPM2
    TBK1["TBK1"]
    CACNA1A -->|"associated with"| TBK1
    neurodegeneration["neurodegeneration"]
    CACNA1A -->|"implicated in"| neurodegeneration
    ATXN2["ATXN2"]
    ATXN2 -->|"associated with"| CACNA1A
    NORMAL_TENSION_GLAUCOMA["NORMAL TENSION GLAUCOMA"]
    NORMAL_TENSION_GLAUCOMA -->|"associated with"| CACNA1A
    CHAT -->|"associated with"| CACNA1A
    ABCA1 -->|"associated with"| CACNA1A
    style CACNA1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (42)

TargetRelationTypeStr
Alsassociated_withdisease0.65
Msassociated_withdisease0.65
Alscausesdisease0.65
CHATassociated_withgene0.60
FERMT2associated_withgene0.60

Incoming (26)

SourceRelationTypeStr
GW201modulatescompound0.85
ATXN2associated_withgene0.60
CHATassociated_withgene0.60
ABCA1associated_withgene0.60
CACNA1Gassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found