Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LC3-ASSOCIATED PHAGOCYTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | LC3-ASSOCIATED PHAGOCYTOSIS |
Knowledge base pages for this entity
graph TD
LC3_ASSOCIATED_PHAGOCYTOSIS["LC3-ASSOCIATED PHAGOCYTOSIS"]
LC3_ASSOCIATED_PHAGOCYTOSIS -->|"promotes"| antibacterial_response["antibacterial response"]
LC3_ASSOCIATED_PHAGOCYTOSIS -->|"permits"| FOXP3_activation["FOXP3 activation"]
LC3_ASSOCIATED_PHAGOCYTOSIS -->|"inhibits"| macroautophagy["macroautophagy"]
LC3_ASSOCIATED_PHAGOCYTOSIS -->|"targets"| Bacteria["Bacteria"]
LC3_ASSOCIATED_PHAGOCYTOSIS -->|"modulates"| autophagic_machinery["autophagic machinery"]
LC3_ASSOCIATED_PHAGOCYTOSIS -->|"contributes to"| Bacterial_Pathogen_Control["Bacterial Pathogen Control"]
LC3_ASSOCIATED_PHAGOCYTOSIS -->|"activates"| debris_clearance["debris clearance"]
V_ATPASE["V-ATPASE"] -->|"regulates"| LC3_ASSOCIATED_PHAGOCYTOSIS
macrophages["macrophages"] -->|"expressed in"| LC3_ASSOCIATED_PHAGOCYTOSIS
NADPH_OXIDASE["NADPH OXIDASE"] -->|"involved_in"| LC3_ASSOCIATED_PHAGOCYTOSIS
Ros["Ros"] -->|"involved_in"| LC3_ASSOCIATED_PHAGOCYTOSIS
pattern_recognition_receptors["pattern-recognition receptors"] -->|"upstream_of"| LC3_ASSOCIATED_PHAGOCYTOSIS
LC3["LC3"] -->|"participates in"| LC3_ASSOCIATED_PHAGOCYTOSIS
V_ATPase["V-ATPase"] -->|"regulates"| LC3_ASSOCIATED_PHAGOCYTOSIS| Target | Relation | Type | Str |
|---|---|---|---|
| antibacterial response | promotes | process | 0.90 |
| FOXP3 activation | permits | process | 0.88 |
| macroautophagy | inhibits | process | 0.88 |
| FOXP3 activation | promotes | phenotype | 0.88 |
| ATG8-PS | associated_with | protein | 0.85 |
| Bacteria | targets | organism | 0.85 |
| autophagic machinery | modulates | process | 0.82 |
| Bacterial Pathogen Control | contributes_to | process | 0.80 |
| debris clearance | activates | process | 0.70 |
| innate immune function | regulates | process | 0.70 |
| immunity | associated_with | process | 0.70 |
| inflammation | regulates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| V-ATPASE | regulates | protein | 0.95 |
| macrophages | expressed_in | cell_type | 0.90 |
| NADPH OXIDASE | involved_in | enzyme | 0.85 |
| Ros | involved_in | compound | 0.85 |
| pattern-recognition receptors | upstream_of | protein | 0.85 |
| LC3 | participates_in | protein | 0.80 |
| LC3 | regulates | protein | 0.70 |
| V-ATPase | regulates | protein | 0.70 |
| STING | activates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||