ROS

Understanding Entity Pages

This page aggregates everything SciDEX knows about ROS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

ROS is a phenotype associated with neurodegeneration research. Key relationships include: activates, interacts with, regulates. Associated with AD, ALI, ALS. Connected to 1918 entities in the SciDEX knowledge graph.

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graph TD
    subgraph Signaling["Signaling"]
        ROS["ROS"] -->|"activates"| NRF2["NRF2"]
        ROS["ROS"] -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
        ROS["ROS"] -->|"activates"| FERROPTOSIS_1["FERROPTOSIS"]
        ROS["ROS"] -->|"regulates"| PI3K["PI3K"]
        ROS["ROS"] -->|"activates"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
        ROS["ROS"] -->|"regulates"| GENES["GENES"]
        ROS["ROS"] -->|"activates"| ALZHEIMER["ALZHEIMER"]
        SLC7A11["SLC7A11"] -.->|"inhibits"| ROS["ROS"]
        AUTOPHAGY_2["AUTOPHAGY"] -->|"activates"| ROS["ROS"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| ROS["ROS"]
        MITOPHAGY["MITOPHAGY"] -->|"activates"| ROS["ROS"]
        SLC7A11_3["SLC7A11"] -->|"activates"| ROS["ROS"]
        BAX["BAX"] -->|"activates"| ROS["ROS"]
    end
    subgraph Pathology["Pathology"]
        ROS["ROS"] -->|"causes"| DNA["DNA"]
        ROS["ROS"] -->|"causes"| FERROPTOSIS["FERROPTOSIS"]
    end
    style ROS fill:#5d4400,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style NRF2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style DNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style FERROPTOSIS fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style FERROPTOSIS_1 fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PI3K fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style GENES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SLC7A11 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MITOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SLC7A11_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style BAX fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0