gene

LGI1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LGI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections

0Hypotheses

0Analyses

9Outgoing

2Incoming

0Experiments

0Debates

Summary

LGI1 (Leucine-Rich Glioma Inactivated 1) encodes a synaptic protein that interacts with ADAM22/ADAM23 receptors to regulate AMPA receptor trafficking, synaptic transmission, and neuronal excitability. Implicated in ADLTE, Alzheimer's disease, and prion diseases.

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🧬 Gene Info

Gene Symbol	LGI1
Full Name	Leucine-Rich Glioma Inactivated 1
Chromosome	10q24.3
Protein Type	Receptor
Function	encodes a secreted neuronal protein that serves as a critical regulator of synaptic transmission and neuronal excitability.
Primary Expression	brain with potential roles in neuronal function
Subcellular Localization	- Synaptic terminals: Secreted at both presynaptic and postsynaptic sites
Molecular Weight	63 kDa
Amino Acids	557 aa
UniProt ID	O75771
NCBI Gene ID	2709
Ensembl ID	ENSG00000162711
OMIM	604619
GeneCards	LGI1
Human Protein Atlas	LGI1
Associated Diseases	neurodegeneration
KG Connections	11 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LGI1 — AlphaFold O75771 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["LGI1"]
    N1["Cancer"]
    N0 -->|"treats"| N1
    N2["Als"]
    N0 -->|"treats"| N2
    N3["Inflammation"]
    N0 -->|"treats"| N3
    N4["Autoimmune"]
    N0 -->|"treats"| N4
    N5["Anxiety"]
    N0 -->|"treats"| N5
    N6["INFLAMMATION"]
    N0 -->|"treats"| N6
    N7["ANXIETY"]
    N0 -->|"treats"| N7
    N8["CANCER"]
    N0 -->|"treats"| N8
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 disease
    class N5 disease
    class N6 gene
    class N7 gene
    class N8 gene

Outgoing (9)

Target	Relation	Type	Str
Inflammation	treats	disease	0.65
Autoimmune	treats	disease	0.65
Anxiety	treats	disease	0.65
Cancer	treats	disease	0.65
Als	treats	disease	0.65
oligodendrocytes	expressed_in	cell_type	0.60
ANXIETY	treats	gene	0.60
CANCER	treats	gene	0.60
INFLAMMATION	treats	gene	0.60

Incoming (2)

Source	Relation	Type	Str
genes-lgi1	documents	wiki	1.00
genes-lgi1	describes	wiki	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LGI1 in their description or question text

No additional research found