gene

MAPK9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

12Outgoing

2Incoming

0Experiments

0Debates

Summary

MAPK9 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Alzheimer, Ms. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAPK9
Chromosome	5q33.1
Function	is a critical regulator of cellular stress responses, inflammation, cell proliferation, and apoptosis.
Primary Expression	various tissues, JNK3 (MAPK10) is primarily expressed in neurons
Molecular Weight	48 kDa
Amino Acids	424 aa
Exons	18
Pathways	MAPK, NF-κB
GeneCards	MAPK9
Human Protein Atlas	MAPK9
Genomic position	~179,500,000-179,560,000 (GRCh38)
Exon count	18 exons
Protein length	Varies by isoform (JNK2α: 424 amino acids; JNK2β: 427 amino acids)
Molecular weight	Approximately 46-48 kDa
Cellular stress	UV radiation, oxidative stress, cytokines
Associated Diseases	Alzheimer, Ms
KG Connections	14 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAPK9["MAPK9"]
    Alzheimer{"Alzheimer"}
    MAPK9 -->|"associated with"| Alzheimer
    Ms{"Ms"}
    MAPK9 -->|"associated with"| Ms
    AUTOPHAGY["AUTOPHAGY"]
    MAPK9 -->|"associated with"| AUTOPHAGY
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    MAPK9 -->|"associated with"| OXIDATIVE_STRESS
    TFEB["TFEB"]
    MAPK9 -->|"associated with"| TFEB
    Autophagy(["Autophagy"])
    MAPK9 -->|"associated with"| Autophagy
    Mapk(["Mapk"])
    MAPK9 -->|"associated with"| Mapk
    Oxidative_Stress(["Oxidative Stress"])
    MAPK9 -->|"associated with"| Oxidative_Stress
    Immune_Response(["Immune Response"])
    MAPK9 -->|"associated with"| Immune_Response
    neurodegeneration["neurodegeneration"]
    MAPK9 -->|"implicated in"| neurodegeneration
    BAX["BAX"]
    BAX -->|"associated with"| MAPK9
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| MAPK9
    style MAPK9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
OXIDATIVE STRESS	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Mapk	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
TFEB	associated_with	gene	0.60
Immune Response	associated_with	pathway	0.60
AUTOPHAGY	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
BAX	associated_with	gene	0.60

Incoming (2)

Source	Relation	Type	Str
BAX	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK9 in their description or question text

No additional research found