Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MARK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | MARK2 |
| Protein Type | Serine/Threonine Kinase |
| Function | is a serine/threonine kinase that phosphorylates microtubule-associated proteins (MAPs) including tau, regulating microtubule dynamics and neuronal polarity. |
| Molecular Weight | 80 kDa |
| Pathways | AMPK |
| Ensembl ID | ENSG00000072518 |
| GeneCards | MARK2 |
| Human Protein Atlas | MARK2 |
| Ser262 phosphorylation | The primary MARK2 target on tau; phosphorylation at this site alone reduces tau-microtubule binding by ~10-fold |
| Ser356 phosphorylation | Second major target; combined Ser262/Ser356 phosphorylation virtually abolishes tau-microtubule interaction |
| Microtubule destabilization | By detaching tau, MARK2 increases microtubule dynamic instability, enabling cytoskeletal remodeling |
| Transport regulation | MARK2-mediated tau phosphorylation clears microtubule tracks, facilitating kinesin and dynein-dependent axonal transport |
| Axon specification | MARK2 activity is required for the break in symmetry that selects one neurite to become the axon |
| Par complex interaction | MARK2 phosphorylates Par-3 (PARD3), disrupting the Par-3/Par-6/aPKC polarity complex and establishing axonal identity |
| Growth cone dynamics | Regulates actin-microtubule cross-talk at the growth cone through MAP phosphorylation |
| Associated Diseases | ALS, autism spectrum disorder |
| Interactions | AUTOPHAGY |
| KG Connections | 19 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MARK2["<b>MARK2</b>"]
Als{"Als"}
MARK2 -->|"expressed in"| Als
Autism{"Autism"}
MARK2 -->|"inhibits"| Autism
C9ORF72["C9ORF72"]
MARK2 -->|"regulates"| C9ORF72
Wnt(["Wnt"])
MARK2 -->|"inhibits"| Wnt
neurodegeneration["neurodegeneration"]
MARK2 -->|"implicated in"| neurodegeneration
RAN["RAN"]
RAN -->|"regulates"| MARK2
style MARK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| Autism | inhibits | disease | 0.65 |
| C9ORF72 | regulates | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| GABARAP | regulates | gene | 0.60 |
| Wnt | inhibits | pathway | 0.60 |
| AND | regulates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Unfolded Protein Response | regulates | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| autism spectrum disorder | interacts_with | disease | 0.60 |
| autism spectrum disorder | associated_with | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| CRISPR-Cas | participates_in | pathway | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RAN | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||