protein

GABARAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABARAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

980Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

GABARAP is a protein involved in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with ALS, Aging, Als. Connected to 490 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	GABARAP
Full Name	GABA Type A Receptor Associated Protein
Chromosome	17p13.1
Function	GABARAP is a member of the ATG8 family (MAP1LC3/GABARAP family) with multiple cellular functions
Gene Type	Protein-coding (ATG8 family)
Pathways	Akt, Autophagy, Endocytosis, Er Stress, Lysosomal Degradation
UniProt ID	O95166
NCBI Gene ID	23710
Ensembl ID	ENSG00000138967
OMIM	607418
GeneCards	GABARAP
Human Protein Atlas	GABARAP
Disease	Inheritance
Agent	Target
Small molecule autophagy inducers	ATG proteins
Associated Diseases	ALS, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia, Cancer
Known Drugs/Compounds	rapamycin
Interactions	ERN1, STAT3, IFNG, LC3, RPTOR, RB1
KG Connections	979 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GABARAP — AlphaFold O95166 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GABARAP["GABARAP"] -->|"interacts"| Cancer["Cancer"]
    GABARAP["GABARAP"] -->|"interacts"| Als["Als"]
    GABARAP["GABARAP"] -->|"interacts"| Ms["Ms"]
    GABARAP["GABARAP"] -->|"interacts"| Fibrosis["Fibrosis"]
    GABARAP["GABARAP"] -->|"interacts"| Aging["Aging"]
    GABARAP["GABARAP"] -->|"associated"| Ms_1["Ms"]
    OPTN["OPTN"] -->|"interacts"| GABARAP["GABARAP"]
    CASP3["CASP3"] -->|"interacts"| GABARAP["GABARAP"]
    AKT1["AKT1"] -->|"interacts"| GABARAP["GABARAP"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| GABARAP["GABARAP"]
    style GABARAP fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (604)

Target	Relation	Type	Str
LRRK2	binds	gene	0.95
NUFIP2	interacts_with	protein	0.90
FLCN-FNIP complex	binds_to	protein	0.90
PLEKHM1	interacts_with	protein	0.90
autophagy pathway	participates_in	pathway	0.90
TFEB	inhibits	protein	0.88
Damaged Lysosomes	interacts_with	cell_type	0.85
FLCN-FNIP Complex	binds	protein	0.85
FLCN	binds	protein	0.85
FNIP1	binds	protein	0.85
FNIP	binds	protein	0.85
mTORC1	inhibits	enzyme	0.82
LRRK2	regulates	protein	0.80
autophagy receptors	component_of	protein	0.80
chaperone-assisted selective autophagy	participates_in	pathway	0.80
autophagy	participates_in	pathway	0.80
LC3	activates	gene	0.80
TFEB	regulates	gene	0.80
RNA	activates	gene	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
RNA	regulates	gene	0.80
Autophagy	interacts_with	pathway	0.80
Gaba Receptor Trafficking	promotes	process	0.75
Als	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
MTOR	associated_with	gene	0.70
LC3	associated_with	gene	0.70
PRKN	associated_with	gene	0.70
RB1CC1	associated_with	gene	0.70
PIK3C3	associated_with	gene	0.70
WIPI2	associated_with	gene	0.70
TFEB	associated_with	gene	0.70
UBIQUITIN	associated_with	gene	0.70
RB1	activates	gene	0.70
PIK3C3	regulates	gene	0.70
RB1	regulates	gene	0.70
RB1CC1	regulates	gene	0.70
SQSTM1	regulates	gene	0.70
LAMP2	regulates	gene	0.70
MAP1LC3B	regulates	gene	0.70
Mtor	associated_with	pathway	0.70
Autophagy	associated_with	pathway	0.70
ATG	associated_with	gene	0.70
Lysosomal Degradation	regulates	pathway	0.70
AUTOPHAGY	associated_with	gene	0.70
oxidative stress response	participates_in	pathway	0.70
stem cells	expressed_in	cell_type	0.70
RAS	activates	gene	0.70

Incoming (376)

Source	Relation	Type	Str
TRIM22	mediates	protein	0.92
rapamycin	targets	drug	0.90
GABA	regulates	gene	0.90
STING	upregulates	protein	0.85
STING	modulates	protein	0.85
STING	interacts_with	gene	0.80
CASM	modulates	protein	0.80
ATG	regulates	gene	0.80
LC3	interacts_with	gene	0.80
AUTOPHAGY	interacts_with	gene	0.80
TAX1BP1	interacts_with	gene	0.70
RB1	associated_with	gene	0.70
GABARAPL1	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
BECN1	regulates	gene	0.70
TRIM22	interacts_with	protein	0.70
ATG	activates	gene	0.70
AUTOPHAGY	activates	gene	0.70
CANCER	activates	gene	0.70
LC3B	associated_with	gene	0.70
DNA	regulates	gene	0.70
OPTN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
ULK1	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
RAB9A	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
GLA	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
GABARAPL1	expressed_in	gene	0.60
GABRB1	expressed_in	gene	0.60
ATF4	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
AMBRA1	associated_with	gene	0.60
ALS4	associated_with	gene	0.60
BNIP3	activates	gene	0.60
STING	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GABARAP

Understanding Entity Pages

Summary

Wiki Pages (21)

GABARAP Gene

Mitochondrial Quality Control

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

mitophagy-defect

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

ZFYVE26 Gene

Mitophagy Pathway in Neurodegeneration

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

autophagy-lysosome-dysfunction

MAP1LC3A Gene

RETREG3 (Reticulophagy Regulator 3)

Mitophagy

autophagy

VCP→TDP-43→ALS/FTD Causal Chain

OPTN Protein (Optineurin)

SQSTM1 — Sequestosome 1 (p62)

Cysteine String Protein (CSP)

Cerebellar Purkinje Cells in Motor Coordination