pathway

Unfolded Protein Response

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Unfolded Protein Response: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1129Connections

0Hypotheses

0Analyses

42Outgoing

50Incoming

Summary

Unfolded Protein Response is a biological pathway involved in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with Aging, Als, Alzheimer. Connected to 386 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Unfolded Protein Response
Summary	# [Unfolded Protein Response](/entities/unfolded-protein-response)[/entities/unfolded-protein-response](entities/unfolded-protein-response) ## Introduction [Unfolded Protein Response](/entities/unfol
Key Genes/Proteins	APOPTOSIS, AUTOPHAGY, GENES, OXIDATIVE STRESS
Related Diseases	Als, Cancer

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Unfolded_Protein_Response["Unfolded Protein Response"] -->|"interacts"| Mtor["Mtor"]
    Unfolded_Protein_Response["Unfolded Protein Response"] -->|"interacts"| Apoptosis["Apoptosis"]
    Unfolded_Protein_Response["Unfolded Protein Response"] -->|"interacts"| Autophagy["Autophagy"]
    Unfolded_Protein_Response["Unfolded Protein Response"] -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    SPHK1["SPHK1"] -->|"activates"| Unfolded_Protein_Response["Unfolded Protein Response"]
    TARDBP["TARDBP"] -->|"activates"| Unfolded_Protein_Response["Unfolded Protein Response"]
    PINK1["PINK1"] -->|"activates"| Unfolded_Protein_Response["Unfolded Protein Response"]
    LC3["LC3"] -->|"activates"| Unfolded_Protein_Response["Unfolded Protein Response"]
    style Unfolded_Protein_Response fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (146)

Target	Relation	Type	Str
Protein Folding	modulates	process	0.90
Protein Quality Control	activates	process	0.90
Neuronal Apoptosis	mediates	process	0.90
Protein Folding	regulates	process	0.90
Protein Degradation	associated_with	process	0.85
Apoptosis	associated_with	process	0.85
Dipeptide Repeat Protein Aggregation	involved_in	process	0.85
Neurodegeneration	contributes_to	process	0.80
Synaptic Function	associated_with	process	0.75
Cognition	associated_with	phenotype	0.75
Memory	associated_with	phenotype	0.75
Mtor	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Oxidative Stress	interacts_with	pathway	0.55
Neuron	activates	cell_type	0.50
Stem Cell	activates	cell_type	0.50
Ubiquitin-Proteasome	activates	pathway	0.50
disease	activates	disease	0.50
FRONTOTEMPORAL	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
IPSC	activates	concept	0.50
Reactive Oxygen Species	activates	process	0.50
Protein Folding	activates	pathway	0.50
Protein Aggregation	activates	process	0.50
Dendritic Cell	activates	cell_type	0.50
COLORECTAL CANCER	activates	disease	0.50
Microrna	activates	pathway	0.50
Inflammatory Bowel Disease	activates	disease	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
APP/PS1	activates	concept	0.50
Proteins	associated_with	protein	0.50
Astrocyte	activates	cell_type	0.50
Microglia	activates	cell_type	0.50
Neuron	stabilizes	cell_type	0.50
Schwann Cell	activates	cell_type	0.50
Stem Cell	associated_with	cell_type	0.50
Dendritic Cell	associated_with	cell_type	0.50
Epithelial	associated_with	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Fibroblast	associated_with	cell_type	0.50

Incoming (983)

Source	Relation	Type	Str
APOPTOSIS	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
GENES	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
Endoplasmic Reticulum Stress	associated_with	process	0.95
ER Stress	activates	process	0.95
Endoplasmic Reticulum	activates	organelle	0.95
GSK2606414	inhibits	drug	0.90
Als	activates	disease	0.90
Als	therapeutic_target	disease	0.90
Cancer	therapeutic_target	disease	0.90
Tdp-43 Fibrils	activates	protein	0.87
DNA	activates	gene	0.80
Inflammation	activates	disease	0.80
Obesity	activates	disease	0.80
Hepatitis	therapeutic_target	disease	0.80
FERROPTOSIS	activates	gene	0.80
CANCER	activates	gene	0.80
CANCER	therapeutic_target	gene	0.80
Cancer	activates	disease	0.80
LC3	activates	gene	0.70
TBK1	activates	gene	0.70
ATG	activates	gene	0.70
Neurodegeneration	activates	disease	0.70
Neurodegeneration	associated_with	disease	0.70
Neuroinflammation	activates	disease	0.70
Fibrosis	activates	disease	0.70
BIP	activates	gene	0.70
CHOP	activates	gene	0.70
Alzheimer	activates	disease	0.70
Inflammation	therapeutic_target	disease	0.70
AUTOPHAGY	regulates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
BCL-2	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
APOPTOSIS	regulates	gene	0.70
MITOCHONDRIAL DNA	activates	gene	0.70
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
UBIQUITIN	activates	gene	0.70
NEURODEGENERATIVE DISEASES	activates	gene	0.70
NEURODEGENERATION	associated_with	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70
MICROGLIA	activates	gene	0.70
Tumor	inhibits	disease	0.70
Cardiovascular	implicated_in	disease	0.70
Als	implicated_in	disease	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Unfolded Protein Response

Understanding Entity Pages

Summary

Wiki Pages (21)