Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MATRIN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | MATR3 |
| Full Name | Matrin 3 |
| Aliases | MATA3, ATMR1 |
| Chromosome | 5q31.2 |
| Function | Matr3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Subcellular Localization | Signals (NLS)**: Two NLS sequences for nuclear import - **C-terminal domain**: M |
| Molecular Weight | 125 kDa |
| Amino Acids | 847 aa |
| Pathways | Autophagy, Proteasome, Dna Repair, autophagy pathway |
| UniProt ID | P43243 |
| NCBI Gene ID | 9782 |
| Ensembl ID | ENSG00000015479 |
| GeneCards | MATR3 |
| Human Protein Atlas | MATR3 |
| Associated Diseases | ALS, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia, Multisystem Proteinopathy |
| Interactions | RANK, NEURODEGENERATION, MOTOR NEURONS, AUTOPHAGY, AMYOTROPHIC LATERAL SCLEROSIS, GAIN |
| KG Connections | 143 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
MATRIN3["MATRIN3"]
ALS["ALS"]
MATRIN3 -->|"associated_with"| ALS
Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
MATRIN3 -->|"regulates"| Amyotrophic_Lateral_Sclerosis
Aging["Aging"]
MATRIN3 -->|"regulates"| Aging
Proteasome["Proteasome"]
MATRIN3 -->|"regulates"| Proteasome
Tdp_43["Tdp-43"]
MATRIN3 -->|"associated_with"| Tdp_43
Autophagy["Autophagy"]
MATRIN3 -->|"regulates"| Autophagy
Ubiquitin_Proteasome["Ubiquitin-Proteasome"]
MATRIN3 -->|"regulates"| Ubiquitin_Proteasome
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"regulates"| MATRIN3
HSP90["HSP90"]
HSP90 -->|"regulates"| MATRIN3
FUS["FUS"]
FUS -->|"associated_with"| MATRIN3
DNAJC7["DNAJC7"]
DNAJC7 -->|"regulates"| MATRIN3
SOD1["SOD1"]
SOD1 -->|"associated_with"| MATRIN3
Neuron["Neuron"]
MATRIN3 -->|"expressed_in"| Neuron
neurodegeneration["neurodegeneration"]
MATRIN3 -->|"implicated_in"| neurodegeneration
style MATRIN3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | associated_with | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| Proteasome | regulates | pathway | 0.60 |
| Tdp-43 | associated_with | pathway | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Ubiquitin-Proteasome | regulates | pathway | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||