protein

DNAJC7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections
0Hypotheses
0Analyses
50Outgoing
12Incoming

Summary

DNAJC7 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, implicated in. Associated with Als, Amyotrophic Lateral Sclerosis, Cancer. Connected to 33 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolDNAJC7
Full NameDnaJ Heat Shock Protein Family (Hsp40) Member C7
Chromosome12q24.31
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight55 kDa
Amino Acids70 aa
PathwaysAutophagy, Proteasome, Tdp-43, Ubiquitin-Proteasome
UniProt IDQ9H0U4
NCBI Gene IDDNAJC7
GeneCardsDNAJC7
Human Protein AtlasDNAJC7
Gene| [@dnajca]
Associated DiseasesALS, Amyotrophic Lateral Sclerosis
InteractionsHSP90
KG Connections62 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: DNAJC7 — AlphaFold Q9H0U4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

DnaJ Heat Shock Protein Family (Hsp40) Member C7

gene · 883 words

Chaperone-Mediated Proteostasis Disease Comparison

mechanism · 2782 words

dnajc4

gene · 2075 words

DNAJC28 Gene

gene · 1319 words

CTSF Gene (CLN10)

gene · 971 words

MFSD8 — Major Facilitator Superfamily Domain Containing 8

gene · 857 words

Pathway Diagram

graph TD
    DNAJC7["<b>DNAJC7</b>"]
    Lymphoma{"Lymphoma"}
    DNAJC7 -->|"expressed in"| Lymphoma
    Ms{"Ms"}
    DNAJC7 -->|"expressed in"| Ms
    Cancer{"Cancer"}
    DNAJC7 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    DNAJC7 -->|"expressed in"| Tumor
    Als{"Als"}
    DNAJC7 -->|"regulates"| Als
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    DNAJC7 -->|"regulates"| Amyotrophic_Lateral_Sclerosis
    HSPA6["HSPA6"]
    DNAJC7 -->|"expressed in"| HSPA6
    DNAJB1["DNAJB1"]
    DNAJC7 -->|"expressed in"| DNAJB1
    IKBKB["IKBKB"]
    DNAJC7 -->|"expressed in"| IKBKB
    HSPA1B["HSPA1B"]
    DNAJC7 -->|"expressed in"| HSPA1B
    HSPE1["HSPE1"]
    DNAJC7 -->|"expressed in"| HSPE1
    HSP90AB1["HSP90AB1"]
    DNAJC7 -->|"expressed in"| HSP90AB1
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"expressed in"| DNAJC7
    CANCER["CANCER"]
    CANCER -->|"expressed in"| DNAJC7
    BAG3["BAG3"]
    BAG3 -->|"expressed in"| DNAJC7
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"expressed in"| DNAJC7
    UBC["UBC"]
    UBC -->|"expressed in"| DNAJC7
    HSPD1["HSPD1"]
    HSPD1 -->|"expressed in"| DNAJC7
    NF__B["NF-KappaB"]
    NF__B -->|"expressed in"| DNAJC7
    style DNAJC7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (50)

TargetRelationTypeStr
Lymphomaexpressed_indisease0.65
Msexpressed_indisease0.65
Cancerexpressed_indisease0.65
Tumorexpressed_indisease0.65
Alsregulatesdisease0.65

Incoming (12)

SourceRelationTypeStr
UBIQUITINexpressed_ingene0.60
BAG3expressed_ingene0.60
UBCexpressed_ingene0.60
HSPD1expressed_ingene0.60
UBIQUITINregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found