Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJC7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DNAJC7 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, implicated in. Associated with Als, Amyotrophic Lateral Sclerosis, Cancer. Connected to 33 entities in the SciDEX knowledge graph.
| Gene Symbol | DNAJC7 |
| Full Name | DnaJ Heat Shock Protein Family (Hsp40) Member C7 |
| Chromosome | 12q24.31 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 55 kDa |
| Amino Acids | 70 aa |
| Pathways | Autophagy, Proteasome, Tdp-43, Ubiquitin-Proteasome |
| UniProt ID | Q9H0U4 |
| NCBI Gene ID | DNAJC7 |
| GeneCards | DNAJC7 |
| Human Protein Atlas | DNAJC7 |
| Gene | | [@dnajca] |
| Associated Diseases | ALS, Amyotrophic Lateral Sclerosis |
| Interactions | HSP90 |
| KG Connections | 62 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJC7["<b>DNAJC7</b>"]
Lymphoma{"Lymphoma"}
DNAJC7 -->|"expressed in"| Lymphoma
Ms{"Ms"}
DNAJC7 -->|"expressed in"| Ms
Cancer{"Cancer"}
DNAJC7 -->|"expressed in"| Cancer
Tumor{"Tumor"}
DNAJC7 -->|"expressed in"| Tumor
Als{"Als"}
DNAJC7 -->|"regulates"| Als
Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
DNAJC7 -->|"regulates"| Amyotrophic_Lateral_Sclerosis
HSPA6["HSPA6"]
DNAJC7 -->|"expressed in"| HSPA6
DNAJB1["DNAJB1"]
DNAJC7 -->|"expressed in"| DNAJB1
IKBKB["IKBKB"]
DNAJC7 -->|"expressed in"| IKBKB
HSPA1B["HSPA1B"]
DNAJC7 -->|"expressed in"| HSPA1B
HSPE1["HSPE1"]
DNAJC7 -->|"expressed in"| HSPE1
HSP90AB1["HSP90AB1"]
DNAJC7 -->|"expressed in"| HSP90AB1
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"expressed in"| DNAJC7
CANCER["CANCER"]
CANCER -->|"expressed in"| DNAJC7
BAG3["BAG3"]
BAG3 -->|"expressed in"| DNAJC7
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"expressed in"| DNAJC7
UBC["UBC"]
UBC -->|"expressed in"| DNAJC7
HSPD1["HSPD1"]
HSPD1 -->|"expressed in"| DNAJC7
NF__B["NF-KappaB"]
NF__B -->|"expressed in"| DNAJC7
style DNAJC7 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Lymphoma | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 0.65 |
| Aging | regulates | disease | 0.65 |
| HSPA6 | expressed_in | gene | 0.60 |
| DNAJB1 | expressed_in | gene | 0.60 |
| IKBKB | expressed_in | gene | 0.60 |
| HSPA1B | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| HSP90AB1 | expressed_in | gene | 0.60 |
| HSP70 | expressed_in | gene | 0.60 |
| HSPH1 | expressed_in | gene | 0.60 |
| HSPA1L | expressed_in | gene | 0.60 |
| HSPA1A | expressed_in | gene | 0.60 |
| DNAJC10 | expressed_in | gene | 0.60 |
| HSF1 | regulates | gene | 0.60 |
| BAG3 | expressed_in | gene | 0.60 |
| UBC | expressed_in | gene | 0.60 |
| UBIQUITIN | expressed_in | gene | 0.60 |
| HSPD1 | expressed_in | gene | 0.60 |
| HSP60 | expressed_in | gene | 0.60 |
| SOD1 | regulates | gene | 0.60 |
| MATRIN3 | regulates | gene | 0.60 |
| GLT8D1 | implicated_in | gene | 0.60 |
| KIF5A | implicated_in | gene | 0.60 |
| MFSD8 | implicated_in | gene | 0.60 |
| NEK1 | implicated_in | gene | 0.60 |
| TBK1 | implicated_in | gene | 0.60 |
| TBP | implicated_in | gene | 0.60 |
| PHAGOCYTOSIS | expressed_in | gene | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Unfolded Protein Response | expressed_in | pathway | 0.60 |
| Nf-Κb | expressed_in | pathway | 0.60 |
| Phagocytosis | expressed_in | pathway | 0.60 |
| ALS | regulates | gene | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | regulates | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| Proteasome | regulates | pathway | 0.60 |
| Tdp-43 | regulates | pathway | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Ubiquitin-Proteasome | regulates | pathway | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| UBIQUITIN | expressed_in | gene | 0.60 |
| BAG3 | expressed_in | gene | 0.60 |
| UBC | expressed_in | gene | 0.60 |
| HSPD1 | expressed_in | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| HSP90 | interacts_with | gene | 0.60 |
| FUS | regulates | gene | 0.60 |
| CCNF | implicated_in | gene | 0.60 |
| CTSF | implicated_in | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||