Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MITOCHONDRIAL FRAGMENTATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MITOCHONDRIAL FRAGMENTATION |
Knowledge base pages for this entity
graph TD
MITOCHONDRIAL_FRAGMENTATION["MITOCHONDRIAL FRAGMENTATION"]
MITOCHONDRIAL_FRAGMENTATION -->|"inhibits"| ATP_Production["ATP Production"]
MITOCHONDRIAL_FRAGMENTATION -->|"contributes to"| Dysfunctional_Mitochondria_Rel["Dysfunctional Mitochondria Release"]
MITOCHONDRIAL_FRAGMENTATION -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
DRP1["DRP1"] -->|"mediates"| MITOCHONDRIAL_FRAGMENTATION
SARS_COV_2_MEMBRANE_PROTEIN["SARS-COV-2 MEMBRANE PROTEIN"] -->|"causes"| MITOCHONDRIAL_FRAGMENTATION
SARS_CoV_2_M_Protein["SARS-CoV-2 M Protein"] -->|"causes"| MITOCHONDRIAL_FRAGMENTATION
palmitic_acid["palmitic acid"] -->|"causes"| MITOCHONDRIAL_FRAGMENTATION
TRPML1["TRPML1"] -.prevents.-> MITOCHONDRIAL_FRAGMENTATION
PINK1["PINK1"] -->|"inhibits"| MITOCHONDRIAL_FRAGMENTATION
oxidative_stress["oxidative stress"] -->|"causes"| MITOCHONDRIAL_FRAGMENTATION| Target | Relation | Type | Str |
|---|---|---|---|
| ATP Production | inhibits | process | 0.95 |
| Dysfunctional Mitochondria Release | contributes_to | process | 0.90 |
| Dysfunctional Mitochondria Release | regulates | process | 0.90 |
| Oxidative Stress | causes | process | 0.90 |
| Oxidative stress | associated_with | process | 0.85 |
| endothelial cell dysfunction | causes | phenotype | 0.85 |
| Neurodegeneration | contributes_to | disease | 0.85 |
| Mitophagy dysfunction | contributes_to | process | 0.80 |
| neurovascular coupling | associated_with | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DRP1 | mediates | protein | 0.95 |
| SARS-COV-2 MEMBRANE PROTEIN | causes | protein | 0.95 |
| SARS-CoV-2 M Protein | causes | protein | 0.95 |
| Sars-Cov-2 M Protein | causes | protein | 0.95 |
| Paclitaxel | causes | drug | 0.95 |
| High-dose Palmitic Acid | causes | compound | 0.95 |
| Ocular Hypertension | causes | phenotype | 0.95 |
| DRP1 | activates | gene | 0.95 |
| palmitic acid | causes | drug | 0.94 |
| TRPML1 | prevents | protein | 0.92 |
| PINK1 | inhibits | gene | 0.90 |
| PINK1 | protects_against | gene | 0.90 |
| MFF | mediates | protein | 0.90 |
| Caspase-3-Cleaved Tau | associated_with | protein | 0.90 |
| ocular hypertension | causes | phenotype | 0.90 |
| oxidative stress | causes | phenotype | 0.90 |
| Mapk | causes | pathway | 0.90 |
| Alpha-Synuclein Aggregation | causes | process | 0.89 |
| FIS1 | mediates | gene | 0.85 |
| Golgi-Mitochondria Interaction Disruption | mediates | mechanism | 0.85 |
| DRP1 | mediates | gene | 0.85 |
| Atg7 | regulates | gene | 0.80 |
| LC3 | regulates | gene | 0.80 |
| AMPK | promotes | protein | 0.80 |
| reactive oxygen species | activates | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||